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  • 11.0 [archived version]
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FATE1 FATE1 RNF150 RNF150 RNFT1 RNFT1 RNF186 RNF186 RNF183 RNF183 TMEM129 TMEM129 ZNRF4 ZNRF4 RNFT2 RNFT2 RNF175 RNF175 RNF144B RNF144B RNF144A RNF144A
"RNF183" - Probable E3 ubiquitin-protein ligase RNF183 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Score
RNF183Probable E3 ubiquitin-protein ligase RNF183; May act as a E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. May collaborate with FATE1 to restrain BIK protein levels thus regulating apoptotic signaling; Ring finger proteins (192 aa)    
Predicted Functional Partners:
RNF175
Ring finger protein 175 (328 aa)
           
  0.671
RNF186
Ring finger protein 186 (227 aa)
     
   
  0.659
RNFT2
Ring finger protein, transmembrane 2 (444 aa)
     
   
  0.654
RNFT1
E3 ubiquitin-protein ligase RNFT1; E3 ubiquitin-protein ligase that acts in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway, which targets misfolded proteins that accumulate in the endoplasmic reticulum (ER) for ubiquitination and subsequent proteasome- mediated degradation. Protects cells from ER stress-induced apoptosis; Ring finger proteins (435 aa)
     
   
  0.640
RNF150
Ring finger protein 150 (438 aa)
     
   
  0.630
FATE1
Fetal and adult testis-expressed transcript protein; Involved in the regulation of endoplasmic reticulum (ER)-mitochondria coupling. Negatively regulates the ER- mitochondria distance and Ca(2+) transfer from ER to mitochondria possibly implicating it in the regulation of apoptosis. May collaborate with RNF183 to restrain BIK protein levels thus regulating apoptotic signaling (183 aa)
       
 
  0.626
RNF144A
E3 ubiquitin-protein ligase RNF144A; E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates the ubiquitination and degradation of the DNA damage kinase PRKDC (292 aa)
       
 
  0.614
ZNRF4
E3 ubiquitin-protein ligase ZNRF4; E3 ubiquitin-protein ligase which specifically induces ubiquitination and proteasomal degradation of CANX within the endoplasmic reticulum. Could have a role in spermatogenesis (By similarity); Ring finger proteins (429 aa)
           
  0.614
RNF144B
E3 ubiquitin-protein ligase RNF144B; E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates such as LCMT2, thereby promoting their degradation. Induces apoptosis via a p53/TP53-dependent but caspase-independent mechanism. However, its overexpression also produces a decrease of the ubiquitin-dependent stability of BAX, a pro-apoptotic protein, ultimately leading to protection of cell death; But, it is not an anti-apoptotic protein per se (303 aa)
       
 
  0.602
TMEM129
E3 ubiquitin-protein ligase TM129; E3 ubiquitin-protein ligase involved in ER-associated protein degradation, preferentially associates with the E2 enzyme UBE2J2. Exploited by viral US11 proteins to mediate HLA class I proteins degradation (362 aa)
           
  0.594
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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