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  • 11.0 [archived version]
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TCAIM TCAIM MAPK15 MAPK15 ENPP5 ENPP5 CLIC3 CLIC3 BEST3 BEST3 GABRR2 GABRR2 NIPAL3 NIPAL3 CLCN2 CLCN2 GLRB GLRB CLCN1 CLCN1 BEST4 BEST4
"CLIC3" - Chloride intracellular channel protein 3 in Homo sapiens
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second shell of interactors
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Known Interactions
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experimentally determined
Predicted Interactions
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gene co-occurrence
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textmining
co-expression
protein homology
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CLIC3Chloride intracellular channel protein 3; Can insert into membranes and form chloride ion channels. May participate in cellular growth control; Belongs to the chloride channel CLIC family (236 aa)    
Predicted Functional Partners:
MAPK15
Mitogen-activated protein kinase 15; In vitro, phosphorylates MBP; Mitogen-activated protein kinases (544 aa)
     
 
  0.939
TCAIM
T-cell activation inhibitor, mitochondrial; May regulate T-cell apoptosis (496 aa)
           
  0.680
GLRB
Glycine receptor subunit beta; Glycine receptors are ligand-gated chloride channels. GLRB does not form ligand-gated ion channels by itself, but is part of heteromeric ligand-gated chloride channels. Channel opening is triggered by extracellular glycine. Heteropentameric channels composed of GLRB and GLRA1 are activated by lower glycine levels than homopentameric GLRA1. Plays an important role in the down-regulation of neuronal excitability. Contributes to the generation of inhibitory postsynaptic currents (497 aa)
         
  0.677
BEST3
Bestrophin-3; Forms calcium-sensitive chloride channels. Permeable to bicarbonate; Belongs to the bestrophin family (668 aa)
         
  0.652
ENPP5
Ectonucleotide pyrophosphatase/phosphodiesterase family member 5; May play a role in neuronal cell communication. Lacks nucleotide pyrophosphatase and lysopholipase D activity (By similarity); Belongs to the nucleotide pyrophosphatase/phosphodiesterase family (477 aa)
           
  0.636
GABRR2
Gamma-aminobutyric acid receptor subunit rho-2; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Rho-2 GABA receptor could play a role in retinal neurotransmission; Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRR2 sub-subfamily (465 aa)
         
  0.631
BEST4
Bestrophin-4; Forms calcium-sensitive chloride channels. Permeable to bicarbonate; Bestrophins (473 aa)
         
  0.631
CLCN1
Chloride channel protein 1; Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport; Belongs to the chloride channel (TC 2.A.49) family. ClC-1/CLCN1 subfamily (988 aa)
         
  0.623
NIPAL3
NIPA-like protein 3; NIPA like domain containing 3 (406 aa)
           
  0.621
CLCN2
Chloride channel protein 2; Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport; Belongs to the chloride channel (TC 2.A.49) family. ClC-2/CLCN2 subfamily (898 aa)
         
  0.617
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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