node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADAM30 | CDH22 | ENSP00000358407 | ENSP00000437790 | Disintegrin and metalloproteinase domain-containing protein 30; Plays a role in lysosomal amyloid precursor protein (APP) processing by cleaving and activating CTSD/cathepsin D which leads to APP degradation; ADAM metallopeptidase domain containing | Cadherin-22; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. PB-cadherins may have a role in the morphological organization of pituitary gland and brain tissues (By similarity) | 0.588 |
ADAM30 | DLEU7 | ENSP00000358407 | ENSP00000420976 | Disintegrin and metalloproteinase domain-containing protein 30; Plays a role in lysosomal amyloid precursor protein (APP) processing by cleaving and activating CTSD/cathepsin D which leads to APP degradation; ADAM metallopeptidase domain containing | Leukemia-associated protein 7; Deleted in lymphocytic leukemia, 7 | 0.665 |
ADAM30 | GPR146 | ENSP00000358407 | ENSP00000380283 | Disintegrin and metalloproteinase domain-containing protein 30; Plays a role in lysosomal amyloid precursor protein (APP) processing by cleaving and activating CTSD/cathepsin D which leads to APP degradation; ADAM metallopeptidase domain containing | Probable G-protein coupled receptor 146; Orphan receptor; G protein-coupled receptors, Class A orphans | 0.707 |
ADAM30 | KLHL35 | ENSP00000358407 | ENSP00000438526 | Disintegrin and metalloproteinase domain-containing protein 30; Plays a role in lysosomal amyloid precursor protein (APP) processing by cleaving and activating CTSD/cathepsin D which leads to APP degradation; ADAM metallopeptidase domain containing | Kelch-like protein 35; Kelch like family member 35; BTB domain containing | 0.716 |
CDH22 | ADAM30 | ENSP00000437790 | ENSP00000358407 | Cadherin-22; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. PB-cadherins may have a role in the morphological organization of pituitary gland and brain tissues (By similarity) | Disintegrin and metalloproteinase domain-containing protein 30; Plays a role in lysosomal amyloid precursor protein (APP) processing by cleaving and activating CTSD/cathepsin D which leads to APP degradation; ADAM metallopeptidase domain containing | 0.588 |
CDH22 | DLEU7 | ENSP00000437790 | ENSP00000420976 | Cadherin-22; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. PB-cadherins may have a role in the morphological organization of pituitary gland and brain tissues (By similarity) | Leukemia-associated protein 7; Deleted in lymphocytic leukemia, 7 | 0.624 |
CDH22 | GPR146 | ENSP00000437790 | ENSP00000380283 | Cadherin-22; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. PB-cadherins may have a role in the morphological organization of pituitary gland and brain tissues (By similarity) | Probable G-protein coupled receptor 146; Orphan receptor; G protein-coupled receptors, Class A orphans | 0.665 |
CDH22 | KLHL35 | ENSP00000437790 | ENSP00000438526 | Cadherin-22; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. PB-cadherins may have a role in the morphological organization of pituitary gland and brain tissues (By similarity) | Kelch-like protein 35; Kelch like family member 35; BTB domain containing | 0.700 |
CECR2 | DLEU7 | ENSP00000341219 | ENSP00000420976 | Cat eye syndrome critical region protein 2; Chromatin reader component of histone-modifying complexes, such as the CERF (CECR2-containing-remodeling factor) complex and ISWI-type complex. It thereby plays a role in various processes during development- required during embryogenesis for neural tube closure and inner ear development. In adults, required for spermatogenesis, via the formation of ISWI-type chromatin complexes (By similarity). In histone-modifying complexes, CECR2 recognizes and binds acylated histones- binds histones that are acetylated and/or butyrylated. May also be invo [...] | Leukemia-associated protein 7; Deleted in lymphocytic leukemia, 7 | 0.617 |
DLEU7 | ADAM30 | ENSP00000420976 | ENSP00000358407 | Leukemia-associated protein 7; Deleted in lymphocytic leukemia, 7 | Disintegrin and metalloproteinase domain-containing protein 30; Plays a role in lysosomal amyloid precursor protein (APP) processing by cleaving and activating CTSD/cathepsin D which leads to APP degradation; ADAM metallopeptidase domain containing | 0.665 |
DLEU7 | CDH22 | ENSP00000420976 | ENSP00000437790 | Leukemia-associated protein 7; Deleted in lymphocytic leukemia, 7 | Cadherin-22; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. PB-cadherins may have a role in the morphological organization of pituitary gland and brain tissues (By similarity) | 0.624 |
DLEU7 | CECR2 | ENSP00000420976 | ENSP00000341219 | Leukemia-associated protein 7; Deleted in lymphocytic leukemia, 7 | Cat eye syndrome critical region protein 2; Chromatin reader component of histone-modifying complexes, such as the CERF (CECR2-containing-remodeling factor) complex and ISWI-type complex. It thereby plays a role in various processes during development- required during embryogenesis for neural tube closure and inner ear development. In adults, required for spermatogenesis, via the formation of ISWI-type chromatin complexes (By similarity). In histone-modifying complexes, CECR2 recognizes and binds acylated histones- binds histones that are acetylated and/or butyrylated. May also be invo [...] | 0.617 |
DLEU7 | FAM124A | ENSP00000420976 | ENSP00000280057 | Leukemia-associated protein 7; Deleted in lymphocytic leukemia, 7 | Protein FAM124A; Family with sequence similarity 124 member A; Belongs to the FAM124 family | 0.715 |
DLEU7 | GPR146 | ENSP00000420976 | ENSP00000380283 | Leukemia-associated protein 7; Deleted in lymphocytic leukemia, 7 | Probable G-protein coupled receptor 146; Orphan receptor; G protein-coupled receptors, Class A orphans | 0.710 |
DLEU7 | KLHL35 | ENSP00000420976 | ENSP00000438526 | Leukemia-associated protein 7; Deleted in lymphocytic leukemia, 7 | Kelch-like protein 35; Kelch like family member 35; BTB domain containing | 0.716 |
DLEU7 | KPNA3 | ENSP00000420976 | ENSP00000261667 | Leukemia-associated protein 7; Deleted in lymphocytic leukemia, 7 | Importin subunit alpha-4; Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta ar [...] | 0.597 |
DLEU7 | PAPOLG | ENSP00000420976 | ENSP00000238714 | Leukemia-associated protein 7; Deleted in lymphocytic leukemia, 7 | Poly(A) polymerase gamma; Responsible for the post-transcriptional adenylation of the 3’-terminal of mRNA precursors and several small RNAs including signal recognition particle (SRP) RNA, nuclear 7SK RNA, U2 small nuclear RNA, and ribosomal 5S RNA | 0.607 |
DLEU7 | RNASEH2B | ENSP00000420976 | ENSP00000337623 | Leukemia-associated protein 7; Deleted in lymphocytic leukemia, 7 | Ribonuclease H2 subunit B; Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA-DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging- strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA-RNA duplexes | 0.600 |
DLEU7 | SETDB2 | ENSP00000420976 | ENSP00000346175 | Leukemia-associated protein 7; Deleted in lymphocytic leukemia, 7 | Histone-lysine N-methyltransferase SETDB2; Histone methyltransferase involved in left-right axis specification in early development and mitosis. Specifically trimethylates ’Lys-9’ of histone H3 (H3K9me3). H3K9me3 is a specific tag for epigenetic transcriptional repression that recruits HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Contributes to H3K9me3 in both the interspersed repetitive elements and centromere-associated repeats. Plays a role in chromosome condensation and segregation during mitosis; Lysine methyltransferases | 0.653 |
FAM124A | DLEU7 | ENSP00000280057 | ENSP00000420976 | Protein FAM124A; Family with sequence similarity 124 member A; Belongs to the FAM124 family | Leukemia-associated protein 7; Deleted in lymphocytic leukemia, 7 | 0.715 |