• Version:
  • 11.0 [archived version]
STRINGSTRING
RIMS3 RIMS3 TPCN1 TPCN1 TSKU TSKU NIM1K NIM1K ZNF131 ZNF131 PARP8 PARP8 CCDC152 CCDC152 WEE1 WEE1 WDR70 WDR70 NUP155 NUP155 GPR26 GPR26
"NIM1K" - NIM1 serine/threonine protein kinase in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Gene Fusion
Cooccurence
Coexpression
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[Homology]
Score
NIM1KNIM1 serine/threonine protein kinase (436 aa)    
Predicted Functional Partners:
WEE1
Wee1-like protein kinase; Acts as a negative regulator of entry into mitosis (G2 to M transition) by protecting the nucleus from cytoplasmically activated cyclin B1-complexed CDK1 before the onset of mitosis by mediating phosphorylation of CDK1 on ’Tyr-15’. Specifically phosphorylates and inactivates cyclin B1-complexed CDK1 reaching a maximum during G2 phase and a minimum as cells enter M phase. Phosphorylation of cyclin B1-CDK1 occurs exclusively on ’Tyr-15’ and phosphorylation of monomeric CDK1 does not occur. Its activity increases during S and G2 phases and decreases at M phase wh [...] (646 aa)
       
 
  0.751
CCDC152
Coiled-coil domain containing 152 (254 aa)
           
  0.582
TPCN1
Two pore calcium channel protein 1; Nicotinic acid adenine dinucleotide phosphate (NAADP) receptor that may function as one of the major voltage-gated Ca(2+) channels (VDCC) across the lysosomal and endosomal membrane; Two pore segment channels (888 aa)
     
   
  0.571
ZNF131
Zinc finger protein 131; Plays a role during development and organogenesis as well as in the function of the adult central nervous system (By similarity). May be involved in transcriptional regulation as a repressor of ESR1/ER-alpha signaling; BTB domain containing (589 aa)
     
 
  0.568
WDR70
WD repeat-containing protein 70; WD repeat domain containing; Belongs to the WD repeat GAD-1 family (654 aa)
           
  0.558
TSKU
Tsukushin; Tsukushi, small leucine rich proteoglycan (353 aa)
       
 
  0.531
RIMS3
Regulating synaptic membrane exocytosis protein 3; Regulates synaptic membrane exocytosis (308 aa)
     
   
  0.520
NUP155
Nuclear pore complex protein Nup155; Essential component of nuclear pore complex. Could be essessential for embryogenesis. Nucleoporins may be involved both in binding and translocating proteins during nucleocytoplasmic transport (1391 aa)
     
 
  0.480
GPR26
G-protein coupled receptor 26; Orphan receptor. Displays a significant level of constitutive activity. Its effect is mediated by G(s)-alpha protein that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP; G protein-coupled receptors, Class A orphans (337 aa)
     
   
  0.479
PARP8
poly(ADP-ribose) polymerase family member 8 (854 aa)
           
  0.477
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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