node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
COX20 | NUDT5 | ENSP00000406327 | ENSP00000419628 | Cytochrome c oxidase protein 20 homolog; Mitochondrial respiratory chain complex assembly factors; Belongs to the COX20 family | ADP-sugar pyrophosphatase; Enzyme that can either act as an ADP-sugar pyrophosphatase in absence of diphosphate or catalyze the synthesis of ATP in presence of diphosphate. In absence of diphosphate, hydrolyzes with similar activities various modified nucleoside diphosphates such as ADP-ribose, ADP-mannose, ADP-glucose, 8-oxo-GDP and 8-oxo-dGDP. Can also hydrolyze other nucleotide sugars with low activity. In presence of diphosphate, mediates the synthesis of ATP in the nucleus by catalyzing the conversion of ADP-ribose to ATP and ribose 5- phosphate. Nuclear ATP synthesis takes place [...] | 0.496 |
COX20 | PRRC1 | ENSP00000406327 | ENSP00000421965 | Cytochrome c oxidase protein 20 homolog; Mitochondrial respiratory chain complex assembly factors; Belongs to the COX20 family | Protein PRRC1; Proline rich coiled-coil 1; Belongs to the PRRC1 family | 0.595 |
FBXL17 | PRRC1 | ENSP00000437464 | ENSP00000421965 | F-box/LRR-repeat protein 17; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex; F-box and leucine rich repeat proteins | Protein PRRC1; Proline rich coiled-coil 1; Belongs to the PRRC1 family | 0.525 |
KIAA1024L | PRRC1 | ENSP00000454268 | ENSP00000421965 | UPF0258 protein KIAA1024-like; KIAA1024 like | Protein PRRC1; Proline rich coiled-coil 1; Belongs to the PRRC1 family | 0.649 |
KIAA1024L | TEX43 | ENSP00000454268 | ENSP00000349669 | UPF0258 protein KIAA1024-like; KIAA1024 like | Testis-expressed protein 43; Testis expressed 43 | 0.701 |
NUDT5 | COX20 | ENSP00000419628 | ENSP00000406327 | ADP-sugar pyrophosphatase; Enzyme that can either act as an ADP-sugar pyrophosphatase in absence of diphosphate or catalyze the synthesis of ATP in presence of diphosphate. In absence of diphosphate, hydrolyzes with similar activities various modified nucleoside diphosphates such as ADP-ribose, ADP-mannose, ADP-glucose, 8-oxo-GDP and 8-oxo-dGDP. Can also hydrolyze other nucleotide sugars with low activity. In presence of diphosphate, mediates the synthesis of ATP in the nucleus by catalyzing the conversion of ADP-ribose to ATP and ribose 5- phosphate. Nuclear ATP synthesis takes place [...] | Cytochrome c oxidase protein 20 homolog; Mitochondrial respiratory chain complex assembly factors; Belongs to the COX20 family | 0.496 |
NUDT5 | PRRC1 | ENSP00000419628 | ENSP00000421965 | ADP-sugar pyrophosphatase; Enzyme that can either act as an ADP-sugar pyrophosphatase in absence of diphosphate or catalyze the synthesis of ATP in presence of diphosphate. In absence of diphosphate, hydrolyzes with similar activities various modified nucleoside diphosphates such as ADP-ribose, ADP-mannose, ADP-glucose, 8-oxo-GDP and 8-oxo-dGDP. Can also hydrolyze other nucleotide sugars with low activity. In presence of diphosphate, mediates the synthesis of ATP in the nucleus by catalyzing the conversion of ADP-ribose to ATP and ribose 5- phosphate. Nuclear ATP synthesis takes place [...] | Protein PRRC1; Proline rich coiled-coil 1; Belongs to the PRRC1 family | 0.717 |
PAFAH1B2 | PRRC1 | ENSP00000435289 | ENSP00000421965 | Platelet-activating factor acetylhydrolase IB subunit beta; Inactivates PAF by removing the acetyl group at the sn-2 position. This is a catalytic subunit | Protein PRRC1; Proline rich coiled-coil 1; Belongs to the PRRC1 family | 0.869 |
PAFAH1B2 | PSMG1 | ENSP00000435289 | ENSP00000329915 | Platelet-activating factor acetylhydrolase IB subunit beta; Inactivates PAF by removing the acetyl group at the sn-2 position. This is a catalytic subunit | Proteasome assembly chaperone 1; Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG2. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization | 0.852 |
PAFAH1B2 | RHOA | ENSP00000435289 | ENSP00000400175 | Platelet-activating factor acetylhydrolase IB subunit beta; Inactivates PAF by removing the acetyl group at the sn-2 position. This is a catalytic subunit | Transforming protein RhoA; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Stimulates PKN2 kinase activity. May be an activator of PLCE1. Activated by ARHGEF2, which promotes the exchange of GDP for GTP. Essential for the SPATA13-mediated r [...] | 0.828 |
PAFAH1B2 | SHMT2 | ENSP00000435289 | ENSP00000333667 | Platelet-activating factor acetylhydrolase IB subunit beta; Inactivates PAF by removing the acetyl group at the sn-2 position. This is a catalytic subunit | Serine hydroxymethyltransferase, mitochondrial; Contributes to the de novo mitochondrial thymidylate biosynthesis pathway via its role in glycine and tetrahydrofolate metabolism. Thymidylate biosynthesis is required to prevent uracil accumulation in mtDNA. Interconversion of serine and glycine. Associates with mitochondrial DNA. Plays a role in the deubiquitination of target proteins as component of the BRISC complex. Required for IFNAR1 deubiquitination by the BRISC complex; Belongs to the SHMT family | 0.410 |
PRRC1 | COX20 | ENSP00000421965 | ENSP00000406327 | Protein PRRC1; Proline rich coiled-coil 1; Belongs to the PRRC1 family | Cytochrome c oxidase protein 20 homolog; Mitochondrial respiratory chain complex assembly factors; Belongs to the COX20 family | 0.595 |
PRRC1 | FBXL17 | ENSP00000421965 | ENSP00000437464 | Protein PRRC1; Proline rich coiled-coil 1; Belongs to the PRRC1 family | F-box/LRR-repeat protein 17; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex; F-box and leucine rich repeat proteins | 0.525 |
PRRC1 | KIAA1024L | ENSP00000421965 | ENSP00000454268 | Protein PRRC1; Proline rich coiled-coil 1; Belongs to the PRRC1 family | UPF0258 protein KIAA1024-like; KIAA1024 like | 0.649 |
PRRC1 | NUDT5 | ENSP00000421965 | ENSP00000419628 | Protein PRRC1; Proline rich coiled-coil 1; Belongs to the PRRC1 family | ADP-sugar pyrophosphatase; Enzyme that can either act as an ADP-sugar pyrophosphatase in absence of diphosphate or catalyze the synthesis of ATP in presence of diphosphate. In absence of diphosphate, hydrolyzes with similar activities various modified nucleoside diphosphates such as ADP-ribose, ADP-mannose, ADP-glucose, 8-oxo-GDP and 8-oxo-dGDP. Can also hydrolyze other nucleotide sugars with low activity. In presence of diphosphate, mediates the synthesis of ATP in the nucleus by catalyzing the conversion of ADP-ribose to ATP and ribose 5- phosphate. Nuclear ATP synthesis takes place [...] | 0.717 |
PRRC1 | PAFAH1B2 | ENSP00000421965 | ENSP00000435289 | Protein PRRC1; Proline rich coiled-coil 1; Belongs to the PRRC1 family | Platelet-activating factor acetylhydrolase IB subunit beta; Inactivates PAF by removing the acetyl group at the sn-2 position. This is a catalytic subunit | 0.869 |
PRRC1 | PSMG1 | ENSP00000421965 | ENSP00000329915 | Protein PRRC1; Proline rich coiled-coil 1; Belongs to the PRRC1 family | Proteasome assembly chaperone 1; Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG2. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization | 0.866 |
PRRC1 | RHOA | ENSP00000421965 | ENSP00000400175 | Protein PRRC1; Proline rich coiled-coil 1; Belongs to the PRRC1 family | Transforming protein RhoA; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Stimulates PKN2 kinase activity. May be an activator of PLCE1. Activated by ARHGEF2, which promotes the exchange of GDP for GTP. Essential for the SPATA13-mediated r [...] | 0.813 |
PRRC1 | SHMT2 | ENSP00000421965 | ENSP00000333667 | Protein PRRC1; Proline rich coiled-coil 1; Belongs to the PRRC1 family | Serine hydroxymethyltransferase, mitochondrial; Contributes to the de novo mitochondrial thymidylate biosynthesis pathway via its role in glycine and tetrahydrofolate metabolism. Thymidylate biosynthesis is required to prevent uracil accumulation in mtDNA. Interconversion of serine and glycine. Associates with mitochondrial DNA. Plays a role in the deubiquitination of target proteins as component of the BRISC complex. Required for IFNAR1 deubiquitination by the BRISC complex; Belongs to the SHMT family | 0.526 |
PRRC1 | TEX43 | ENSP00000421965 | ENSP00000349669 | Protein PRRC1; Proline rich coiled-coil 1; Belongs to the PRRC1 family | Testis-expressed protein 43; Testis expressed 43 | 0.542 |