node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BEST3 | BEST4 | ENSP00000332413 | ENSP00000361281 | Bestrophin-3; Forms calcium-sensitive chloride channels. Permeable to bicarbonate; Belongs to the bestrophin family | Bestrophin-4; Forms calcium-sensitive chloride channels. Permeable to bicarbonate; Bestrophins | 0.562 |
BEST3 | CLCN1 | ENSP00000332413 | ENSP00000339867 | Bestrophin-3; Forms calcium-sensitive chloride channels. Permeable to bicarbonate; Belongs to the bestrophin family | Chloride channel protein 1; Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport; Belongs to the chloride channel (TC 2.A.49) family. ClC-1/CLCN1 subfamily | 0.721 |
BEST3 | CLCN2 | ENSP00000332413 | ENSP00000265593 | Bestrophin-3; Forms calcium-sensitive chloride channels. Permeable to bicarbonate; Belongs to the bestrophin family | Chloride channel protein 2; Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport; Belongs to the chloride channel (TC 2.A.49) family. ClC-2/CLCN2 subfamily | 0.689 |
BEST3 | CLIC3 | ENSP00000332413 | ENSP00000419378 | Bestrophin-3; Forms calcium-sensitive chloride channels. Permeable to bicarbonate; Belongs to the bestrophin family | Chloride intracellular channel protein 3; Can insert into membranes and form chloride ion channels. May participate in cellular growth control; Belongs to the chloride channel CLIC family | 0.652 |
BEST3 | GABRR2 | ENSP00000332413 | ENSP00000386029 | Bestrophin-3; Forms calcium-sensitive chloride channels. Permeable to bicarbonate; Belongs to the bestrophin family | Gamma-aminobutyric acid receptor subunit rho-2; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Rho-2 GABA receptor could play a role in retinal neurotransmission; Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRR2 sub-subfamily | 0.641 |
BEST3 | GLRB | ENSP00000332413 | ENSP00000264428 | Bestrophin-3; Forms calcium-sensitive chloride channels. Permeable to bicarbonate; Belongs to the bestrophin family | Glycine receptor subunit beta; Glycine receptors are ligand-gated chloride channels. GLRB does not form ligand-gated ion channels by itself, but is part of heteromeric ligand-gated chloride channels. Channel opening is triggered by extracellular glycine. Heteropentameric channels composed of GLRB and GLRA1 are activated by lower glycine levels than homopentameric GLRA1. Plays an important role in the down-regulation of neuronal excitability. Contributes to the generation of inhibitory postsynaptic currents | 0.610 |
BEST4 | BEST3 | ENSP00000361281 | ENSP00000332413 | Bestrophin-4; Forms calcium-sensitive chloride channels. Permeable to bicarbonate; Bestrophins | Bestrophin-3; Forms calcium-sensitive chloride channels. Permeable to bicarbonate; Belongs to the bestrophin family | 0.562 |
BEST4 | CLCN1 | ENSP00000361281 | ENSP00000339867 | Bestrophin-4; Forms calcium-sensitive chloride channels. Permeable to bicarbonate; Bestrophins | Chloride channel protein 1; Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport; Belongs to the chloride channel (TC 2.A.49) family. ClC-1/CLCN1 subfamily | 0.713 |
BEST4 | CLCN2 | ENSP00000361281 | ENSP00000265593 | Bestrophin-4; Forms calcium-sensitive chloride channels. Permeable to bicarbonate; Bestrophins | Chloride channel protein 2; Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport; Belongs to the chloride channel (TC 2.A.49) family. ClC-2/CLCN2 subfamily | 0.682 |
BEST4 | CLIC3 | ENSP00000361281 | ENSP00000419378 | Bestrophin-4; Forms calcium-sensitive chloride channels. Permeable to bicarbonate; Bestrophins | Chloride intracellular channel protein 3; Can insert into membranes and form chloride ion channels. May participate in cellular growth control; Belongs to the chloride channel CLIC family | 0.631 |
BEST4 | GABRR2 | ENSP00000361281 | ENSP00000386029 | Bestrophin-4; Forms calcium-sensitive chloride channels. Permeable to bicarbonate; Bestrophins | Gamma-aminobutyric acid receptor subunit rho-2; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Rho-2 GABA receptor could play a role in retinal neurotransmission; Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRR2 sub-subfamily | 0.544 |
BEST4 | GLRB | ENSP00000361281 | ENSP00000264428 | Bestrophin-4; Forms calcium-sensitive chloride channels. Permeable to bicarbonate; Bestrophins | Glycine receptor subunit beta; Glycine receptors are ligand-gated chloride channels. GLRB does not form ligand-gated ion channels by itself, but is part of heteromeric ligand-gated chloride channels. Channel opening is triggered by extracellular glycine. Heteropentameric channels composed of GLRB and GLRA1 are activated by lower glycine levels than homopentameric GLRA1. Plays an important role in the down-regulation of neuronal excitability. Contributes to the generation of inhibitory postsynaptic currents | 0.591 |
CLCN1 | BEST3 | ENSP00000339867 | ENSP00000332413 | Chloride channel protein 1; Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport; Belongs to the chloride channel (TC 2.A.49) family. ClC-1/CLCN1 subfamily | Bestrophin-3; Forms calcium-sensitive chloride channels. Permeable to bicarbonate; Belongs to the bestrophin family | 0.721 |
CLCN1 | BEST4 | ENSP00000339867 | ENSP00000361281 | Chloride channel protein 1; Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport; Belongs to the chloride channel (TC 2.A.49) family. ClC-1/CLCN1 subfamily | Bestrophin-4; Forms calcium-sensitive chloride channels. Permeable to bicarbonate; Bestrophins | 0.713 |
CLCN1 | CLCN2 | ENSP00000339867 | ENSP00000265593 | Chloride channel protein 1; Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport; Belongs to the chloride channel (TC 2.A.49) family. ClC-1/CLCN1 subfamily | Chloride channel protein 2; Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport; Belongs to the chloride channel (TC 2.A.49) family. ClC-2/CLCN2 subfamily | 0.554 |
CLCN1 | CLIC3 | ENSP00000339867 | ENSP00000419378 | Chloride channel protein 1; Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport; Belongs to the chloride channel (TC 2.A.49) family. ClC-1/CLCN1 subfamily | Chloride intracellular channel protein 3; Can insert into membranes and form chloride ion channels. May participate in cellular growth control; Belongs to the chloride channel CLIC family | 0.623 |
CLCN1 | GABRR2 | ENSP00000339867 | ENSP00000386029 | Chloride channel protein 1; Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport; Belongs to the chloride channel (TC 2.A.49) family. ClC-1/CLCN1 subfamily | Gamma-aminobutyric acid receptor subunit rho-2; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Rho-2 GABA receptor could play a role in retinal neurotransmission; Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRR2 sub-subfamily | 0.596 |
CLCN1 | GLRB | ENSP00000339867 | ENSP00000264428 | Chloride channel protein 1; Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport; Belongs to the chloride channel (TC 2.A.49) family. ClC-1/CLCN1 subfamily | Glycine receptor subunit beta; Glycine receptors are ligand-gated chloride channels. GLRB does not form ligand-gated ion channels by itself, but is part of heteromeric ligand-gated chloride channels. Channel opening is triggered by extracellular glycine. Heteropentameric channels composed of GLRB and GLRA1 are activated by lower glycine levels than homopentameric GLRA1. Plays an important role in the down-regulation of neuronal excitability. Contributes to the generation of inhibitory postsynaptic currents | 0.602 |
CLCN2 | BEST3 | ENSP00000265593 | ENSP00000332413 | Chloride channel protein 2; Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport; Belongs to the chloride channel (TC 2.A.49) family. ClC-2/CLCN2 subfamily | Bestrophin-3; Forms calcium-sensitive chloride channels. Permeable to bicarbonate; Belongs to the bestrophin family | 0.689 |
CLCN2 | BEST4 | ENSP00000265593 | ENSP00000361281 | Chloride channel protein 2; Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport; Belongs to the chloride channel (TC 2.A.49) family. ClC-2/CLCN2 subfamily | Bestrophin-4; Forms calcium-sensitive chloride channels. Permeable to bicarbonate; Bestrophins | 0.682 |