node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ARL4D | TMEM150C | ENSP00000322628 | ENSP00000420919 | ADP-ribosylation factor-like protein 4D; Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Recruits CYTH1, CYTH2, CYTH3 and CYTH4 to the plasma membrane in GDP-bound form | Transmembrane protein 150C; Component of a mechanosensitive cation channel. Confers mechanically activated (MA) currents with slow inactivation kinetics. May contribute to proprioception; Belongs to the DRAM/TMEM150 family | 0.586 |
GPR137C | TMEM132E | ENSP00000315106 | ENSP00000316532 | Integral membrane protein GPR137C; G protein-coupled receptor 137C | Transmembrane protein 132E; Required for normal inner ear hair cell function and hearing; Belongs to the TMEM132 family | 0.629 |
GPR137C | TMEM150C | ENSP00000315106 | ENSP00000420919 | Integral membrane protein GPR137C; G protein-coupled receptor 137C | Transmembrane protein 150C; Component of a mechanosensitive cation channel. Confers mechanically activated (MA) currents with slow inactivation kinetics. May contribute to proprioception; Belongs to the DRAM/TMEM150 family | 0.564 |
GPR137C | TMEM171 | ENSP00000315106 | ENSP00000415030 | Integral membrane protein GPR137C; G protein-coupled receptor 137C | Transmembrane protein 171 | 0.557 |
GPR137C | TMEM211 | ENSP00000315106 | ENSP00000385494 | Integral membrane protein GPR137C; G protein-coupled receptor 137C | Transmembrane protein 211 | 0.630 |
GPR137C | TMEM212 | ENSP00000315106 | ENSP00000334072 | Integral membrane protein GPR137C; G protein-coupled receptor 137C | Transmembrane protein 212 | 0.633 |
GPR137C | TMEM221 | ENSP00000315106 | ENSP00000342162 | Integral membrane protein GPR137C; G protein-coupled receptor 137C | Transmembrane protein 221 | 0.646 |
MAPK4 | TMEM150C | ENSP00000383234 | ENSP00000420919 | Mitogen-activated protein kinase 4; Atypical MAPK protein. Phosphorylates microtubule- associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events- upon interaction with atypical MAPKAPK5, ERK4/MAPK4 is phosphorylated at Ser-186 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK4/MAPK4. May promote entry in the cell cycle (By similarity); Mitogen-activated protein kinases | Transmembrane protein 150C; Component of a mechanosensitive cation channel. Confers mechanically activated (MA) currents with slow inactivation kinetics. May contribute to proprioception; Belongs to the DRAM/TMEM150 family | 0.656 |
PMEPA1 | TMEM150C | ENSP00000345826 | ENSP00000420919 | Protein TMEPAI; Functions as a negative regulator of TGF-beta signaling and thereby probably plays a role in cell proliferation, differentiation, apoptosis, motility, extracellular matrix production and immunosuppression. In the canonical TGF-beta pathway, ZFYVE9/SARA recruits the intracellular signal transducer and transcriptional modulators SMAD2 and SMAD3 to the TGF-beta receptor. Phosphorylated by the receptor, SMAD2 and SMAD3 then form a heteromeric complex with SMAD4 that translocates to the nucleus to regulate transcription. Through interaction with SMAD2 and SMAD3, LDLRAD4 may [...] | Transmembrane protein 150C; Component of a mechanosensitive cation channel. Confers mechanically activated (MA) currents with slow inactivation kinetics. May contribute to proprioception; Belongs to the DRAM/TMEM150 family | 0.624 |
TET3 | TMEM150C | ENSP00000386869 | ENSP00000420919 | Methylcytosine dioxygenase TET3; Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5- hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming in the zygote following fertilization. Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation (By similarity). Selectively binds to the promoter region of target genes and contributes to regulate [...] | Transmembrane protein 150C; Component of a mechanosensitive cation channel. Confers mechanically activated (MA) currents with slow inactivation kinetics. May contribute to proprioception; Belongs to the DRAM/TMEM150 family | 0.549 |
TMEM132E | GPR137C | ENSP00000316532 | ENSP00000315106 | Transmembrane protein 132E; Required for normal inner ear hair cell function and hearing; Belongs to the TMEM132 family | Integral membrane protein GPR137C; G protein-coupled receptor 137C | 0.629 |
TMEM132E | TMEM150C | ENSP00000316532 | ENSP00000420919 | Transmembrane protein 132E; Required for normal inner ear hair cell function and hearing; Belongs to the TMEM132 family | Transmembrane protein 150C; Component of a mechanosensitive cation channel. Confers mechanically activated (MA) currents with slow inactivation kinetics. May contribute to proprioception; Belongs to the DRAM/TMEM150 family | 0.582 |
TMEM132E | TMEM171 | ENSP00000316532 | ENSP00000415030 | Transmembrane protein 132E; Required for normal inner ear hair cell function and hearing; Belongs to the TMEM132 family | Transmembrane protein 171 | 0.549 |
TMEM132E | TMEM211 | ENSP00000316532 | ENSP00000385494 | Transmembrane protein 132E; Required for normal inner ear hair cell function and hearing; Belongs to the TMEM132 family | Transmembrane protein 211 | 0.650 |
TMEM132E | TMEM212 | ENSP00000316532 | ENSP00000334072 | Transmembrane protein 132E; Required for normal inner ear hair cell function and hearing; Belongs to the TMEM132 family | Transmembrane protein 212 | 0.659 |
TMEM132E | TMEM221 | ENSP00000316532 | ENSP00000342162 | Transmembrane protein 132E; Required for normal inner ear hair cell function and hearing; Belongs to the TMEM132 family | Transmembrane protein 221 | 0.617 |
TMEM150C | ARL4D | ENSP00000420919 | ENSP00000322628 | Transmembrane protein 150C; Component of a mechanosensitive cation channel. Confers mechanically activated (MA) currents with slow inactivation kinetics. May contribute to proprioception; Belongs to the DRAM/TMEM150 family | ADP-ribosylation factor-like protein 4D; Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Recruits CYTH1, CYTH2, CYTH3 and CYTH4 to the plasma membrane in GDP-bound form | 0.586 |
TMEM150C | GPR137C | ENSP00000420919 | ENSP00000315106 | Transmembrane protein 150C; Component of a mechanosensitive cation channel. Confers mechanically activated (MA) currents with slow inactivation kinetics. May contribute to proprioception; Belongs to the DRAM/TMEM150 family | Integral membrane protein GPR137C; G protein-coupled receptor 137C | 0.564 |
TMEM150C | MAPK4 | ENSP00000420919 | ENSP00000383234 | Transmembrane protein 150C; Component of a mechanosensitive cation channel. Confers mechanically activated (MA) currents with slow inactivation kinetics. May contribute to proprioception; Belongs to the DRAM/TMEM150 family | Mitogen-activated protein kinase 4; Atypical MAPK protein. Phosphorylates microtubule- associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events- upon interaction with atypical MAPKAPK5, ERK4/MAPK4 is phosphorylated at Ser-186 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK4/MAPK4. May promote entry in the cell cycle (By similarity); Mitogen-activated protein kinases | 0.656 |
TMEM150C | PMEPA1 | ENSP00000420919 | ENSP00000345826 | Transmembrane protein 150C; Component of a mechanosensitive cation channel. Confers mechanically activated (MA) currents with slow inactivation kinetics. May contribute to proprioception; Belongs to the DRAM/TMEM150 family | Protein TMEPAI; Functions as a negative regulator of TGF-beta signaling and thereby probably plays a role in cell proliferation, differentiation, apoptosis, motility, extracellular matrix production and immunosuppression. In the canonical TGF-beta pathway, ZFYVE9/SARA recruits the intracellular signal transducer and transcriptional modulators SMAD2 and SMAD3 to the TGF-beta receptor. Phosphorylated by the receptor, SMAD2 and SMAD3 then form a heteromeric complex with SMAD4 that translocates to the nucleus to regulate transcription. Through interaction with SMAD2 and SMAD3, LDLRAD4 may [...] | 0.624 |