• Version:
  • 11.0 [archived version]
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MALSU1 MALSU1 MRPL4 MRPL4 MRPL41 MRPL41 MRPS30 MRPS30 MRPL14 MRPL14 MRPL19 MRPL19 MRPL32 MRPL32 MRPL28 MRPL28 MRPL37 MRPL37 MRPL35 MRPL35 ICT1 ICT1
"MALSU1" - Mitochondrial assembly of ribosomal large subunit protein 1 in Homo sapiens
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
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MALSU1Mitochondrial assembly of ribosomal large subunit protein 1; May function as a ribosomal silencing factor. Addition to isolated mitochondrial ribosomal subunits partially inhibits translation. Interacts with mitochondrial ribosomal protein L14 (MRPL14), probably blocking formation of intersubunit bridge B8, preventing association of the 28S and 39S ribosomal subunits and the formation of functional ribosomes, thus repressing translation. May also participate in the assembly and/or regulation of the stability of the large subunit of the mitochondrial ribosome; Belongs to the Iojap/RsfS family (234 aa)    
Predicted Functional Partners:
ICT1
Peptidyl-tRNA hydrolase ICT1, mitochondrial; Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes (206 aa)
   
 
  0.960
MRPL35
Mitochondrial ribosomal protein L35 (188 aa)
     
      0.956
MRPL32
Mitochondrial ribosomal protein L32; Belongs to the bacterial ribosomal protein bL32 family (188 aa)
   
 
  0.954
MRPL19
Mitochondrial ribosomal protein L19; Belongs to the bacterial ribosomal protein bL19 family (292 aa)
   
 
  0.950
MRPL28
Mitochondrial ribosomal protein L28 (256 aa)
     
      0.950
MRPL4
Mitochondrial ribosomal protein L4; Belongs to the universal ribosomal protein uL4 family (311 aa)
     
      0.950
MRPL37
Mitochondrial ribosomal protein L37; Belongs to the mitochondrion-specific ribosomal protein mL37 family (423 aa)
     
 
  0.946
MRPL14
39S ribosomal protein L14, mitochondrial; Forms part of 2 intersubunit bridges in the assembled ribosome. Upon binding to MALSU1 intersubunit bridge formation is blocked, preventing ribosome formation and repressing translation (Probable); Mitochondrial ribosomal proteins (145 aa)
     
 
  0.944
MRPS30
Mitochondrial ribosomal protein S30 (439 aa)
     
 
  0.939
MRPL41
39S ribosomal protein L41, mitochondrial; Component of the mitochondrial ribosome large subunit. Also involved in apoptosis and cell cycle. Enhances p53/TP53 stability, thereby contributing to p53/TP53-induced apoptosis in response to growth-inhibitory condition. Enhances p53/TP53 translocation to the mitochondria. Has the ability to arrest the cell cycle at the G1 phase, possibly by stabilizing the CDKN1A and CDKN1B (p27Kip1) proteins (137 aa)
     
 
  0.938
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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