• Version:
  • 11.0 [archived version]
STRINGSTRING
PLEKHA2 PLEKHA2 SLC30A9 SLC30A9 TMEM235 TMEM235 TMEM204 TMEM204 TMEFF1 TMEFF1 CLDND1 CLDND1 GOLGA7 GOLGA7 CLDN25 CLDN25 ZDHHC5 ZDHHC5 GPR15 GPR15 LRRN3 LRRN3
"CLDND1" - Claudin domain containing 1 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CLDND1Claudin domain containing 1 (253 aa)    
Predicted Functional Partners:
ZDHHC5
Palmitoyltransferase ZDHHC5; Palmitoyl acyltransferase for the G-protein coupled receptor SSTR5. Also palmitoylates FLOT2 (By similarity); Zinc fingers DHHC-type (715 aa)
       
      0.812
GOLGA7
Golgin subfamily A member 7; May be involved in protein transport from Golgi to cell surface. The ZDHHC9-GOLGA7 complex is a palmitoyltransferase specific for HRAS and NRAS (137 aa)
     
      0.784
GPR15
G-protein coupled receptor 15; Probable chemokine receptor. Alternative coreceptor with CD4 for HIV-1 infection; G protein-coupled receptors, Class A orphans (360 aa)
           
  0.667
TMEM235
Transmembrane protein 235; Belongs to the PMP-22/EMP/MP20 family (223 aa)
     
   
  0.603
TMEFF1
Tomoregulin-1; May inhibit NODAL and BMP signaling during neural patterning (By similarity). May be a tumor suppressor in brain cancers (380 aa)
       
      0.546
TMEM204
Transmembrane protein 204; Can influence paracellular permeability. Appears to be involved in cell-cell interactions through adherens (226 aa)
           
  0.536
CLDN25
Putative claudin-25; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity; Claudins (229 aa)
           
  0.512
PLEKHA2
Pleckstrin homology domain-containing family A member 2; Binds specifically to phosphatidylinositol 3,4- diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane (By similarity); Pleckstrin homology domain containing (425 aa)
           
  0.493
SLC30A9
Zinc transporter 9; Acts as a zinc transporter involved in intracellular zinc homeostasis. Functions as a secondary coactivator for nuclear receptors by cooperating with p160 coactivators subtypes. Plays a role in transcriptional activation of Wnt-responsive genes (By similarity); Solute carriers (568 aa)
     
   
  0.463
LRRN3
Leucine-rich repeat neuronal protein 3; Fibronectin type III domain containing (708 aa)
           
  0.446
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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