node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
IL33 | USP17L27 | ENSP00000370842 | ENSP00000423211 | Interleukin-33; Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells. Involved in the maturation of Th2 cells inducing the secretion of T-helper type 2-associated cytokines. Also involved in activation of mast cells, basophils, eosinophils and natural killer cells. Acts as a chemoattractant for Th2 cells, and may function as an "alarmin", that amplifies immune responses during tissue injury; Interleukins | Ubiquitin specific peptidase 17-like family member 27; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection; Belongs to the peptidase C19 family. USP17 subfamily | 0.487 |
IL33 | USP17L28 | ENSP00000370842 | ENSP00000423777 | Interleukin-33; Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells. Involved in the maturation of Th2 cells inducing the secretion of T-helper type 2-associated cytokines. Also involved in activation of mast cells, basophils, eosinophils and natural killer cells. Acts as a chemoattractant for Th2 cells, and may function as an "alarmin", that amplifies immune responses during tissue injury; Interleukins | Ubiquitin specific peptidase 17-like family member 28; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection | 0.487 |
IL33 | USP17L29 | ENSP00000370842 | ENSP00000422969 | Interleukin-33; Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells. Involved in the maturation of Th2 cells inducing the secretion of T-helper type 2-associated cytokines. Also involved in activation of mast cells, basophils, eosinophils and natural killer cells. Acts as a chemoattractant for Th2 cells, and may function as an "alarmin", that amplifies immune responses during tissue injury; Interleukins | Ubiquitin specific peptidase 17-like family member 29; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection | 0.487 |
IL33 | USP17L30 | ENSP00000370842 | ENSP00000422887 | Interleukin-33; Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells. Involved in the maturation of Th2 cells inducing the secretion of T-helper type 2-associated cytokines. Also involved in activation of mast cells, basophils, eosinophils and natural killer cells. Acts as a chemoattractant for Th2 cells, and may function as an "alarmin", that amplifies immune responses during tissue injury; Interleukins | Ubiquitin specific peptidase 17-like family member 30; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection | 0.487 |
NPIPA2 | USP17L27 | ENSP00000446882 | ENSP00000423211 | Nuclear pore complex interacting protein family member A2 | Ubiquitin specific peptidase 17-like family member 27; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection; Belongs to the peptidase C19 family. USP17 subfamily | 0.491 |
NPIPA2 | USP17L28 | ENSP00000446882 | ENSP00000423777 | Nuclear pore complex interacting protein family member A2 | Ubiquitin specific peptidase 17-like family member 28; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection | 0.491 |
NPIPA2 | USP17L29 | ENSP00000446882 | ENSP00000422969 | Nuclear pore complex interacting protein family member A2 | Ubiquitin specific peptidase 17-like family member 29; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection | 0.491 |
NPIPA2 | USP17L30 | ENSP00000446882 | ENSP00000422887 | Nuclear pore complex interacting protein family member A2 | Ubiquitin specific peptidase 17-like family member 30; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection | 0.491 |
NPIPA3 | USP17L27 | ENSP00000448841 | ENSP00000423211 | Nuclear pore complex interacting protein family member A3; Belongs to the NPIP family | Ubiquitin specific peptidase 17-like family member 27; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection; Belongs to the peptidase C19 family. USP17 subfamily | 0.540 |
NPIPA3 | USP17L28 | ENSP00000448841 | ENSP00000423777 | Nuclear pore complex interacting protein family member A3; Belongs to the NPIP family | Ubiquitin specific peptidase 17-like family member 28; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection | 0.541 |
NPIPA3 | USP17L29 | ENSP00000448841 | ENSP00000422969 | Nuclear pore complex interacting protein family member A3; Belongs to the NPIP family | Ubiquitin specific peptidase 17-like family member 29; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection | 0.541 |
NPIPA3 | USP17L30 | ENSP00000448841 | ENSP00000422887 | Nuclear pore complex interacting protein family member A3; Belongs to the NPIP family | Ubiquitin specific peptidase 17-like family member 30; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection | 0.541 |
OTUD6B | USP13 | ENSP00000285420 | ENSP00000263966 | OTU domain containing 6B | Ubiquitin carboxyl-terminal hydrolase 13; Deubiquitinase that mediates deubiquitination of target proteins such as BECN1, MITF, SKP2 and USP10 and is involved in various processes such as autophagy and endoplasmic reticulum- associated degradation (ERAD). Component of a regulatory loop that controls autophagy and p53/TP53 levels- mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes. Also deubiquitinates USP10, an essential regulator of p53/TP53 stability. In turn, PIK3C3/VPS34- containing complexes regulate USP13 s [...] | 0.604 |
OTUD6B | USP17L27 | ENSP00000285420 | ENSP00000423211 | OTU domain containing 6B | Ubiquitin specific peptidase 17-like family member 27; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection; Belongs to the peptidase C19 family. USP17 subfamily | 0.564 |
OTUD6B | USP17L28 | ENSP00000285420 | ENSP00000423777 | OTU domain containing 6B | Ubiquitin specific peptidase 17-like family member 28; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection | 0.565 |
OTUD6B | USP17L29 | ENSP00000285420 | ENSP00000422969 | OTU domain containing 6B | Ubiquitin specific peptidase 17-like family member 29; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection | 0.565 |
OTUD6B | USP17L30 | ENSP00000285420 | ENSP00000422887 | OTU domain containing 6B | Ubiquitin specific peptidase 17-like family member 30; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection | 0.565 |
RCE1 | SUDS3 | ENSP00000309163 | ENSP00000443988 | CAAX prenyl protease 2; Proteolytically removes the C-terminal three residues of farnesylated and geranylated proteins. Seems to be able to process K-Ras, N-Ras, H-Ras, RAP1B and G-gamma-1 | Sin3 histone deacetylase corepressor complex component SDS3; Regulatory protein which represses transcription and augments histone deacetylase activity of HDAC1. May have a potential role in tumor suppressor pathways through regulation of apoptosis. May function in the assembly and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes | 0.440 |
RCE1 | USP17L27 | ENSP00000309163 | ENSP00000423211 | CAAX prenyl protease 2; Proteolytically removes the C-terminal three residues of farnesylated and geranylated proteins. Seems to be able to process K-Ras, N-Ras, H-Ras, RAP1B and G-gamma-1 | Ubiquitin specific peptidase 17-like family member 27; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection; Belongs to the peptidase C19 family. USP17 subfamily | 0.672 |
RCE1 | USP17L28 | ENSP00000309163 | ENSP00000423777 | CAAX prenyl protease 2; Proteolytically removes the C-terminal three residues of farnesylated and geranylated proteins. Seems to be able to process K-Ras, N-Ras, H-Ras, RAP1B and G-gamma-1 | Ubiquitin specific peptidase 17-like family member 28; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection | 0.672 |