| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ABAT | C1orf228 | ENSP00000379845 | ENSP00000420716 | 4-aminobutyrate aminotransferase, mitochondrial; Catalyzes the conversion of gamma-aminobutyrate and L- beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively. Can also convert delta-aminovalerate and beta-alanine; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family | Uncharacterized protein C1orf228; Chromosome 1 open reading frame 228 | 0.685 |
| C1orf228 | ABAT | ENSP00000420716 | ENSP00000379845 | Uncharacterized protein C1orf228; Chromosome 1 open reading frame 228 | 4-aminobutyrate aminotransferase, mitochondrial; Catalyzes the conversion of gamma-aminobutyrate and L- beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively. Can also convert delta-aminovalerate and beta-alanine; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family | 0.685 |
| C1orf228 | EPPK1 | ENSP00000420716 | ENSP00000484472 | Uncharacterized protein C1orf228; Chromosome 1 open reading frame 228 | Epiplakin; Cytoskeletal linker protein that connects to intermediate filaments and controls their reorganization in response to stress. In response to mechanical stress like wound healing, is associated with the machinery for cellular motility by slowing down keratinocyte migration and proliferation and accelerating keratin bundling in proliferating keratinocytes thus contributing to tissue architecture. However in wound healing in corneal epithelium also positively regulates cell differentiation and proliferation and negatively regulates migration thereby controlling corneal epitheliu [...] | 0.412 |
| C1orf228 | FKBP11 | ENSP00000420716 | ENSP00000449751 | Uncharacterized protein C1orf228; Chromosome 1 open reading frame 228 | Peptidyl-prolyl cis-trans isomerase FKBP11; PPIases accelerate the folding of proteins during protein synthesis; FKBP prolyl isomerases | 0.426 |
| C1orf228 | MCF2L | ENSP00000420716 | ENSP00000440374 | Uncharacterized protein C1orf228; Chromosome 1 open reading frame 228 | Guanine nucleotide exchange factor DBS; Guanine nucleotide exchange factor that catalyzes guanine nucleotide exchange on RHOA and CDC42, and thereby contributes to the regulation of RHOA and CDC42 signaling pathways (By similarity). Seems to lack activity with RAC1. Becomes activated and highly tumorigenic by truncation of the N-terminus (By similarity). Isoform 5 activates CDC42; Pleckstrin homology domain containing | 0.420 |
| C1orf228 | NRBP2 | ENSP00000420716 | ENSP00000414055 | Uncharacterized protein C1orf228; Chromosome 1 open reading frame 228 | Nuclear receptor-binding protein 2; May regulate apoptosis of neural progenitor cells during their differentiation; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family | 0.587 |
| C1orf228 | PUF60 | ENSP00000420716 | ENSP00000434359 | Uncharacterized protein C1orf228; Chromosome 1 open reading frame 228 | Poly(U)-binding-splicing factor PUF60; DNA- and RNA-binding protein, involved in several nuclear processes such as pre-mRNA splicing, apoptosis and transcription regulation. In association with FUBP1 regulates MYC transcription at the P2 promoter through the core-TFIIH basal transcription factor. Acts as a transcriptional repressor through the core-TFIIH basal transcription factor. Represses FUBP1-induced transcriptional activation but not basal transcription. Decreases ERCC3 helicase activity. Does not repress TFIIH-mediated transcription in xeroderma pigmentosum complementation group [...] | 0.418 |
| C1orf228 | RHBDD3 | ENSP00000420716 | ENSP00000216085 | Uncharacterized protein C1orf228; Chromosome 1 open reading frame 228 | Rhomboid domain containing 3 | 0.473 |
| C1orf228 | RNF220 | ENSP00000420716 | ENSP00000347548 | Uncharacterized protein C1orf228; Chromosome 1 open reading frame 228 | E3 ubiquitin-protein ligase RNF220; E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of SIN3B (By similarity). Independently of its E3 ligase activity, acts as a CTNNB1 stabilizer through USP7-mediated deubiquitination of CTNNB1 promoting Wnt signaling; Ring finger proteins | 0.528 |
| C1orf228 | SLC22A14 | ENSP00000420716 | ENSP00000273173 | Uncharacterized protein C1orf228; Chromosome 1 open reading frame 228 | Solute carrier family 22 member 14; Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family | 0.549 |
| C1orf228 | TMEM53 | ENSP00000420716 | ENSP00000361311 | Uncharacterized protein C1orf228; Chromosome 1 open reading frame 228 | Transmembrane protein 53; Belongs to the TMEM53 family | 0.630 |
| EPPK1 | C1orf228 | ENSP00000484472 | ENSP00000420716 | Epiplakin; Cytoskeletal linker protein that connects to intermediate filaments and controls their reorganization in response to stress. In response to mechanical stress like wound healing, is associated with the machinery for cellular motility by slowing down keratinocyte migration and proliferation and accelerating keratin bundling in proliferating keratinocytes thus contributing to tissue architecture. However in wound healing in corneal epithelium also positively regulates cell differentiation and proliferation and negatively regulates migration thereby controlling corneal epitheliu [...] | Uncharacterized protein C1orf228; Chromosome 1 open reading frame 228 | 0.412 |
| EPPK1 | MCF2L | ENSP00000484472 | ENSP00000440374 | Epiplakin; Cytoskeletal linker protein that connects to intermediate filaments and controls their reorganization in response to stress. In response to mechanical stress like wound healing, is associated with the machinery for cellular motility by slowing down keratinocyte migration and proliferation and accelerating keratin bundling in proliferating keratinocytes thus contributing to tissue architecture. However in wound healing in corneal epithelium also positively regulates cell differentiation and proliferation and negatively regulates migration thereby controlling corneal epitheliu [...] | Guanine nucleotide exchange factor DBS; Guanine nucleotide exchange factor that catalyzes guanine nucleotide exchange on RHOA and CDC42, and thereby contributes to the regulation of RHOA and CDC42 signaling pathways (By similarity). Seems to lack activity with RAC1. Becomes activated and highly tumorigenic by truncation of the N-terminus (By similarity). Isoform 5 activates CDC42; Pleckstrin homology domain containing | 0.572 |
| EPPK1 | NRBP2 | ENSP00000484472 | ENSP00000414055 | Epiplakin; Cytoskeletal linker protein that connects to intermediate filaments and controls their reorganization in response to stress. In response to mechanical stress like wound healing, is associated with the machinery for cellular motility by slowing down keratinocyte migration and proliferation and accelerating keratin bundling in proliferating keratinocytes thus contributing to tissue architecture. However in wound healing in corneal epithelium also positively regulates cell differentiation and proliferation and negatively regulates migration thereby controlling corneal epitheliu [...] | Nuclear receptor-binding protein 2; May regulate apoptosis of neural progenitor cells during their differentiation; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family | 0.658 |
| EPPK1 | PUF60 | ENSP00000484472 | ENSP00000434359 | Epiplakin; Cytoskeletal linker protein that connects to intermediate filaments and controls their reorganization in response to stress. In response to mechanical stress like wound healing, is associated with the machinery for cellular motility by slowing down keratinocyte migration and proliferation and accelerating keratin bundling in proliferating keratinocytes thus contributing to tissue architecture. However in wound healing in corneal epithelium also positively regulates cell differentiation and proliferation and negatively regulates migration thereby controlling corneal epitheliu [...] | Poly(U)-binding-splicing factor PUF60; DNA- and RNA-binding protein, involved in several nuclear processes such as pre-mRNA splicing, apoptosis and transcription regulation. In association with FUBP1 regulates MYC transcription at the P2 promoter through the core-TFIIH basal transcription factor. Acts as a transcriptional repressor through the core-TFIIH basal transcription factor. Represses FUBP1-induced transcriptional activation but not basal transcription. Decreases ERCC3 helicase activity. Does not repress TFIIH-mediated transcription in xeroderma pigmentosum complementation group [...] | 0.664 |
| EPPK1 | RNF220 | ENSP00000484472 | ENSP00000347548 | Epiplakin; Cytoskeletal linker protein that connects to intermediate filaments and controls their reorganization in response to stress. In response to mechanical stress like wound healing, is associated with the machinery for cellular motility by slowing down keratinocyte migration and proliferation and accelerating keratin bundling in proliferating keratinocytes thus contributing to tissue architecture. However in wound healing in corneal epithelium also positively regulates cell differentiation and proliferation and negatively regulates migration thereby controlling corneal epitheliu [...] | E3 ubiquitin-protein ligase RNF220; E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of SIN3B (By similarity). Independently of its E3 ligase activity, acts as a CTNNB1 stabilizer through USP7-mediated deubiquitination of CTNNB1 promoting Wnt signaling; Ring finger proteins | 0.641 |
| EPPK1 | TMEM53 | ENSP00000484472 | ENSP00000361311 | Epiplakin; Cytoskeletal linker protein that connects to intermediate filaments and controls their reorganization in response to stress. In response to mechanical stress like wound healing, is associated with the machinery for cellular motility by slowing down keratinocyte migration and proliferation and accelerating keratin bundling in proliferating keratinocytes thus contributing to tissue architecture. However in wound healing in corneal epithelium also positively regulates cell differentiation and proliferation and negatively regulates migration thereby controlling corneal epitheliu [...] | Transmembrane protein 53; Belongs to the TMEM53 family | 0.667 |
| FKBP11 | C1orf228 | ENSP00000449751 | ENSP00000420716 | Peptidyl-prolyl cis-trans isomerase FKBP11; PPIases accelerate the folding of proteins during protein synthesis; FKBP prolyl isomerases | Uncharacterized protein C1orf228; Chromosome 1 open reading frame 228 | 0.426 |
| MCF2L | C1orf228 | ENSP00000440374 | ENSP00000420716 | Guanine nucleotide exchange factor DBS; Guanine nucleotide exchange factor that catalyzes guanine nucleotide exchange on RHOA and CDC42, and thereby contributes to the regulation of RHOA and CDC42 signaling pathways (By similarity). Seems to lack activity with RAC1. Becomes activated and highly tumorigenic by truncation of the N-terminus (By similarity). Isoform 5 activates CDC42; Pleckstrin homology domain containing | Uncharacterized protein C1orf228; Chromosome 1 open reading frame 228 | 0.420 |
| MCF2L | EPPK1 | ENSP00000440374 | ENSP00000484472 | Guanine nucleotide exchange factor DBS; Guanine nucleotide exchange factor that catalyzes guanine nucleotide exchange on RHOA and CDC42, and thereby contributes to the regulation of RHOA and CDC42 signaling pathways (By similarity). Seems to lack activity with RAC1. Becomes activated and highly tumorigenic by truncation of the N-terminus (By similarity). Isoform 5 activates CDC42; Pleckstrin homology domain containing | Epiplakin; Cytoskeletal linker protein that connects to intermediate filaments and controls their reorganization in response to stress. In response to mechanical stress like wound healing, is associated with the machinery for cellular motility by slowing down keratinocyte migration and proliferation and accelerating keratin bundling in proliferating keratinocytes thus contributing to tissue architecture. However in wound healing in corneal epithelium also positively regulates cell differentiation and proliferation and negatively regulates migration thereby controlling corneal epitheliu [...] | 0.572 |
