| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| C4BPA | PRB1 | ENSP00000356037 | ENSP00000420826 | C4b-binding protein alpha chain; Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It interacts also with anticoagulant protein S and with serum amyloid P component; Sushi domain containing | Basic salivary proline-rich protein 1; Proline rich protein BstNI subfamily 1 | 0.542 |
| C4BPA | PRB2 | ENSP00000356037 | ENSP00000374013 | C4b-binding protein alpha chain; Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It interacts also with anticoagulant protein S and with serum amyloid P component; Sushi domain containing | Basic salivary proline-rich protein 2; Proline rich protein BstNI subfamily 2 | 0.474 |
| C4BPA | PRB4 | ENSP00000356037 | ENSP00000279575 | C4b-binding protein alpha chain; Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It interacts also with anticoagulant protein S and with serum amyloid P component; Sushi domain containing | Basic salivary proline-rich protein 4; Proline rich protein BstNI subfamily 4 | 0.719 |
| C4BPA | PRH2 | ENSP00000356037 | ENSP00000379682 | C4b-binding protein alpha chain; Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It interacts also with anticoagulant protein S and with serum amyloid P component; Sushi domain containing | Salivary acidic proline-rich phosphoprotein 1/2; PRP’s act as highly potent inhibitors of crystal growth of calcium phosphates. They provide a protective and reparative environment for dental enamel which is important for the integrity of the teeth; Proline rich proteins | 0.755 |
| C4BPA | PROL1 | ENSP00000356037 | ENSP00000382485 | C4b-binding protein alpha chain; Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It interacts also with anticoagulant protein S and with serum amyloid P component; Sushi domain containing | Opiorphin prepropeptide; Opiorphin is an endogenous inhibitor of neprilysin and aminopeptidase N. Inhibits the breakdown of substance P, Mca-BK2 and Met-enkephalin by neprilysin in vitro with IC(50) values of 29 uM, 33 uM and 33 uM respectively. Inhibits the breakdown of Ala- pNA by aminopeptidase N in vitro with an IC(50) of 65 uM. Has a potent analgesic effect when administered to rats by intravenous injection; Belongs to the PROL1/PROL3 family | 0.442 |
| C4BPA | RB1 | ENSP00000356037 | ENSP00000267163 | C4b-binding protein alpha chain; Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It interacts also with anticoagulant protein S and with serum amyloid P component; Sushi domain containing | Retinoblastoma-associated protein; Key regulator of entry into cell division that acts as a tumor suppressor. Promotes G0-G1 transition when phosphorylated by CDK3/cyclin-C. Acts as a transcription repressor of E2F1 target genes. The underphosphorylated, active form of RB1 interacts with E2F1 and represses its transcription activity, leading to cell cycle arrest. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransfer [...] | 0.442 |
| GTF2B | PRB1 | ENSP00000359531 | ENSP00000420826 | Transcription initiation factor IIB; General factor that plays a major role in the activation of eukaryotic genes transcribed by RNA polymerase II; Belongs to the TFIIB family | Basic salivary proline-rich protein 1; Proline rich protein BstNI subfamily 1 | 0.519 |
| PLGLB1 | PRB1 | ENSP00000347933 | ENSP00000420826 | Plasminogen-like B1; May bind noncovalently to lysine binding sites present in the kringle structures of plasminogen. This may interfere with the binding of fibrin or alpha-2-antiplasmin to plasminogen and may result in the localization of activity at sites necessary for extracellular matrix destruction | Basic salivary proline-rich protein 1; Proline rich protein BstNI subfamily 1 | 0.710 |
| PLGLB1 | PROL1 | ENSP00000347933 | ENSP00000382485 | Plasminogen-like B1; May bind noncovalently to lysine binding sites present in the kringle structures of plasminogen. This may interfere with the binding of fibrin or alpha-2-antiplasmin to plasminogen and may result in the localization of activity at sites necessary for extracellular matrix destruction | Opiorphin prepropeptide; Opiorphin is an endogenous inhibitor of neprilysin and aminopeptidase N. Inhibits the breakdown of substance P, Mca-BK2 and Met-enkephalin by neprilysin in vitro with IC(50) values of 29 uM, 33 uM and 33 uM respectively. Inhibits the breakdown of Ala- pNA by aminopeptidase N in vitro with an IC(50) of 65 uM. Has a potent analgesic effect when administered to rats by intravenous injection; Belongs to the PROL1/PROL3 family | 0.716 |
| PLGLB1 | ZP2 | ENSP00000347933 | ENSP00000460971 | Plasminogen-like B1; May bind noncovalently to lysine binding sites present in the kringle structures of plasminogen. This may interfere with the binding of fibrin or alpha-2-antiplasmin to plasminogen and may result in the localization of activity at sites necessary for extracellular matrix destruction | Zona pellucida sperm-binding protein 2; The mammalian zona pellucida, which mediates species- specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP2 may act as a secondary sperm receptor | 0.633 |
| PRB1 | C4BPA | ENSP00000420826 | ENSP00000356037 | Basic salivary proline-rich protein 1; Proline rich protein BstNI subfamily 1 | C4b-binding protein alpha chain; Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It interacts also with anticoagulant protein S and with serum amyloid P component; Sushi domain containing | 0.542 |
| PRB1 | GTF2B | ENSP00000420826 | ENSP00000359531 | Basic salivary proline-rich protein 1; Proline rich protein BstNI subfamily 1 | Transcription initiation factor IIB; General factor that plays a major role in the activation of eukaryotic genes transcribed by RNA polymerase II; Belongs to the TFIIB family | 0.519 |
| PRB1 | PLGLB1 | ENSP00000420826 | ENSP00000347933 | Basic salivary proline-rich protein 1; Proline rich protein BstNI subfamily 1 | Plasminogen-like B1; May bind noncovalently to lysine binding sites present in the kringle structures of plasminogen. This may interfere with the binding of fibrin or alpha-2-antiplasmin to plasminogen and may result in the localization of activity at sites necessary for extracellular matrix destruction | 0.710 |
| PRB1 | PRB2 | ENSP00000420826 | ENSP00000374013 | Basic salivary proline-rich protein 1; Proline rich protein BstNI subfamily 1 | Basic salivary proline-rich protein 2; Proline rich protein BstNI subfamily 2 | 0.823 |
| PRB1 | PRB4 | ENSP00000420826 | ENSP00000279575 | Basic salivary proline-rich protein 1; Proline rich protein BstNI subfamily 1 | Basic salivary proline-rich protein 4; Proline rich protein BstNI subfamily 4 | 0.839 |
| PRB1 | PRH2 | ENSP00000420826 | ENSP00000379682 | Basic salivary proline-rich protein 1; Proline rich protein BstNI subfamily 1 | Salivary acidic proline-rich phosphoprotein 1/2; PRP’s act as highly potent inhibitors of crystal growth of calcium phosphates. They provide a protective and reparative environment for dental enamel which is important for the integrity of the teeth; Proline rich proteins | 0.755 |
| PRB1 | PROL1 | ENSP00000420826 | ENSP00000382485 | Basic salivary proline-rich protein 1; Proline rich protein BstNI subfamily 1 | Opiorphin prepropeptide; Opiorphin is an endogenous inhibitor of neprilysin and aminopeptidase N. Inhibits the breakdown of substance P, Mca-BK2 and Met-enkephalin by neprilysin in vitro with IC(50) values of 29 uM, 33 uM and 33 uM respectively. Inhibits the breakdown of Ala- pNA by aminopeptidase N in vitro with an IC(50) of 65 uM. Has a potent analgesic effect when administered to rats by intravenous injection; Belongs to the PROL1/PROL3 family | 0.650 |
| PRB1 | RB1 | ENSP00000420826 | ENSP00000267163 | Basic salivary proline-rich protein 1; Proline rich protein BstNI subfamily 1 | Retinoblastoma-associated protein; Key regulator of entry into cell division that acts as a tumor suppressor. Promotes G0-G1 transition when phosphorylated by CDK3/cyclin-C. Acts as a transcription repressor of E2F1 target genes. The underphosphorylated, active form of RB1 interacts with E2F1 and represses its transcription activity, leading to cell cycle arrest. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransfer [...] | 0.641 |
| PRB1 | SFTPA2 | ENSP00000420826 | ENSP00000361400 | Basic salivary proline-rich protein 1; Proline rich protein BstNI subfamily 1 | Pulmonary surfactant-associated protein A2; In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air-liquid interface in the alveoli of the mammalian lung and is essential for normal respiration; C-type lectin domain containing | 0.499 |
| PRB1 | ZP2 | ENSP00000420826 | ENSP00000460971 | Basic salivary proline-rich protein 1; Proline rich protein BstNI subfamily 1 | Zona pellucida sperm-binding protein 2; The mammalian zona pellucida, which mediates species- specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP2 may act as a secondary sperm receptor | 0.533 |
