PEX5L protein (human) - STRING database

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PEX5L

PEX5-related protein; Accessory subunit of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels, regulating their cell-surface expression and cyclic nucleotide dependence; Belongs to the peroxisomal targeting signal receptor family (626 aa)

Predicted Functional Partners:

PEX7

0.993

PEX14

0.987

PEX13

0.914

SCP2

0.908

PEX3

0.906

PEX12

0.886

PEX16

0.863

PEX6

0.845

PEX10

0.839

PEX5

0.837

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
PEX10	PEX12	ENSP00000288774	ENSP00000482609	Peroxisome biogenesis factor 10; Somewhat implicated in the biogenesis of peroxisomes; Peroxins	Peroxisome assembly protein 12; Required for protein import into peroxisomes; Peroxins	0.999
PEX10	PEX13	ENSP00000288774	ENSP00000295030	Peroxisome biogenesis factor 10; Somewhat implicated in the biogenesis of peroxisomes; Peroxins	Peroxisomal membrane protein PEX13; Component of the peroxisomal translocation machinery with PEX14 and PEX17. Functions as a docking factor for the predominantly cytoplasmic PTS1 receptor (PAS10/PEX5). Involved in the import of PTS1 and PTS2 proteins; Peroxins	0.996
PEX10	PEX14	ENSP00000288774	ENSP00000349016	Peroxisome biogenesis factor 10; Somewhat implicated in the biogenesis of peroxisomes; Peroxins	Peroxisomal membrane protein PEX14; Peroxisome membrane protein that is an essential component of the peroxisomal import machinery. Functions as a docking factor for the predominantly cytoplasmic PTS1 receptor (PEX5). Plays a key role for peroxisome movement through a direct interaction with tubulin; Peroxins	0.992
PEX10	PEX16	ENSP00000288774	ENSP00000241041	Peroxisome biogenesis factor 10; Somewhat implicated in the biogenesis of peroxisomes; Peroxins	Peroxisomal membrane protein PEX16; Required for peroxisome membrane biogenesis. May play a role in early stages of peroxisome assembly. Can recruit other peroxisomal proteins, such as PEX3 and PMP34, to de novo peroxisomes derived from the endoplasmic reticulum (ER). May function as receptor for PEX3; Belongs to the peroxin-16 family	0.917
PEX10	PEX3	ENSP00000288774	ENSP00000356563	Peroxisome biogenesis factor 10; Somewhat implicated in the biogenesis of peroxisomes; Peroxins	Peroxisomal biogenesis factor 3; Involved in peroxisome biosynthesis and integrity. Assembles membrane vesicles before the matrix proteins are translocated. As a docking factor for PEX19, is necessary for the import of peroxisomal membrane proteins in the peroxisomes; Belongs to the peroxin-3 family	0.941
PEX10	PEX5	ENSP00000288774	ENSP00000391601	Peroxisome biogenesis factor 10; Somewhat implicated in the biogenesis of peroxisomes; Peroxins	Peroxisomal targeting signal 1 receptor; Binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import	0.966
PEX10	PEX5L	ENSP00000288774	ENSP00000419975	Peroxisome biogenesis factor 10; Somewhat implicated in the biogenesis of peroxisomes; Peroxins	PEX5-related protein; Accessory subunit of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels, regulating their cell-surface expression and cyclic nucleotide dependence; Belongs to the peroxisomal targeting signal receptor family	0.839
PEX10	PEX6	ENSP00000288774	ENSP00000303511	Peroxisome biogenesis factor 10; Somewhat implicated in the biogenesis of peroxisomes; Peroxins	Peroxisome assembly factor 2; Involved in peroxisome biosynthesis. Required for stability of the PTS1 receptor. Anchored by PEX26 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes	0.995
PEX10	PEX7	ENSP00000288774	ENSP00000315680	Peroxisome biogenesis factor 10; Somewhat implicated in the biogenesis of peroxisomes; Peroxins	Peroxisomal targeting signal 2 receptor; Binds to the N-terminal PTS2-type peroxisomal targeting signal and plays an essential role in peroxisomal protein import; Belongs to the WD repeat peroxin-7 family	0.996
PEX10	SCP2	ENSP00000288774	ENSP00000360569	Peroxisome biogenesis factor 10; Somewhat implicated in the biogenesis of peroxisomes; Peroxins	Non-specific lipid-transfer protein; Mediates in vitro the transfer of all common phospholipids, cholesterol and gangliosides between membranes. May play a role in regulating steroidogenesis	0.931
PEX12	PEX10	ENSP00000482609	ENSP00000288774	Peroxisome assembly protein 12; Required for protein import into peroxisomes; Peroxins	Peroxisome biogenesis factor 10; Somewhat implicated in the biogenesis of peroxisomes; Peroxins	0.999
PEX12	PEX13	ENSP00000482609	ENSP00000295030	Peroxisome assembly protein 12; Required for protein import into peroxisomes; Peroxins	Peroxisomal membrane protein PEX13; Component of the peroxisomal translocation machinery with PEX14 and PEX17. Functions as a docking factor for the predominantly cytoplasmic PTS1 receptor (PAS10/PEX5). Involved in the import of PTS1 and PTS2 proteins; Peroxins	0.998
PEX12	PEX14	ENSP00000482609	ENSP00000349016	Peroxisome assembly protein 12; Required for protein import into peroxisomes; Peroxins	Peroxisomal membrane protein PEX14; Peroxisome membrane protein that is an essential component of the peroxisomal import machinery. Functions as a docking factor for the predominantly cytoplasmic PTS1 receptor (PEX5). Plays a key role for peroxisome movement through a direct interaction with tubulin; Peroxins	0.994
PEX12	PEX16	ENSP00000482609	ENSP00000241041	Peroxisome assembly protein 12; Required for protein import into peroxisomes; Peroxins	Peroxisomal membrane protein PEX16; Required for peroxisome membrane biogenesis. May play a role in early stages of peroxisome assembly. Can recruit other peroxisomal proteins, such as PEX3 and PMP34, to de novo peroxisomes derived from the endoplasmic reticulum (ER). May function as receptor for PEX3; Belongs to the peroxin-16 family	0.904
PEX12	PEX3	ENSP00000482609	ENSP00000356563	Peroxisome assembly protein 12; Required for protein import into peroxisomes; Peroxins	Peroxisomal biogenesis factor 3; Involved in peroxisome biosynthesis and integrity. Assembles membrane vesicles before the matrix proteins are translocated. As a docking factor for PEX19, is necessary for the import of peroxisomal membrane proteins in the peroxisomes; Belongs to the peroxin-3 family	0.985
PEX12	PEX5	ENSP00000482609	ENSP00000391601	Peroxisome assembly protein 12; Required for protein import into peroxisomes; Peroxins	Peroxisomal targeting signal 1 receptor; Binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import	0.988
PEX12	PEX5L	ENSP00000482609	ENSP00000419975	Peroxisome assembly protein 12; Required for protein import into peroxisomes; Peroxins	PEX5-related protein; Accessory subunit of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels, regulating their cell-surface expression and cyclic nucleotide dependence; Belongs to the peroxisomal targeting signal receptor family	0.886
PEX12	PEX6	ENSP00000482609	ENSP00000303511	Peroxisome assembly protein 12; Required for protein import into peroxisomes; Peroxins	Peroxisome assembly factor 2; Involved in peroxisome biosynthesis. Required for stability of the PTS1 receptor. Anchored by PEX26 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes	0.996
PEX12	PEX7	ENSP00000482609	ENSP00000315680	Peroxisome assembly protein 12; Required for protein import into peroxisomes; Peroxins	Peroxisomal targeting signal 2 receptor; Binds to the N-terminal PTS2-type peroxisomal targeting signal and plays an essential role in peroxisomal protein import; Belongs to the WD repeat peroxin-7 family	0.994
PEX12	SCP2	ENSP00000482609	ENSP00000360569	Peroxisome assembly protein 12; Required for protein import into peroxisomes; Peroxins	Non-specific lipid-transfer protein; Mediates in vitro the transfer of all common phospholipids, cholesterol and gangliosides between membranes. May play a role in regulating steroidogenesis	0.931

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