TRIML2 protein (human) - STRING database

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TRIML2

Probable E3 ubiquitin-protein ligase TRIML2; Tripartite motif family like 2 (387 aa)

Predicted Functional Partners:

TRIM52

0.765

CMYA5

0.712

KXD1

0.625

ENSG00000273748

0.609

TRIM2

0.608

FRG1

0.599

FAM149A

0.509

ZFP42

0.502

CCDC110

0.471

HECW1

0.470

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CCDC110	FAM149A	ENSP00000306776	ENSP00000227065	Coiled-coil domain containing 110	Protein FAM149A; Family with sequence similarity 149 member A	0.527
CCDC110	TRIML2	ENSP00000306776	ENSP00000422581	Coiled-coil domain containing 110	Probable E3 ubiquitin-protein ligase TRIML2; Tripartite motif family like 2	0.471
CMYA5	TRIM2	ENSP00000394770	ENSP00000339659	Cardiomyopathy-associated protein 5; May serve as an anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) via binding to PRKAR2A (By similarity). May function as a repressor of calcineurin-mediated transcriptional activity. May attenuate calcineurin ability to induce slow-fiber gene program in muscle and may negatively modulate skeletal muscle regeneration (By similarity); A-kinase anchoring proteins	Tripartite motif-containing protein 2; UBE2D1-dependent E3 ubiquitin-protein ligase that mediates the ubiquitination of NEFL and of phosphorylated BCL2L11. Plays a neuroprotective function. May play a role in neuronal rapid ischemic tolerance; Belongs to the TRIM/RBCC family	0.536
CMYA5	TRIM52	ENSP00000394770	ENSP00000483005	Cardiomyopathy-associated protein 5; May serve as an anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) via binding to PRKAR2A (By similarity). May function as a repressor of calcineurin-mediated transcriptional activity. May attenuate calcineurin ability to induce slow-fiber gene program in muscle and may negatively modulate skeletal muscle regeneration (By similarity); A-kinase anchoring proteins	Tripartite motif containing 52; Ring finger proteins	0.649
CMYA5	TRIML2	ENSP00000394770	ENSP00000422581	Cardiomyopathy-associated protein 5; May serve as an anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) via binding to PRKAR2A (By similarity). May function as a repressor of calcineurin-mediated transcriptional activity. May attenuate calcineurin ability to induce slow-fiber gene program in muscle and may negatively modulate skeletal muscle regeneration (By similarity); A-kinase anchoring proteins	Probable E3 ubiquitin-protein ligase TRIML2; Tripartite motif family like 2	0.712
ENSG00000273748	FAM149A	ENSP00000479921	ENSP00000227065	annotation not available	Protein FAM149A; Family with sequence similarity 149 member A	0.511
ENSG00000273748	TRIML2	ENSP00000479921	ENSP00000422581	annotation not available	Probable E3 ubiquitin-protein ligase TRIML2; Tripartite motif family like 2	0.609
FAM149A	CCDC110	ENSP00000227065	ENSP00000306776	Protein FAM149A; Family with sequence similarity 149 member A	Coiled-coil domain containing 110	0.527
FAM149A	ENSG00000273748	ENSP00000227065	ENSP00000479921	Protein FAM149A; Family with sequence similarity 149 member A	annotation not available	0.511
FAM149A	FRG1	ENSP00000227065	ENSP00000226798	Protein FAM149A; Family with sequence similarity 149 member A	Protein FRG1; Binds to mRNA in a sequence-independent manner. May play a role in regulation of pre-mRNA splicing or in the assembly of rRNA into ribosomal subunits. May be involved in mRNA transport. May be involved in epigenetic regulation of muscle differentiation through regulation of activity of the histone-lysine N- methyltransferase KMT5B; Belongs to the FRG1 family	0.491
FAM149A	TRIML2	ENSP00000227065	ENSP00000422581	Protein FAM149A; Family with sequence similarity 149 member A	Probable E3 ubiquitin-protein ligase TRIML2; Tripartite motif family like 2	0.509
FRG1	FAM149A	ENSP00000226798	ENSP00000227065	Protein FRG1; Binds to mRNA in a sequence-independent manner. May play a role in regulation of pre-mRNA splicing or in the assembly of rRNA into ribosomal subunits. May be involved in mRNA transport. May be involved in epigenetic regulation of muscle differentiation through regulation of activity of the histone-lysine N- methyltransferase KMT5B; Belongs to the FRG1 family	Protein FAM149A; Family with sequence similarity 149 member A	0.491
FRG1	TRIML2	ENSP00000226798	ENSP00000422581	Protein FRG1; Binds to mRNA in a sequence-independent manner. May play a role in regulation of pre-mRNA splicing or in the assembly of rRNA into ribosomal subunits. May be involved in mRNA transport. May be involved in epigenetic regulation of muscle differentiation through regulation of activity of the histone-lysine N- methyltransferase KMT5B; Belongs to the FRG1 family	Probable E3 ubiquitin-protein ligase TRIML2; Tripartite motif family like 2	0.599
HECW1	TRIML2	ENSP00000379228	ENSP00000422581	E3 ubiquitin-protein ligase HECW1; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent degradation of DVL1. Also targets the mutant SOD1 protein involved in familial amyotrophic lateral sclerosis (FALS). Forms cytotoxic aggregates with DVL1, SSR3 and mutant SOD1 that lead to motor neuron death in FALS; C2 domain containing	Probable E3 ubiquitin-protein ligase TRIML2; Tripartite motif family like 2	0.470
KXD1	TRIML2	ENSP00000472836	ENSP00000422581	KxDL motif-containing protein 1; As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor. May be involved in the biogenesis of lysosome-related organelles such as melanosomes (By similarity); Belongs to the KXD1 family	Probable E3 ubiquitin-protein ligase TRIML2; Tripartite motif family like 2	0.625
TRIM2	CMYA5	ENSP00000339659	ENSP00000394770	Tripartite motif-containing protein 2; UBE2D1-dependent E3 ubiquitin-protein ligase that mediates the ubiquitination of NEFL and of phosphorylated BCL2L11. Plays a neuroprotective function. May play a role in neuronal rapid ischemic tolerance; Belongs to the TRIM/RBCC family	Cardiomyopathy-associated protein 5; May serve as an anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) via binding to PRKAR2A (By similarity). May function as a repressor of calcineurin-mediated transcriptional activity. May attenuate calcineurin ability to induce slow-fiber gene program in muscle and may negatively modulate skeletal muscle regeneration (By similarity); A-kinase anchoring proteins	0.536
TRIM2	TRIM52	ENSP00000339659	ENSP00000483005	Tripartite motif-containing protein 2; UBE2D1-dependent E3 ubiquitin-protein ligase that mediates the ubiquitination of NEFL and of phosphorylated BCL2L11. Plays a neuroprotective function. May play a role in neuronal rapid ischemic tolerance; Belongs to the TRIM/RBCC family	Tripartite motif containing 52; Ring finger proteins	0.528
TRIM2	TRIML2	ENSP00000339659	ENSP00000422581	Tripartite motif-containing protein 2; UBE2D1-dependent E3 ubiquitin-protein ligase that mediates the ubiquitination of NEFL and of phosphorylated BCL2L11. Plays a neuroprotective function. May play a role in neuronal rapid ischemic tolerance; Belongs to the TRIM/RBCC family	Probable E3 ubiquitin-protein ligase TRIML2; Tripartite motif family like 2	0.608
TRIM52	CMYA5	ENSP00000483005	ENSP00000394770	Tripartite motif containing 52; Ring finger proteins	Cardiomyopathy-associated protein 5; May serve as an anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) via binding to PRKAR2A (By similarity). May function as a repressor of calcineurin-mediated transcriptional activity. May attenuate calcineurin ability to induce slow-fiber gene program in muscle and may negatively modulate skeletal muscle regeneration (By similarity); A-kinase anchoring proteins	0.649
TRIM52	TRIM2	ENSP00000483005	ENSP00000339659	Tripartite motif containing 52; Ring finger proteins	Tripartite motif-containing protein 2; UBE2D1-dependent E3 ubiquitin-protein ligase that mediates the ubiquitination of NEFL and of phosphorylated BCL2L11. Plays a neuroprotective function. May play a role in neuronal rapid ischemic tolerance; Belongs to the TRIM/RBCC family	0.528

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