| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ADAM19 | C10orf11 | ENSP00000257527 | ENSP00000361577 | Disintegrin and metalloproteinase domain-containing protein 19; Participates in the proteolytic processing of beta-type neuregulin isoforms which are involved in neurogenesis and synaptogenesis, suggesting a regulatory role in glial cell. Also cleaves alpha-2 macroglobulin. May be involved in osteoblast differentiation and/or osteoblast activity in bone (By similarity); ADAM metallopeptidase domain containing | Leucine-rich melanocyte differentiation-associated protein; Required for melanocyte differentiation | 0.414 |
| ADAM19 | FAM13A | ENSP00000257527 | ENSP00000264344 | Disintegrin and metalloproteinase domain-containing protein 19; Participates in the proteolytic processing of beta-type neuregulin isoforms which are involved in neurogenesis and synaptogenesis, suggesting a regulatory role in glial cell. Also cleaves alpha-2 macroglobulin. May be involved in osteoblast differentiation and/or osteoblast activity in bone (By similarity); ADAM metallopeptidase domain containing | Protein FAM13A; Family with sequence similarity 13 member A; Belongs to the FAM13 family | 0.564 |
| ADAM19 | GPR126 | ENSP00000257527 | ENSP00000356581 | Disintegrin and metalloproteinase domain-containing protein 19; Participates in the proteolytic processing of beta-type neuregulin isoforms which are involved in neurogenesis and synaptogenesis, suggesting a regulatory role in glial cell. Also cleaves alpha-2 macroglobulin. May be involved in osteoblast differentiation and/or osteoblast activity in bone (By similarity); ADAM metallopeptidase domain containing | Adhesion G-protein coupled receptor G6; G-protein coupled receptor which is activated by type IV collagen, a major constituent of the basement membrane (By similarity). Couples to G(i)-proteins as well as G(s)-proteins. Essential for normal differentiation of promyelinating Schwann cells and for normal myelination of axons. Regulates neural, cardiac and ear development via G-protein- and/or N-terminus-dependent signaling (By similarity). May act as a receptor for PRNP which may promote myelin homeostasis (By similarity) | 0.438 |
| ADAM19 | GSTCD | ENSP00000257527 | ENSP00000422354 | Disintegrin and metalloproteinase domain-containing protein 19; Participates in the proteolytic processing of beta-type neuregulin isoforms which are involved in neurogenesis and synaptogenesis, suggesting a regulatory role in glial cell. Also cleaves alpha-2 macroglobulin. May be involved in osteoblast differentiation and/or osteoblast activity in bone (By similarity); ADAM metallopeptidase domain containing | Glutathione S-transferase C-terminal domain containing; Belongs to the GSTCD family | 0.654 |
| ADAM19 | HHIP | ENSP00000257527 | ENSP00000296575 | Disintegrin and metalloproteinase domain-containing protein 19; Participates in the proteolytic processing of beta-type neuregulin isoforms which are involved in neurogenesis and synaptogenesis, suggesting a regulatory role in glial cell. Also cleaves alpha-2 macroglobulin. May be involved in osteoblast differentiation and/or osteoblast activity in bone (By similarity); ADAM metallopeptidase domain containing | Hedgehog-interacting protein; Modulates hedgehog signaling in several cell types including brain and lung through direct interaction with members of the hedgehog family | 0.511 |
| ADAM19 | INTS12 | ENSP00000257527 | ENSP00000415433 | Disintegrin and metalloproteinase domain-containing protein 19; Participates in the proteolytic processing of beta-type neuregulin isoforms which are involved in neurogenesis and synaptogenesis, suggesting a regulatory role in glial cell. Also cleaves alpha-2 macroglobulin. May be involved in osteoblast differentiation and/or osteoblast activity in bone (By similarity); ADAM metallopeptidase domain containing | Integrator complex subunit 12; Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3’-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex | 0.541 |
| ADAM19 | NPNT | ENSP00000257527 | ENSP00000389252 | Disintegrin and metalloproteinase domain-containing protein 19; Participates in the proteolytic processing of beta-type neuregulin isoforms which are involved in neurogenesis and synaptogenesis, suggesting a regulatory role in glial cell. Also cleaves alpha-2 macroglobulin. May be involved in osteoblast differentiation and/or osteoblast activity in bone (By similarity); ADAM metallopeptidase domain containing | Nephronectin; Functional ligand of integrin alpha-8/beta-1 in kidney development. Regulates the expression of GDNF with integrin alpha- 8/beta-1 which is essential for kidney development. May also play a role in the development and function of various tissues, regulating cell adhesion, spreading and survival through the binding of several integrins (By similarity) | 0.466 |
| ADAM19 | SPATA9 | ENSP00000257527 | ENSP00000274432 | Disintegrin and metalloproteinase domain-containing protein 19; Participates in the proteolytic processing of beta-type neuregulin isoforms which are involved in neurogenesis and synaptogenesis, suggesting a regulatory role in glial cell. Also cleaves alpha-2 macroglobulin. May be involved in osteoblast differentiation and/or osteoblast activity in bone (By similarity); ADAM metallopeptidase domain containing | Spermatogenesis-associated protein 9; May play a role in testicular development/spermatogenesis and may be an important factor in male infertility | 0.410 |
| ADAM19 | THSD4 | ENSP00000257527 | ENSP00000347484 | Disintegrin and metalloproteinase domain-containing protein 19; Participates in the proteolytic processing of beta-type neuregulin isoforms which are involved in neurogenesis and synaptogenesis, suggesting a regulatory role in glial cell. Also cleaves alpha-2 macroglobulin. May be involved in osteoblast differentiation and/or osteoblast activity in bone (By similarity); ADAM metallopeptidase domain containing | Thrombospondin type-1 domain-containing protein 4; Promotes FBN1 matrix assembly. Attenuates TGFB signaling, possibly by accelerating the sequestration of large latent complexes of TGFB or active TGFB by FBN1 microfibril assembly, thereby negatively regulating the expression of TGFB regulatory targets, such as POSTN (By similarity); ADAMTS like | 0.594 |
| ARHGEF38 | GSTCD | ENSP00000416125 | ENSP00000422354 | Rho guanine nucleotide exchange factor 38; May act as a guanine-nucleotide releasing factor; Classical BAR domain containing | Glutathione S-transferase C-terminal domain containing; Belongs to the GSTCD family | 0.669 |
| ARHGEF38 | INTS12 | ENSP00000416125 | ENSP00000415433 | Rho guanine nucleotide exchange factor 38; May act as a guanine-nucleotide releasing factor; Classical BAR domain containing | Integrator complex subunit 12; Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3’-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex | 0.774 |
| ARHGEF38 | NPNT | ENSP00000416125 | ENSP00000389252 | Rho guanine nucleotide exchange factor 38; May act as a guanine-nucleotide releasing factor; Classical BAR domain containing | Nephronectin; Functional ligand of integrin alpha-8/beta-1 in kidney development. Regulates the expression of GDNF with integrin alpha- 8/beta-1 which is essential for kidney development. May also play a role in the development and function of various tissues, regulating cell adhesion, spreading and survival through the binding of several integrins (By similarity) | 0.689 |
| ARHGEF38 | THSD4 | ENSP00000416125 | ENSP00000347484 | Rho guanine nucleotide exchange factor 38; May act as a guanine-nucleotide releasing factor; Classical BAR domain containing | Thrombospondin type-1 domain-containing protein 4; Promotes FBN1 matrix assembly. Attenuates TGFB signaling, possibly by accelerating the sequestration of large latent complexes of TGFB or active TGFB by FBN1 microfibril assembly, thereby negatively regulating the expression of TGFB regulatory targets, such as POSTN (By similarity); ADAMTS like | 0.468 |
| C10orf11 | ADAM19 | ENSP00000361577 | ENSP00000257527 | Leucine-rich melanocyte differentiation-associated protein; Required for melanocyte differentiation | Disintegrin and metalloproteinase domain-containing protein 19; Participates in the proteolytic processing of beta-type neuregulin isoforms which are involved in neurogenesis and synaptogenesis, suggesting a regulatory role in glial cell. Also cleaves alpha-2 macroglobulin. May be involved in osteoblast differentiation and/or osteoblast activity in bone (By similarity); ADAM metallopeptidase domain containing | 0.414 |
| C10orf11 | FAM13A | ENSP00000361577 | ENSP00000264344 | Leucine-rich melanocyte differentiation-associated protein; Required for melanocyte differentiation | Protein FAM13A; Family with sequence similarity 13 member A; Belongs to the FAM13 family | 0.554 |
| C10orf11 | GPR126 | ENSP00000361577 | ENSP00000356581 | Leucine-rich melanocyte differentiation-associated protein; Required for melanocyte differentiation | Adhesion G-protein coupled receptor G6; G-protein coupled receptor which is activated by type IV collagen, a major constituent of the basement membrane (By similarity). Couples to G(i)-proteins as well as G(s)-proteins. Essential for normal differentiation of promyelinating Schwann cells and for normal myelination of axons. Regulates neural, cardiac and ear development via G-protein- and/or N-terminus-dependent signaling (By similarity). May act as a receptor for PRNP which may promote myelin homeostasis (By similarity) | 0.442 |
| C10orf11 | GSTCD | ENSP00000361577 | ENSP00000422354 | Leucine-rich melanocyte differentiation-associated protein; Required for melanocyte differentiation | Glutathione S-transferase C-terminal domain containing; Belongs to the GSTCD family | 0.588 |
| C10orf11 | HHIP | ENSP00000361577 | ENSP00000296575 | Leucine-rich melanocyte differentiation-associated protein; Required for melanocyte differentiation | Hedgehog-interacting protein; Modulates hedgehog signaling in several cell types including brain and lung through direct interaction with members of the hedgehog family | 0.479 |
| C10orf11 | SPATA9 | ENSP00000361577 | ENSP00000274432 | Leucine-rich melanocyte differentiation-associated protein; Required for melanocyte differentiation | Spermatogenesis-associated protein 9; May play a role in testicular development/spermatogenesis and may be an important factor in male infertility | 0.651 |
| C10orf11 | THSD4 | ENSP00000361577 | ENSP00000347484 | Leucine-rich melanocyte differentiation-associated protein; Required for melanocyte differentiation | Thrombospondin type-1 domain-containing protein 4; Promotes FBN1 matrix assembly. Attenuates TGFB signaling, possibly by accelerating the sequestration of large latent complexes of TGFB or active TGFB by FBN1 microfibril assembly, thereby negatively regulating the expression of TGFB regulatory targets, such as POSTN (By similarity); ADAMTS like | 0.588 |
