node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CDKL2 | STEAP4 | ENSP00000412365 | ENSP00000369419 | Cyclin-dependent kinase-like 2; Cyclin dependent kinase like 2; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily | Metalloreductase STEAP4; Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+) (By similarity). Uses NADP(+) as acceptor (By similarity). Plays a role in systemic metabolic homeostasis, integrating inflammatory and metabolic responses (By similarity). Associated with obesity and insulin- resistance. Involved in inflammatory arthritis, through the regulation of inflammatory cytokines. Inhibits anchorage-independent cell proliferation; STEAP family | 0.633 |
CDKL2 | ZNF154 | ENSP00000412365 | ENSP00000421258 | Cyclin-dependent kinase-like 2; Cyclin dependent kinase like 2; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily | Zinc finger protein 154; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.536 |
FAM150A | FAM78A | ENSP00000351345 | ENSP00000361345 | ALK and LTK ligand 1; Ligand for receptor tyrosine kinase LTK and perhaps receptor tyrosine kinase ALK; activation of ALK is reported conflictingly | Protein FAM78A; Family with sequence similarity 78 member A; Belongs to the FAM78 family | 0.591 |
FAM150A | PCDHAC1 | ENSP00000351345 | ENSP00000253807 | ALK and LTK ligand 1; Ligand for receptor tyrosine kinase LTK and perhaps receptor tyrosine kinase ALK; activation of ALK is reported conflictingly | Protocadherin alpha-C1; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain; Clustered protocadherins | 0.587 |
FAM150A | PRAC1 | ENSP00000351345 | ENSP00000290294 | ALK and LTK ligand 1; Ligand for receptor tyrosine kinase LTK and perhaps receptor tyrosine kinase ALK; activation of ALK is reported conflictingly | PRAC1 small nuclear protein | 0.475 |
FAM150A | RIMS4 | ENSP00000351345 | ENSP00000439287 | ALK and LTK ligand 1; Ligand for receptor tyrosine kinase LTK and perhaps receptor tyrosine kinase ALK; activation of ALK is reported conflictingly | Regulating synaptic membrane exocytosis protein 4; Regulates synaptic membrane exocytosis | 0.557 |
FAM150A | ZNF154 | ENSP00000351345 | ENSP00000421258 | ALK and LTK ligand 1; Ligand for receptor tyrosine kinase LTK and perhaps receptor tyrosine kinase ALK; activation of ALK is reported conflictingly | Zinc finger protein 154; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.511 |
FAM78A | FAM150A | ENSP00000361345 | ENSP00000351345 | Protein FAM78A; Family with sequence similarity 78 member A; Belongs to the FAM78 family | ALK and LTK ligand 1; Ligand for receptor tyrosine kinase LTK and perhaps receptor tyrosine kinase ALK; activation of ALK is reported conflictingly | 0.591 |
FAM78A | PCDHAC1 | ENSP00000361345 | ENSP00000253807 | Protein FAM78A; Family with sequence similarity 78 member A; Belongs to the FAM78 family | Protocadherin alpha-C1; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain; Clustered protocadherins | 0.669 |
FAM78A | PRAC1 | ENSP00000361345 | ENSP00000290294 | Protein FAM78A; Family with sequence similarity 78 member A; Belongs to the FAM78 family | PRAC1 small nuclear protein | 0.557 |
FAM78A | RIMS4 | ENSP00000361345 | ENSP00000439287 | Protein FAM78A; Family with sequence similarity 78 member A; Belongs to the FAM78 family | Regulating synaptic membrane exocytosis protein 4; Regulates synaptic membrane exocytosis | 0.655 |
FAM78A | ZNF154 | ENSP00000361345 | ENSP00000421258 | Protein FAM78A; Family with sequence similarity 78 member A; Belongs to the FAM78 family | Zinc finger protein 154; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.571 |
HTN3 | ZNF154 | ENSP00000432561 | ENSP00000421258 | Histatin-3; Histatins are salivary proteins that are considered to be major precursors of the protective proteinaceous structure on tooth surfaces (enamel pellicle). In addition, histatins exhibit antibacterial and antifungal activities. His3-(20-43)-peptide (histatin-5) is especially effective against C.albicans and C.neoformans, and inhibits Lys-gingipain and Arg-gingipain (rgpB) from P.gingivalis. In addition, His3-(20-43)-peptide is a potent inhibitor of metalloproteinases MMP2 and MMP9 | Zinc finger protein 154; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.652 |
PCDHAC1 | FAM150A | ENSP00000253807 | ENSP00000351345 | Protocadherin alpha-C1; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain; Clustered protocadherins | ALK and LTK ligand 1; Ligand for receptor tyrosine kinase LTK and perhaps receptor tyrosine kinase ALK; activation of ALK is reported conflictingly | 0.587 |
PCDHAC1 | FAM78A | ENSP00000253807 | ENSP00000361345 | Protocadherin alpha-C1; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain; Clustered protocadherins | Protein FAM78A; Family with sequence similarity 78 member A; Belongs to the FAM78 family | 0.669 |
PCDHAC1 | PRAC1 | ENSP00000253807 | ENSP00000290294 | Protocadherin alpha-C1; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain; Clustered protocadherins | PRAC1 small nuclear protein | 0.564 |
PCDHAC1 | RIMS4 | ENSP00000253807 | ENSP00000439287 | Protocadherin alpha-C1; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain; Clustered protocadherins | Regulating synaptic membrane exocytosis protein 4; Regulates synaptic membrane exocytosis | 0.678 |
PCDHAC1 | ZNF154 | ENSP00000253807 | ENSP00000421258 | Protocadherin alpha-C1; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain; Clustered protocadherins | Zinc finger protein 154; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.587 |
POU4F2 | ZNF154 | ENSP00000281321 | ENSP00000421258 | POU domain, class 4, transcription factor 2; DNA-binding transcriptional regulator and coregulator that recognizes and binds to the consensus octamer binding site 5’-AT[A/T]A[T/A]T[A/T]A-3’ in promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. Cooperates with the transcription factor ISL1 to achieve RGC fate specification in the developing retina. Plays also a role in RGC axon formation and guidance by regulating gene expression of specific target genes. Plays a role in TNFSF11- mediated terminal [...] | Zinc finger protein 154; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.511 |
PRAC1 | FAM150A | ENSP00000290294 | ENSP00000351345 | PRAC1 small nuclear protein | ALK and LTK ligand 1; Ligand for receptor tyrosine kinase LTK and perhaps receptor tyrosine kinase ALK; activation of ALK is reported conflictingly | 0.475 |