| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| DDX17 | ZNF398 | ENSP00000380033 | ENSP00000420418 | Probable ATP-dependent RNA helicase DDX17; As an RNA helicase, unwinds RNA and alters RNA structures through ATP binding and hydrolysis. Involved in multiple cellular processes, including pre-mRNA splicing, alternative splicing, ribosomal RNA processing and miRNA processing, as well as transcription regulation. Regulates the alternative splicing of exons exhibiting specific features. For instance, promotes the inclusion of AC-rich alternative exons in CD44 transcripts. This function requires the RNA helicase activity. Affects NFAT5 and histone macro-H2A.1/H2AFY alternative splicing in [...] | Zinc finger protein 398; Function as a transcriptional activator; Zinc fingers C2H2-type | 0.673 |
| PPCDC | ZNF398 | ENSP00000343190 | ENSP00000420418 | Phosphopantothenoylcysteine decarboxylase; Necessary for the biosynthesis of coenzyme A. Catalyzes the decarboxylation of 4-phosphopantothenoylcysteine to form 4’- phosphopantotheine | Zinc finger protein 398; Function as a transcriptional activator; Zinc fingers C2H2-type | 0.639 |
| TCEAL8 | ZNF398 | ENSP00000361770 | ENSP00000420418 | Transcription elongation factor A protein-like 8; May be involved in transcriptional regulation; Transcription elongation factor A like family | Zinc finger protein 398; Function as a transcriptional activator; Zinc fingers C2H2-type | 0.594 |
| TRIM28 | ZNF212 | ENSP00000253024 | ENSP00000338572 | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at ’Lys-9’ (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 ’Lys-9 and ’Lys-14’ acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | Zinc finger protein 212; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.927 |
| TRIM28 | ZNF282 | ENSP00000253024 | ENSP00000477841 | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at ’Lys-9’ (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 ’Lys-9 and ’Lys-14’ acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | Zinc finger protein 282; Binds to the U5 repressive element (U5RE) of the human T cell leukemia virus type I long terminal repeat. It recognizes the 5’-TCCACCCC-3’ sequence as a core motif and exerts a strong repressive effect on HTLV-I LTR-mediated expression; Belongs to the krueppel C2H2-type zinc-finger protein family | 0.947 |
| TRIM28 | ZNF398 | ENSP00000253024 | ENSP00000420418 | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at ’Lys-9’ (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 ’Lys-9 and ’Lys-14’ acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | Zinc finger protein 398; Function as a transcriptional activator; Zinc fingers C2H2-type | 0.905 |
| TRIM28 | ZNF746 | ENSP00000253024 | ENSP00000395007 | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at ’Lys-9’ (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 ’Lys-9 and ’Lys-14’ acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | Zinc finger protein 746; Transcription repressor that specifically binds to the 5’-TATTTT[T/G]-3’ consensus sequence on promoters and repress transcription of PGC-1-alpha (PPARGC1A), thereby playing a role in regulation of neuron death; Zinc fingers C2H2-type | 0.921 |
| TRIM28 | ZNF777 | ENSP00000253024 | ENSP00000247930 | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at ’Lys-9’ (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 ’Lys-9 and ’Lys-14’ acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | Zinc finger protein 777; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.918 |
| UGGT2 | ZNF398 | ENSP00000365938 | ENSP00000420418 | UDP-glucose-glycoprotein glucosyltransferase 2; Recognizes glycoproteins with minor folding defects. Reglucosylates single N-glycans near the misfolded part of the protein, thus providing quality control for protein folding in the endoplasmic reticulum. Reglucosylated proteins are recognized by calreticulin for recycling to the endoplasmic reticulum and refolding or degradation (By similarity); Belongs to the glycosyltransferase 8 family | Zinc finger protein 398; Function as a transcriptional activator; Zinc fingers C2H2-type | 0.572 |
| ZNF212 | TRIM28 | ENSP00000338572 | ENSP00000253024 | Zinc finger protein 212; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at ’Lys-9’ (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 ’Lys-9 and ’Lys-14’ acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | 0.927 |
| ZNF212 | ZNF282 | ENSP00000338572 | ENSP00000477841 | Zinc finger protein 212; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Zinc finger protein 282; Binds to the U5 repressive element (U5RE) of the human T cell leukemia virus type I long terminal repeat. It recognizes the 5’-TCCACCCC-3’ sequence as a core motif and exerts a strong repressive effect on HTLV-I LTR-mediated expression; Belongs to the krueppel C2H2-type zinc-finger protein family | 0.884 |
| ZNF212 | ZNF398 | ENSP00000338572 | ENSP00000420418 | Zinc finger protein 212; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Zinc finger protein 398; Function as a transcriptional activator; Zinc fingers C2H2-type | 0.869 |
| ZNF212 | ZNF746 | ENSP00000338572 | ENSP00000395007 | Zinc finger protein 212; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Zinc finger protein 746; Transcription repressor that specifically binds to the 5’-TATTTT[T/G]-3’ consensus sequence on promoters and repress transcription of PGC-1-alpha (PPARGC1A), thereby playing a role in regulation of neuron death; Zinc fingers C2H2-type | 0.847 |
| ZNF212 | ZNF777 | ENSP00000338572 | ENSP00000247930 | Zinc finger protein 212; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Zinc finger protein 777; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.825 |
| ZNF282 | TRIM28 | ENSP00000477841 | ENSP00000253024 | Zinc finger protein 282; Binds to the U5 repressive element (U5RE) of the human T cell leukemia virus type I long terminal repeat. It recognizes the 5’-TCCACCCC-3’ sequence as a core motif and exerts a strong repressive effect on HTLV-I LTR-mediated expression; Belongs to the krueppel C2H2-type zinc-finger protein family | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at ’Lys-9’ (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 ’Lys-9 and ’Lys-14’ acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | 0.947 |
| ZNF282 | ZNF212 | ENSP00000477841 | ENSP00000338572 | Zinc finger protein 282; Binds to the U5 repressive element (U5RE) of the human T cell leukemia virus type I long terminal repeat. It recognizes the 5’-TCCACCCC-3’ sequence as a core motif and exerts a strong repressive effect on HTLV-I LTR-mediated expression; Belongs to the krueppel C2H2-type zinc-finger protein family | Zinc finger protein 212; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.884 |
| ZNF282 | ZNF398 | ENSP00000477841 | ENSP00000420418 | Zinc finger protein 282; Binds to the U5 repressive element (U5RE) of the human T cell leukemia virus type I long terminal repeat. It recognizes the 5’-TCCACCCC-3’ sequence as a core motif and exerts a strong repressive effect on HTLV-I LTR-mediated expression; Belongs to the krueppel C2H2-type zinc-finger protein family | Zinc finger protein 398; Function as a transcriptional activator; Zinc fingers C2H2-type | 0.825 |
| ZNF398 | DDX17 | ENSP00000420418 | ENSP00000380033 | Zinc finger protein 398; Function as a transcriptional activator; Zinc fingers C2H2-type | Probable ATP-dependent RNA helicase DDX17; As an RNA helicase, unwinds RNA and alters RNA structures through ATP binding and hydrolysis. Involved in multiple cellular processes, including pre-mRNA splicing, alternative splicing, ribosomal RNA processing and miRNA processing, as well as transcription regulation. Regulates the alternative splicing of exons exhibiting specific features. For instance, promotes the inclusion of AC-rich alternative exons in CD44 transcripts. This function requires the RNA helicase activity. Affects NFAT5 and histone macro-H2A.1/H2AFY alternative splicing in [...] | 0.673 |
| ZNF398 | PPCDC | ENSP00000420418 | ENSP00000343190 | Zinc finger protein 398; Function as a transcriptional activator; Zinc fingers C2H2-type | Phosphopantothenoylcysteine decarboxylase; Necessary for the biosynthesis of coenzyme A. Catalyzes the decarboxylation of 4-phosphopantothenoylcysteine to form 4’- phosphopantotheine | 0.639 |
| ZNF398 | TCEAL8 | ENSP00000420418 | ENSP00000361770 | Zinc finger protein 398; Function as a transcriptional activator; Zinc fingers C2H2-type | Transcription elongation factor A protein-like 8; May be involved in transcriptional regulation; Transcription elongation factor A like family | 0.594 |
