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  • 11.0 [archived version]
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NPIPA3 NPIPA3 NPIPA2 NPIPA2 SUDS3 SUDS3 USP17L30 USP17L30 USP17L27 USP17L27 USP17L28 USP17L28 RCE1 RCE1 USP17L29 USP17L29 IL33 IL33 USP13 USP13 OTUD6B OTUD6B
"USP17L27" - Ubiquitin specific peptidase 17-like family member 27 in Homo sapiens
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query proteins and first shell of interactors
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second shell of interactors
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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USP17L27Ubiquitin specific peptidase 17-like family member 27; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection; Belongs to the peptidase C19 family. USP17 subfamily (530 aa)    
Predicted Functional Partners:
USP17L28
Ubiquitin specific peptidase 17-like family member 28; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection (530 aa)
     
     
0.771
USP17L29
Ubiquitin specific peptidase 17-like family member 29; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection (530 aa)
     
     
0.771
USP17L30
Ubiquitin specific peptidase 17-like family member 30; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection (530 aa)
     
     
0.771
RCE1
CAAX prenyl protease 2; Proteolytically removes the C-terminal three residues of farnesylated and geranylated proteins. Seems to be able to process K-Ras, N-Ras, H-Ras, RAP1B and G-gamma-1 (329 aa)
           
  0.672
OTUD6B
OTU domain containing 6B (323 aa)
           
  0.564
NPIPA3
Nuclear pore complex interacting protein family member A3; Belongs to the NPIP family (350 aa)
           
  0.540
SUDS3
Sin3 histone deacetylase corepressor complex component SDS3; Regulatory protein which represses transcription and augments histone deacetylase activity of HDAC1. May have a potential role in tumor suppressor pathways through regulation of apoptosis. May function in the assembly and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes (328 aa)
           
  0.533
USP13
Ubiquitin carboxyl-terminal hydrolase 13; Deubiquitinase that mediates deubiquitination of target proteins such as BECN1, MITF, SKP2 and USP10 and is involved in various processes such as autophagy and endoplasmic reticulum- associated degradation (ERAD). Component of a regulatory loop that controls autophagy and p53/TP53 levels- mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes. Also deubiquitinates USP10, an essential regulator of p53/TP53 stability. In turn, PIK3C3/VPS34- containing complexes regulate USP13 s [...] (863 aa)
     
   
  0.523
NPIPA2
Nuclear pore complex interacting protein family member A2 (350 aa)
           
  0.491
IL33
Interleukin-33; Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells. Involved in the maturation of Th2 cells inducing the secretion of T-helper type 2-associated cytokines. Also involved in activation of mast cells, basophils, eosinophils and natural killer cells. Acts as a chemoattractant for Th2 cells, and may function as an "alarmin", that amplifies immune responses during tissue injury; Interleukins (270 aa)
           
  0.487
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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