| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CGB8 | ERVFRD-1 | ENSP00000403649 | ENSP00000420174 | Choriogonadotropin subunit beta variant 2; Chorionic gonadotropin beta subunit 8; Belongs to the glycoprotein hormones subunit beta family | Syncytin-2; This endogenous retroviral envelope protein has retained its original fusogenic properties and participates in trophoblast fusion and the formation of a syncytium during placenta morphogenesis. The interaction with MFSD2A is apparently important for this process | 0.428 |
| CGB8 | GCM1 | ENSP00000403649 | ENSP00000259803 | Choriogonadotropin subunit beta variant 2; Chorionic gonadotropin beta subunit 8; Belongs to the glycoprotein hormones subunit beta family | Chorion-specific transcription factor GCMa; Transcription factor involved in the control of expression of placental growth factor (PGF) and other placenta- specific genes. Binds to the trophoblast-specific element 2 (TSE2) of the aromatase gene enhancer. Binds to the SYDE1 promoter. Has a central role in mediating the differentiation of trophoblast cells along both the villous and extravillous pathways in placental development | 0.520 |
| CLEC10A | ERVFRD-1 | ENSP00000254868 | ENSP00000420174 | C-type lectin domain family 10 member A; Probable role in regulating adaptive and innate immune responses. Binds in a calcium-dependent manner to terminal galactose and N-acetylgalactosamine units, linked to serine or threonine. These sugar moieties are known as Tn-Ag and are expressed in a variety of carcinoma cells; C-type lectin domain containing | Syncytin-2; This endogenous retroviral envelope protein has retained its original fusogenic properties and participates in trophoblast fusion and the formation of a syncytium during placenta morphogenesis. The interaction with MFSD2A is apparently important for this process | 0.618 |
| CTBS | ERVFRD-1 | ENSP00000359664 | ENSP00000420174 | Di-N-acetylchitobiase; Involved in the degradation of asparagine-linked glycoproteins. Hydrolyze of N-acetyl-beta-D-glucosamine (1-4)N- acetylglucosamine chitobiose core from the reducing end of the bond, it requires prior cleavage by glycosylasparaginase; Chitinases | Syncytin-2; This endogenous retroviral envelope protein has retained its original fusogenic properties and participates in trophoblast fusion and the formation of a syncytium during placenta morphogenesis. The interaction with MFSD2A is apparently important for this process | 0.471 |
| CTBS | GCM1 | ENSP00000359664 | ENSP00000259803 | Di-N-acetylchitobiase; Involved in the degradation of asparagine-linked glycoproteins. Hydrolyze of N-acetyl-beta-D-glucosamine (1-4)N- acetylglucosamine chitobiose core from the reducing end of the bond, it requires prior cleavage by glycosylasparaginase; Chitinases | Chorion-specific transcription factor GCMa; Transcription factor involved in the control of expression of placental growth factor (PGF) and other placenta- specific genes. Binds to the trophoblast-specific element 2 (TSE2) of the aromatase gene enhancer. Binds to the SYDE1 promoter. Has a central role in mediating the differentiation of trophoblast cells along both the villous and extravillous pathways in placental development | 0.569 |
| ERVFRD-1 | CGB8 | ENSP00000420174 | ENSP00000403649 | Syncytin-2; This endogenous retroviral envelope protein has retained its original fusogenic properties and participates in trophoblast fusion and the formation of a syncytium during placenta morphogenesis. The interaction with MFSD2A is apparently important for this process | Choriogonadotropin subunit beta variant 2; Chorionic gonadotropin beta subunit 8; Belongs to the glycoprotein hormones subunit beta family | 0.428 |
| ERVFRD-1 | CLEC10A | ENSP00000420174 | ENSP00000254868 | Syncytin-2; This endogenous retroviral envelope protein has retained its original fusogenic properties and participates in trophoblast fusion and the formation of a syncytium during placenta morphogenesis. The interaction with MFSD2A is apparently important for this process | C-type lectin domain family 10 member A; Probable role in regulating adaptive and innate immune responses. Binds in a calcium-dependent manner to terminal galactose and N-acetylgalactosamine units, linked to serine or threonine. These sugar moieties are known as Tn-Ag and are expressed in a variety of carcinoma cells; C-type lectin domain containing | 0.618 |
| ERVFRD-1 | CTBS | ENSP00000420174 | ENSP00000359664 | Syncytin-2; This endogenous retroviral envelope protein has retained its original fusogenic properties and participates in trophoblast fusion and the formation of a syncytium during placenta morphogenesis. The interaction with MFSD2A is apparently important for this process | Di-N-acetylchitobiase; Involved in the degradation of asparagine-linked glycoproteins. Hydrolyze of N-acetyl-beta-D-glucosamine (1-4)N- acetylglucosamine chitobiose core from the reducing end of the bond, it requires prior cleavage by glycosylasparaginase; Chitinases | 0.471 |
| ERVFRD-1 | GCM1 | ENSP00000420174 | ENSP00000259803 | Syncytin-2; This endogenous retroviral envelope protein has retained its original fusogenic properties and participates in trophoblast fusion and the formation of a syncytium during placenta morphogenesis. The interaction with MFSD2A is apparently important for this process | Chorion-specific transcription factor GCMa; Transcription factor involved in the control of expression of placental growth factor (PGF) and other placenta- specific genes. Binds to the trophoblast-specific element 2 (TSE2) of the aromatase gene enhancer. Binds to the SYDE1 promoter. Has a central role in mediating the differentiation of trophoblast cells along both the villous and extravillous pathways in placental development | 0.829 |
| ERVFRD-1 | MFSD2A | ENSP00000420174 | ENSP00000361895 | Syncytin-2; This endogenous retroviral envelope protein has retained its original fusogenic properties and participates in trophoblast fusion and the formation of a syncytium during placenta morphogenesis. The interaction with MFSD2A is apparently important for this process | Sodium-dependent lysophosphatidylcholine symporter 1; Sodium-dependent lysophosphatidylcholine (LPC) symporter, which plays an essential role for blood-brain barrier formation and function (By similarity). Specifically expressed in endothelium of the blood-brain barrier of micro-vessels and transports LPC into the brain (By similarity). Transport of LPC is essential because it constitutes the major mechanism by which docosahexaenoic acid (DHA), an omega-3 fatty acid that is essential for normal brain growth and cognitive function, enters the brain. Transports LPC carrying long-chain fa [...] | 0.757 |
| ERVFRD-1 | SLC1A4 | ENSP00000420174 | ENSP00000234256 | Syncytin-2; This endogenous retroviral envelope protein has retained its original fusogenic properties and participates in trophoblast fusion and the formation of a syncytium during placenta morphogenesis. The interaction with MFSD2A is apparently important for this process | Neutral amino acid transporter A; Transporter for alanine, serine, cysteine, and threonine. Exhibits sodium dependence; Solute carriers | 0.598 |
| ERVFRD-1 | SLC1A5 | ENSP00000420174 | ENSP00000444408 | Syncytin-2; This endogenous retroviral envelope protein has retained its original fusogenic properties and participates in trophoblast fusion and the formation of a syncytium during placenta morphogenesis. The interaction with MFSD2A is apparently important for this process | Neutral amino acid transporter B(0); Sodium-dependent amino acids transporter that has a broad substrate specificity, with a preference for zwitterionic amino acids. It accepts as substrates all neutral amino acids, including glutamine, asparagine, and branched-chain and aromatic amino acids, and excludes methylated, anionic, and cationic amino acids. Through binding of the fusogenic protein syncytin-1/ERVW-1 may mediate trophoblasts syncytialization, the spontaneous fusion of their plasma membranes, an essential process in placental development; Minor histocompatibility antigens | 0.611 |
| ERVFRD-1 | SMIM13 | ENSP00000420174 | ENSP00000451866 | Syncytin-2; This endogenous retroviral envelope protein has retained its original fusogenic properties and participates in trophoblast fusion and the formation of a syncytium during placenta morphogenesis. The interaction with MFSD2A is apparently important for this process | Small integral membrane protein 13 | 0.565 |
| ERVFRD-1 | TCP11 | ENSP00000420174 | ENSP00000308708 | Syncytin-2; This endogenous retroviral envelope protein has retained its original fusogenic properties and participates in trophoblast fusion and the formation of a syncytium during placenta morphogenesis. The interaction with MFSD2A is apparently important for this process | T-complex protein 11 homolog; Plays a role in the process of sperm capacitation and acrosome reactions. Probable receptor for the putative fertilization-promoting peptide (FPP) at the sperm membrane that may modulate the activity of the adenylyl cyclase cAMP pathway; Belongs to the TCP11 family | 0.428 |
| ERVFRD-1 | ZNF117 | ENSP00000420174 | ENSP00000282869 | Syncytin-2; This endogenous retroviral envelope protein has retained its original fusogenic properties and participates in trophoblast fusion and the formation of a syncytium during placenta morphogenesis. The interaction with MFSD2A is apparently important for this process | Zinc finger protein 117; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.550 |
| GCM1 | CGB8 | ENSP00000259803 | ENSP00000403649 | Chorion-specific transcription factor GCMa; Transcription factor involved in the control of expression of placental growth factor (PGF) and other placenta- specific genes. Binds to the trophoblast-specific element 2 (TSE2) of the aromatase gene enhancer. Binds to the SYDE1 promoter. Has a central role in mediating the differentiation of trophoblast cells along both the villous and extravillous pathways in placental development | Choriogonadotropin subunit beta variant 2; Chorionic gonadotropin beta subunit 8; Belongs to the glycoprotein hormones subunit beta family | 0.520 |
| GCM1 | CTBS | ENSP00000259803 | ENSP00000359664 | Chorion-specific transcription factor GCMa; Transcription factor involved in the control of expression of placental growth factor (PGF) and other placenta- specific genes. Binds to the trophoblast-specific element 2 (TSE2) of the aromatase gene enhancer. Binds to the SYDE1 promoter. Has a central role in mediating the differentiation of trophoblast cells along both the villous and extravillous pathways in placental development | Di-N-acetylchitobiase; Involved in the degradation of asparagine-linked glycoproteins. Hydrolyze of N-acetyl-beta-D-glucosamine (1-4)N- acetylglucosamine chitobiose core from the reducing end of the bond, it requires prior cleavage by glycosylasparaginase; Chitinases | 0.569 |
| GCM1 | ERVFRD-1 | ENSP00000259803 | ENSP00000420174 | Chorion-specific transcription factor GCMa; Transcription factor involved in the control of expression of placental growth factor (PGF) and other placenta- specific genes. Binds to the trophoblast-specific element 2 (TSE2) of the aromatase gene enhancer. Binds to the SYDE1 promoter. Has a central role in mediating the differentiation of trophoblast cells along both the villous and extravillous pathways in placental development | Syncytin-2; This endogenous retroviral envelope protein has retained its original fusogenic properties and participates in trophoblast fusion and the formation of a syncytium during placenta morphogenesis. The interaction with MFSD2A is apparently important for this process | 0.829 |
| GCM1 | MFSD2A | ENSP00000259803 | ENSP00000361895 | Chorion-specific transcription factor GCMa; Transcription factor involved in the control of expression of placental growth factor (PGF) and other placenta- specific genes. Binds to the trophoblast-specific element 2 (TSE2) of the aromatase gene enhancer. Binds to the SYDE1 promoter. Has a central role in mediating the differentiation of trophoblast cells along both the villous and extravillous pathways in placental development | Sodium-dependent lysophosphatidylcholine symporter 1; Sodium-dependent lysophosphatidylcholine (LPC) symporter, which plays an essential role for blood-brain barrier formation and function (By similarity). Specifically expressed in endothelium of the blood-brain barrier of micro-vessels and transports LPC into the brain (By similarity). Transport of LPC is essential because it constitutes the major mechanism by which docosahexaenoic acid (DHA), an omega-3 fatty acid that is essential for normal brain growth and cognitive function, enters the brain. Transports LPC carrying long-chain fa [...] | 0.529 |
| GCM1 | SLC1A5 | ENSP00000259803 | ENSP00000444408 | Chorion-specific transcription factor GCMa; Transcription factor involved in the control of expression of placental growth factor (PGF) and other placenta- specific genes. Binds to the trophoblast-specific element 2 (TSE2) of the aromatase gene enhancer. Binds to the SYDE1 promoter. Has a central role in mediating the differentiation of trophoblast cells along both the villous and extravillous pathways in placental development | Neutral amino acid transporter B(0); Sodium-dependent amino acids transporter that has a broad substrate specificity, with a preference for zwitterionic amino acids. It accepts as substrates all neutral amino acids, including glutamine, asparagine, and branched-chain and aromatic amino acids, and excludes methylated, anionic, and cationic amino acids. Through binding of the fusogenic protein syncytin-1/ERVW-1 may mediate trophoblasts syncytialization, the spontaneous fusion of their plasma membranes, an essential process in placental development; Minor histocompatibility antigens | 0.469 |
