node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C1orf52 | CTSD | ENSP00000419417 | ENSP00000236671 | UPF0690 protein C1orf52; Chromosome 1 open reading frame 52; Belongs to the UPF0690 family | Cathepsin D; Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation. Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease; Cathepsins | 0.573 |
C1orf52 | DDAH1 | ENSP00000419417 | ENSP00000284031 | UPF0690 protein C1orf52; Chromosome 1 open reading frame 52; Belongs to the UPF0690 family | N(G),N(G)-dimethylarginine dimethylaminohydrolase 1; Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation | 0.540 |
C1orf52 | DIEXF | ENSP00000419417 | ENSP00000419005 | UPF0690 protein C1orf52; Chromosome 1 open reading frame 52; Belongs to the UPF0690 family | Digestive organ expansion factor homolog; Regulates the p53 pathway to control the expansion growth of digestive organs | 0.440 |
C1orf52 | NDFIP2 | ENSP00000419417 | ENSP00000480798 | UPF0690 protein C1orf52; Chromosome 1 open reading frame 52; Belongs to the UPF0690 family | NEDD4 family-interacting protein 2; Activates HECT domain-containing E3 ubiquitin-protein ligases, including ITCH, NEDD4, NEDD4L, SMURF2, WWP1 and WWP2, and consequently modulates the stability of their targets. As a result, may control many cellular processes. Recruits ITCH, NEDD4 and SMURF2 to endosomal membranes. Negatively regulates KCNH2 potassium channel activity by decreasing its cell-surface expression and interfering with channel maturation through recruitment of NEDD4L to the Golgi apparatus and multivesicular body where it mediates KCNH2 degradation. May modulate EGFR signal [...] | 0.454 |
C1orf52 | RBM33 | ENSP00000419417 | ENSP00000384160 | UPF0690 protein C1orf52; Chromosome 1 open reading frame 52; Belongs to the UPF0690 family | RNA-binding protein 33; RNA binding motif containing | 0.530 |
C1orf52 | RPL34 | ENSP00000419417 | ENSP00000378163 | UPF0690 protein C1orf52; Chromosome 1 open reading frame 52; Belongs to the UPF0690 family | 60S ribosomal protein L34; Component of the large ribosomal subunit | 0.453 |
C1orf52 | SYDE2 | ENSP00000419417 | ENSP00000340594 | UPF0690 protein C1orf52; Chromosome 1 open reading frame 52; Belongs to the UPF0690 family | Rho GTPase-activating protein SYDE2; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state; C2 domain containing | 0.534 |
C1orf52 | UBTD1 | ENSP00000419417 | ENSP00000359698 | UPF0690 protein C1orf52; Chromosome 1 open reading frame 52; Belongs to the UPF0690 family | Ubiquitin domain-containing protein 1; May be involved in the regulation of cellular senescence through a positive feedback loop with TP53. Is a TP53 downstream target gene that increases the stability of TP53 protein by promoting the ubiquitination and degradation of MDM2 | 0.704 |
C1orf52 | UBTD2 | ENSP00000419417 | ENSP00000377381 | UPF0690 protein C1orf52; Chromosome 1 open reading frame 52; Belongs to the UPF0690 family | Ubiquitin domain containing 2 | 0.491 |
C1orf52 | ZNHIT6 | ENSP00000419417 | ENSP00000359606 | UPF0690 protein C1orf52; Chromosome 1 open reading frame 52; Belongs to the UPF0690 family | Box C/D snoRNA protein 1; Required for box C/D snoRNAs accumulation involved in snoRNA processing, snoRNA transport to the nucleolus and ribosome biogenesis; Belongs to the BCD1 family | 0.713 |
CTSD | C1orf52 | ENSP00000236671 | ENSP00000419417 | Cathepsin D; Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation. Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease; Cathepsins | UPF0690 protein C1orf52; Chromosome 1 open reading frame 52; Belongs to the UPF0690 family | 0.573 |
DDAH1 | C1orf52 | ENSP00000284031 | ENSP00000419417 | N(G),N(G)-dimethylarginine dimethylaminohydrolase 1; Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation | UPF0690 protein C1orf52; Chromosome 1 open reading frame 52; Belongs to the UPF0690 family | 0.540 |
DDAH1 | ZNHIT6 | ENSP00000284031 | ENSP00000359606 | N(G),N(G)-dimethylarginine dimethylaminohydrolase 1; Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation | Box C/D snoRNA protein 1; Required for box C/D snoRNAs accumulation involved in snoRNA processing, snoRNA transport to the nucleolus and ribosome biogenesis; Belongs to the BCD1 family | 0.411 |
DIEXF | C1orf52 | ENSP00000419005 | ENSP00000419417 | Digestive organ expansion factor homolog; Regulates the p53 pathway to control the expansion growth of digestive organs | UPF0690 protein C1orf52; Chromosome 1 open reading frame 52; Belongs to the UPF0690 family | 0.440 |
NDFIP2 | C1orf52 | ENSP00000480798 | ENSP00000419417 | NEDD4 family-interacting protein 2; Activates HECT domain-containing E3 ubiquitin-protein ligases, including ITCH, NEDD4, NEDD4L, SMURF2, WWP1 and WWP2, and consequently modulates the stability of their targets. As a result, may control many cellular processes. Recruits ITCH, NEDD4 and SMURF2 to endosomal membranes. Negatively regulates KCNH2 potassium channel activity by decreasing its cell-surface expression and interfering with channel maturation through recruitment of NEDD4L to the Golgi apparatus and multivesicular body where it mediates KCNH2 degradation. May modulate EGFR signal [...] | UPF0690 protein C1orf52; Chromosome 1 open reading frame 52; Belongs to the UPF0690 family | 0.454 |
RBM33 | C1orf52 | ENSP00000384160 | ENSP00000419417 | RNA-binding protein 33; RNA binding motif containing | UPF0690 protein C1orf52; Chromosome 1 open reading frame 52; Belongs to the UPF0690 family | 0.530 |
RPL34 | C1orf52 | ENSP00000378163 | ENSP00000419417 | 60S ribosomal protein L34; Component of the large ribosomal subunit | UPF0690 protein C1orf52; Chromosome 1 open reading frame 52; Belongs to the UPF0690 family | 0.453 |
SYDE2 | C1orf52 | ENSP00000340594 | ENSP00000419417 | Rho GTPase-activating protein SYDE2; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state; C2 domain containing | UPF0690 protein C1orf52; Chromosome 1 open reading frame 52; Belongs to the UPF0690 family | 0.534 |
UBTD1 | C1orf52 | ENSP00000359698 | ENSP00000419417 | Ubiquitin domain-containing protein 1; May be involved in the regulation of cellular senescence through a positive feedback loop with TP53. Is a TP53 downstream target gene that increases the stability of TP53 protein by promoting the ubiquitination and degradation of MDM2 | UPF0690 protein C1orf52; Chromosome 1 open reading frame 52; Belongs to the UPF0690 family | 0.704 |
UBTD2 | C1orf52 | ENSP00000377381 | ENSP00000419417 | Ubiquitin domain containing 2 | UPF0690 protein C1orf52; Chromosome 1 open reading frame 52; Belongs to the UPF0690 family | 0.491 |