| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CATSPER2 | GPR33 | ENSP00000371180 | ENSP00000421557 | Cation channel sperm-associated protein 2; Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte; Belongs to the cation channel sperm-associated (TC 1.A.1.19) family | Probable G-protein coupled receptor 33; Orphan receptor; could be a chemoattractant receptor; Belongs to the G-protein coupled receptor 1 family | 0.429 |
| EBPL | GPR33 | ENSP00000242827 | ENSP00000421557 | Emopamil-binding protein-like; Does not possess sterol isomerase activity and does not bind sigma ligands | Probable G-protein coupled receptor 33; Orphan receptor; could be a chemoattractant receptor; Belongs to the G-protein coupled receptor 1 family | 0.442 |
| EBPL | ZNF512 | ENSP00000242827 | ENSP00000347648 | Emopamil-binding protein-like; Does not possess sterol isomerase activity and does not bind sigma ligands | Zinc finger protein 512; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.448 |
| EEF1D | GPR33 | ENSP00000410059 | ENSP00000421557 | Elongation factor 1-delta; Isoform 1- EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP, regenerating EF-1- alpha for another round of transfer of aminoacyl-tRNAs to the ribosome; Belongs to the EF-1-beta/EF-1-delta family | Probable G-protein coupled receptor 33; Orphan receptor; could be a chemoattractant receptor; Belongs to the G-protein coupled receptor 1 family | 0.435 |
| EEF1D | OR4N5 | ENSP00000410059 | ENSP00000332110 | Elongation factor 1-delta; Isoform 1- EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP, regenerating EF-1- alpha for another round of transfer of aminoacyl-tRNAs to the ribosome; Belongs to the EF-1-beta/EF-1-delta family | Olfactory receptor 4N5; Odorant receptor; Olfactory receptors, family 4 | 0.526 |
| GPR157 | GPR33 | ENSP00000366628 | ENSP00000421557 | G-protein coupled receptor 157; Orphan receptor that promotes neuronal differentiation of radial glial progenitors (RGPs). The activity of this receptor is mediated by a G(q)-protein that activates a phosphatidylinositol-calcium second messenger; 7TM orphan receptors | Probable G-protein coupled receptor 33; Orphan receptor; could be a chemoattractant receptor; Belongs to the G-protein coupled receptor 1 family | 0.420 |
| GPR33 | CATSPER2 | ENSP00000421557 | ENSP00000371180 | Probable G-protein coupled receptor 33; Orphan receptor; could be a chemoattractant receptor; Belongs to the G-protein coupled receptor 1 family | Cation channel sperm-associated protein 2; Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte; Belongs to the cation channel sperm-associated (TC 1.A.1.19) family | 0.429 |
| GPR33 | EBPL | ENSP00000421557 | ENSP00000242827 | Probable G-protein coupled receptor 33; Orphan receptor; could be a chemoattractant receptor; Belongs to the G-protein coupled receptor 1 family | Emopamil-binding protein-like; Does not possess sterol isomerase activity and does not bind sigma ligands | 0.442 |
| GPR33 | EEF1D | ENSP00000421557 | ENSP00000410059 | Probable G-protein coupled receptor 33; Orphan receptor; could be a chemoattractant receptor; Belongs to the G-protein coupled receptor 1 family | Elongation factor 1-delta; Isoform 1- EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP, regenerating EF-1- alpha for another round of transfer of aminoacyl-tRNAs to the ribosome; Belongs to the EF-1-beta/EF-1-delta family | 0.435 |
| GPR33 | GPR157 | ENSP00000421557 | ENSP00000366628 | Probable G-protein coupled receptor 33; Orphan receptor; could be a chemoattractant receptor; Belongs to the G-protein coupled receptor 1 family | G-protein coupled receptor 157; Orphan receptor that promotes neuronal differentiation of radial glial progenitors (RGPs). The activity of this receptor is mediated by a G(q)-protein that activates a phosphatidylinositol-calcium second messenger; 7TM orphan receptors | 0.420 |
| GPR33 | KCNE2 | ENSP00000421557 | ENSP00000290310 | Probable G-protein coupled receptor 33; Orphan receptor; could be a chemoattractant receptor; Belongs to the G-protein coupled receptor 1 family | Potassium voltage-gated channel subfamily E member 2; Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1. Associated with KCNH2/HERG is proposed to form the rapidly activating component of the delayed rectifying potassium current in heart (IKr). May associate with KCNQ2 and/or KCNQ3 and modulate the native M-t [...] | 0.430 |
| GPR33 | NBPF19 | ENSP00000421557 | ENSP00000478752 | Probable G-protein coupled receptor 33; Orphan receptor; could be a chemoattractant receptor; Belongs to the G-protein coupled receptor 1 family | Neuroblastoma breakpoint family, member 14; Belongs to the NBPF family | 0.441 |
| GPR33 | NMRAL1 | ENSP00000421557 | ENSP00000458762 | Probable G-protein coupled receptor 33; Orphan receptor; could be a chemoattractant receptor; Belongs to the G-protein coupled receptor 1 family | NmrA-like family domain-containing protein 1; Redox sensor protein. Undergoes restructuring and subcellular redistribution in response to changes in intracellular NADPH/NADP(+) levels. At low NADPH concentrations the protein is found mainly as a monomer, and binds argininosuccinate synthase (ASS1), the enzyme involved in nitric oxide synthesis. Association with ASS1 impairs its activity and reduces the production of nitric oxide, which subsecuently prevents apoptosis. Under normal NADPH concentrations, the protein is found as a dimer and hides the binding site for ASS1. The homodimer b [...] | 0.426 |
| GPR33 | OR4N5 | ENSP00000421557 | ENSP00000332110 | Probable G-protein coupled receptor 33; Orphan receptor; could be a chemoattractant receptor; Belongs to the G-protein coupled receptor 1 family | Olfactory receptor 4N5; Odorant receptor; Olfactory receptors, family 4 | 0.627 |
| GPR33 | PARP9 | ENSP00000421557 | ENSP00000353512 | Probable G-protein coupled receptor 33; Orphan receptor; could be a chemoattractant receptor; Belongs to the G-protein coupled receptor 1 family | Poly [ADP-ribose] polymerase 9; ADP-ribosyltransferase which, in association with E3 ligase DTX3L, plays a role in DNA damage repair and in immune responses including interferon-mediated antiviral defenses. Within the complex, enhances DTX3L E3 ligase activity which is further enhanced by PARP9 binding to poly(ADP- ribose). In association with DTX3L and in presence of E1 and E2 enzymes, mediates NAD(+)-dependent mono-ADP- ribosylation of ubiquitin which prevents ubiquitin conjugation to substrates such as histones. During DNA repair, PARP1 recruits PARP9/BAL1-DTX3L complex to DNA damag [...] | 0.424 |
| GPR33 | ZNF512 | ENSP00000421557 | ENSP00000347648 | Probable G-protein coupled receptor 33; Orphan receptor; could be a chemoattractant receptor; Belongs to the G-protein coupled receptor 1 family | Zinc finger protein 512; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.439 |
| KCNE2 | GPR33 | ENSP00000290310 | ENSP00000421557 | Potassium voltage-gated channel subfamily E member 2; Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1. Associated with KCNH2/HERG is proposed to form the rapidly activating component of the delayed rectifying potassium current in heart (IKr). May associate with KCNQ2 and/or KCNQ3 and modulate the native M-t [...] | Probable G-protein coupled receptor 33; Orphan receptor; could be a chemoattractant receptor; Belongs to the G-protein coupled receptor 1 family | 0.430 |
| NBPF19 | GPR33 | ENSP00000478752 | ENSP00000421557 | Neuroblastoma breakpoint family, member 14; Belongs to the NBPF family | Probable G-protein coupled receptor 33; Orphan receptor; could be a chemoattractant receptor; Belongs to the G-protein coupled receptor 1 family | 0.441 |
| NMRAL1 | GPR33 | ENSP00000458762 | ENSP00000421557 | NmrA-like family domain-containing protein 1; Redox sensor protein. Undergoes restructuring and subcellular redistribution in response to changes in intracellular NADPH/NADP(+) levels. At low NADPH concentrations the protein is found mainly as a monomer, and binds argininosuccinate synthase (ASS1), the enzyme involved in nitric oxide synthesis. Association with ASS1 impairs its activity and reduces the production of nitric oxide, which subsecuently prevents apoptosis. Under normal NADPH concentrations, the protein is found as a dimer and hides the binding site for ASS1. The homodimer b [...] | Probable G-protein coupled receptor 33; Orphan receptor; could be a chemoattractant receptor; Belongs to the G-protein coupled receptor 1 family | 0.426 |
| NMRAL1 | OR4N5 | ENSP00000458762 | ENSP00000332110 | NmrA-like family domain-containing protein 1; Redox sensor protein. Undergoes restructuring and subcellular redistribution in response to changes in intracellular NADPH/NADP(+) levels. At low NADPH concentrations the protein is found mainly as a monomer, and binds argininosuccinate synthase (ASS1), the enzyme involved in nitric oxide synthesis. Association with ASS1 impairs its activity and reduces the production of nitric oxide, which subsecuently prevents apoptosis. Under normal NADPH concentrations, the protein is found as a dimer and hides the binding site for ASS1. The homodimer b [...] | Olfactory receptor 4N5; Odorant receptor; Olfactory receptors, family 4 | 0.619 |
