| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| FXYD4 | SPINK13 | ENSP00000483791 | ENSP00000421048 | FXYD domain containing ion transport regulator 4 | Serine protease inhibitor Kazal-type 13; May be a serine protease inhibitor (By similarity). Essential for sperm maturation and fertility. Inhibits sperm acrosome reaction, protecting sperm from premature reaction (By similarity); Serine peptidase inhibitors, Kazal type | 0.509 |
| NDUFA4L2 | SPINK13 | ENSP00000377411 | ENSP00000421048 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2; NDUFA4, mitochondrial complex associated like 2 | Serine protease inhibitor Kazal-type 13; May be a serine protease inhibitor (By similarity). Essential for sperm maturation and fertility. Inhibits sperm acrosome reaction, protecting sperm from premature reaction (By similarity); Serine peptidase inhibitors, Kazal type | 0.468 |
| OR1E1 | SPATA18 | ENSP00000313384 | ENSP00000295213 | Olfactory receptor 1E1; Odorant receptor; Olfactory receptors, family 1 | Mitochondria-eating protein; Key regulator of mitochondrial quality that mediates the repairing or degradation of unhealthy mitochondria in response to mitochondrial damage. Mediator of mitochondrial protein catabolic process (also named MALM) by mediating the degradation of damaged proteins inside mitochondria by promoting the accumulation in the mitochondrial matrix of hydrolases that are characteristic of the lysosomal lumen. Also involved in mitochondrion degradation of damaged mitochondria by promoting the formation of vacuole-like structures (named MIV), which engulf and degrade [...] | 0.615 |
| OR1E1 | SPINK13 | ENSP00000313384 | ENSP00000421048 | Olfactory receptor 1E1; Odorant receptor; Olfactory receptors, family 1 | Serine protease inhibitor Kazal-type 13; May be a serine protease inhibitor (By similarity). Essential for sperm maturation and fertility. Inhibits sperm acrosome reaction, protecting sperm from premature reaction (By similarity); Serine peptidase inhibitors, Kazal type | 0.530 |
| OR1E1 | UNC45B | ENSP00000313384 | ENSP00000268876 | Olfactory receptor 1E1; Odorant receptor; Olfactory receptors, family 1 | Protein unc-45 homolog B; Acts as a co-chaperone for HSP90 and is required for proper folding of the myosin motor domain. Plays a role in sarcomere formation during muscle cell development. Is necessary for normal early lens development; Armadillo-like helical domain containing | 0.594 |
| PILRA | SPINK13 | ENSP00000198536 | ENSP00000421048 | Paired immunoglobulin-like type 2 receptor alpha; Paired receptors consist of highly related activating and inhibitory receptors and are widely involved in the regulation of the immune system. PILRA is thought to act as a cellular signaling inhibitory receptor by recruiting cytoplasmic phosphatases like PTPN6/SHP-1 and PTPN11/SHP-2 via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules. Receptor for PIANP; V-set domain containing | Serine protease inhibitor Kazal-type 13; May be a serine protease inhibitor (By similarity). Essential for sperm maturation and fertility. Inhibits sperm acrosome reaction, protecting sperm from premature reaction (By similarity); Serine peptidase inhibitors, Kazal type | 0.655 |
| SPATA18 | OR1E1 | ENSP00000295213 | ENSP00000313384 | Mitochondria-eating protein; Key regulator of mitochondrial quality that mediates the repairing or degradation of unhealthy mitochondria in response to mitochondrial damage. Mediator of mitochondrial protein catabolic process (also named MALM) by mediating the degradation of damaged proteins inside mitochondria by promoting the accumulation in the mitochondrial matrix of hydrolases that are characteristic of the lysosomal lumen. Also involved in mitochondrion degradation of damaged mitochondria by promoting the formation of vacuole-like structures (named MIV), which engulf and degrade [...] | Olfactory receptor 1E1; Odorant receptor; Olfactory receptors, family 1 | 0.615 |
| SPATA18 | SPINK13 | ENSP00000295213 | ENSP00000421048 | Mitochondria-eating protein; Key regulator of mitochondrial quality that mediates the repairing or degradation of unhealthy mitochondria in response to mitochondrial damage. Mediator of mitochondrial protein catabolic process (also named MALM) by mediating the degradation of damaged proteins inside mitochondria by promoting the accumulation in the mitochondrial matrix of hydrolases that are characteristic of the lysosomal lumen. Also involved in mitochondrion degradation of damaged mitochondria by promoting the formation of vacuole-like structures (named MIV), which engulf and degrade [...] | Serine protease inhibitor Kazal-type 13; May be a serine protease inhibitor (By similarity). Essential for sperm maturation and fertility. Inhibits sperm acrosome reaction, protecting sperm from premature reaction (By similarity); Serine peptidase inhibitors, Kazal type | 0.663 |
| SPATA18 | TGFBI | ENSP00000295213 | ENSP00000416330 | Mitochondria-eating protein; Key regulator of mitochondrial quality that mediates the repairing or degradation of unhealthy mitochondria in response to mitochondrial damage. Mediator of mitochondrial protein catabolic process (also named MALM) by mediating the degradation of damaged proteins inside mitochondria by promoting the accumulation in the mitochondrial matrix of hydrolases that are characteristic of the lysosomal lumen. Also involved in mitochondrion degradation of damaged mitochondria by promoting the formation of vacuole-like structures (named MIV), which engulf and degrade [...] | Transforming growth factor-beta-induced protein ig-h3; Plays a role in cell adhesion. May play a role in cell-collagen interactions (By similarity) | 0.655 |
| SPATA18 | UNC45B | ENSP00000295213 | ENSP00000268876 | Mitochondria-eating protein; Key regulator of mitochondrial quality that mediates the repairing or degradation of unhealthy mitochondria in response to mitochondrial damage. Mediator of mitochondrial protein catabolic process (also named MALM) by mediating the degradation of damaged proteins inside mitochondria by promoting the accumulation in the mitochondrial matrix of hydrolases that are characteristic of the lysosomal lumen. Also involved in mitochondrion degradation of damaged mitochondria by promoting the formation of vacuole-like structures (named MIV), which engulf and degrade [...] | Protein unc-45 homolog B; Acts as a co-chaperone for HSP90 and is required for proper folding of the myosin motor domain. Plays a role in sarcomere formation during muscle cell development. Is necessary for normal early lens development; Armadillo-like helical domain containing | 0.677 |
| SPINK13 | FXYD4 | ENSP00000421048 | ENSP00000483791 | Serine protease inhibitor Kazal-type 13; May be a serine protease inhibitor (By similarity). Essential for sperm maturation and fertility. Inhibits sperm acrosome reaction, protecting sperm from premature reaction (By similarity); Serine peptidase inhibitors, Kazal type | FXYD domain containing ion transport regulator 4 | 0.509 |
| SPINK13 | NDUFA4L2 | ENSP00000421048 | ENSP00000377411 | Serine protease inhibitor Kazal-type 13; May be a serine protease inhibitor (By similarity). Essential for sperm maturation and fertility. Inhibits sperm acrosome reaction, protecting sperm from premature reaction (By similarity); Serine peptidase inhibitors, Kazal type | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2; NDUFA4, mitochondrial complex associated like 2 | 0.468 |
| SPINK13 | OR1E1 | ENSP00000421048 | ENSP00000313384 | Serine protease inhibitor Kazal-type 13; May be a serine protease inhibitor (By similarity). Essential for sperm maturation and fertility. Inhibits sperm acrosome reaction, protecting sperm from premature reaction (By similarity); Serine peptidase inhibitors, Kazal type | Olfactory receptor 1E1; Odorant receptor; Olfactory receptors, family 1 | 0.530 |
| SPINK13 | PILRA | ENSP00000421048 | ENSP00000198536 | Serine protease inhibitor Kazal-type 13; May be a serine protease inhibitor (By similarity). Essential for sperm maturation and fertility. Inhibits sperm acrosome reaction, protecting sperm from premature reaction (By similarity); Serine peptidase inhibitors, Kazal type | Paired immunoglobulin-like type 2 receptor alpha; Paired receptors consist of highly related activating and inhibitory receptors and are widely involved in the regulation of the immune system. PILRA is thought to act as a cellular signaling inhibitory receptor by recruiting cytoplasmic phosphatases like PTPN6/SHP-1 and PTPN11/SHP-2 via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules. Receptor for PIANP; V-set domain containing | 0.655 |
| SPINK13 | SPATA18 | ENSP00000421048 | ENSP00000295213 | Serine protease inhibitor Kazal-type 13; May be a serine protease inhibitor (By similarity). Essential for sperm maturation and fertility. Inhibits sperm acrosome reaction, protecting sperm from premature reaction (By similarity); Serine peptidase inhibitors, Kazal type | Mitochondria-eating protein; Key regulator of mitochondrial quality that mediates the repairing or degradation of unhealthy mitochondria in response to mitochondrial damage. Mediator of mitochondrial protein catabolic process (also named MALM) by mediating the degradation of damaged proteins inside mitochondria by promoting the accumulation in the mitochondrial matrix of hydrolases that are characteristic of the lysosomal lumen. Also involved in mitochondrion degradation of damaged mitochondria by promoting the formation of vacuole-like structures (named MIV), which engulf and degrade [...] | 0.663 |
| SPINK13 | SPINK14 | ENSP00000421048 | ENSP00000349459 | Serine protease inhibitor Kazal-type 13; May be a serine protease inhibitor (By similarity). Essential for sperm maturation and fertility. Inhibits sperm acrosome reaction, protecting sperm from premature reaction (By similarity); Serine peptidase inhibitors, Kazal type | Serine protease inhibitor Kazal-type 14; May be a serine protease inhibitor; Serine peptidase inhibitors, Kazal type | 0.491 |
| SPINK13 | SPINK7 | ENSP00000421048 | ENSP00000274565 | Serine protease inhibitor Kazal-type 13; May be a serine protease inhibitor (By similarity). Essential for sperm maturation and fertility. Inhibits sperm acrosome reaction, protecting sperm from premature reaction (By similarity); Serine peptidase inhibitors, Kazal type | Serine protease inhibitor Kazal-type 7; Probable serine protease inhibitor; Serine peptidase inhibitors, Kazal type | 0.580 |
| SPINK13 | SPINK9 | ENSP00000421048 | ENSP00000367139 | Serine protease inhibitor Kazal-type 13; May be a serine protease inhibitor (By similarity). Essential for sperm maturation and fertility. Inhibits sperm acrosome reaction, protecting sperm from premature reaction (By similarity); Serine peptidase inhibitors, Kazal type | Serine protease inhibitor Kazal-type 9; Serine protease inhibitor which specifically inhibits KLK5. May contribute to the regulation of the desquamation process in skin by inhibiting KLK5; Serine peptidase inhibitors, Kazal type | 0.440 |
| SPINK13 | TGFBI | ENSP00000421048 | ENSP00000416330 | Serine protease inhibitor Kazal-type 13; May be a serine protease inhibitor (By similarity). Essential for sperm maturation and fertility. Inhibits sperm acrosome reaction, protecting sperm from premature reaction (By similarity); Serine peptidase inhibitors, Kazal type | Transforming growth factor-beta-induced protein ig-h3; Plays a role in cell adhesion. May play a role in cell-collagen interactions (By similarity) | 0.459 |
| SPINK13 | UNC45B | ENSP00000421048 | ENSP00000268876 | Serine protease inhibitor Kazal-type 13; May be a serine protease inhibitor (By similarity). Essential for sperm maturation and fertility. Inhibits sperm acrosome reaction, protecting sperm from premature reaction (By similarity); Serine peptidase inhibitors, Kazal type | Protein unc-45 homolog B; Acts as a co-chaperone for HSP90 and is required for proper folding of the myosin motor domain. Plays a role in sarcomere formation during muscle cell development. Is necessary for normal early lens development; Armadillo-like helical domain containing | 0.609 |
