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  • 11.0 [archived version]
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MAPK4 MAPK4 TET3 TET3 PMEPA1 PMEPA1 TMEM150C TMEM150C ARL4D ARL4D TMEM132E TMEM132E TMEM212 TMEM212 GPR137C GPR137C TMEM171 TMEM171 TMEM211 TMEM211 TMEM221 TMEM221
"TMEM150C" - Transmembrane protein 150C in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
TMEM150CTransmembrane protein 150C; Component of a mechanosensitive cation channel. Confers mechanically activated (MA) currents with slow inactivation kinetics. May contribute to proprioception; Belongs to the DRAM/TMEM150 family (249 aa)    
Predicted Functional Partners:
MAPK4
Mitogen-activated protein kinase 4; Atypical MAPK protein. Phosphorylates microtubule- associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events- upon interaction with atypical MAPKAPK5, ERK4/MAPK4 is phosphorylated at Ser-186 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK4/MAPK4. May promote entry in the cell cycle (By similarity); Mitogen-activated protein kinases (587 aa)
     
   
  0.656
PMEPA1
Protein TMEPAI; Functions as a negative regulator of TGF-beta signaling and thereby probably plays a role in cell proliferation, differentiation, apoptosis, motility, extracellular matrix production and immunosuppression. In the canonical TGF-beta pathway, ZFYVE9/SARA recruits the intracellular signal transducer and transcriptional modulators SMAD2 and SMAD3 to the TGF-beta receptor. Phosphorylated by the receptor, SMAD2 and SMAD3 then form a heteromeric complex with SMAD4 that translocates to the nucleus to regulate transcription. Through interaction with SMAD2 and SMAD3, LDLRAD4 may [...] (287 aa)
           
  0.624
TMEM221
Transmembrane protein 221 (291 aa)
           
  0.601
ARL4D
ADP-ribosylation factor-like protein 4D; Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Recruits CYTH1, CYTH2, CYTH3 and CYTH4 to the plasma membrane in GDP-bound form (201 aa)
           
  0.586
TMEM212
Transmembrane protein 212 (194 aa)
     
   
  0.583
TMEM132E
Transmembrane protein 132E; Required for normal inner ear hair cell function and hearing; Belongs to the TMEM132 family (984 aa)
     
   
  0.582
TMEM211
Transmembrane protein 211 (129 aa)
           
  0.572
GPR137C
Integral membrane protein GPR137C; G protein-coupled receptor 137C (429 aa)
     
   
  0.564
TET3
Methylcytosine dioxygenase TET3; Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5- hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming in the zygote following fertilization. Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation (By similarity). Selectively binds to the promoter region of target genes and contributes to regulate [...] (1795 aa)
           
  0.549
TMEM171
Transmembrane protein 171 (324 aa)
           
  0.545
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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