node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACTL6B | ONECUT2 | ENSP00000160382 | ENSP00000419185 | Actin-like protein 6B; Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Belongs to the neuron-specific chromatin remodeling complex (nBAF complex), as such plays a role in remodeling mononucleosomes in an ATP-dependent fashion, and is required for postmitotic neural development and dendritic outgrowth. [...] | One cut domain family member 2; Transcriptional activator. Activates the transcription of a number of liver genes such as HNF3B; CUT class homeoboxes and pseudogenes | 0.479 |
ACTL6B | PHF10 | ENSP00000160382 | ENSP00000341805 | Actin-like protein 6B; Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Belongs to the neuron-specific chromatin remodeling complex (nBAF complex), as such plays a role in remodeling mononucleosomes in an ATP-dependent fashion, and is required for postmitotic neural development and dendritic outgrowth. [...] | PHD finger protein 10; Involved in transcription activity regulation by chromatin remodeling. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and is required for the proliferation of neural progenitors. During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. [...] | 0.965 |
ACTL6B | SYTL4 | ENSP00000160382 | ENSP00000362080 | Actin-like protein 6B; Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Belongs to the neuron-specific chromatin remodeling complex (nBAF complex), as such plays a role in remodeling mononucleosomes in an ATP-dependent fashion, and is required for postmitotic neural development and dendritic outgrowth. [...] | Synaptotagmin-like protein 4; Modulates exocytosis of dense-core granules and secretion of hormones in the pancreas and the pituitary. Interacts with vesicles containing negatively charged phospholipids in a Ca(2+)-independent manner (By similarity); Synaptotagmin like tandem C2 proteins | 0.499 |
CTSS | ONECUT2 | ENSP00000357981 | ENSP00000419185 | Cathepsin S; Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond- specificity of this proteinase is in part similar to the specificities of cathepsin L and cathepsin N; Cathepsins | One cut domain family member 2; Transcriptional activator. Activates the transcription of a number of liver genes such as HNF3B; CUT class homeoboxes and pseudogenes | 0.481 |
FOXA2 | ONECUT2 | ENSP00000400341 | ENSP00000419185 | Hepatocyte nuclear factor 3-beta; Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a ’pioneer’ factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5’-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3’ (By similarity). In embryonic development is required for notochord formation. Invo [...] | One cut domain family member 2; Transcriptional activator. Activates the transcription of a number of liver genes such as HNF3B; CUT class homeoboxes and pseudogenes | 0.498 |
FOXA2 | PROX1 | ENSP00000400341 | ENSP00000355925 | Hepatocyte nuclear factor 3-beta; Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a ’pioneer’ factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5’-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3’ (By similarity). In embryonic development is required for notochord formation. Invo [...] | Prospero homeobox protein 1; Transcription factor involved in developmental processes such as cell fate determination, gene transcriptional regulation and progenitor cell regulation in a number of organs. Plays a critical role in embryonic development and functions as a key regulatory protein in neurogenesis and the development of the heart, eye lens, liver, pancreas and the lymphatic system. Involved in the regulation of the circadian rhythm. Represses- transcription of the retinoid-related orphan receptor RORG, transcriptional activator activity of RORA and RORG and the expression of [...] | 0.450 |
MITF | ONECUT2 | ENSP00000295600 | ENSP00000419185 | Microphthalmia-associated transcription factor; Transcription factor that regulates the expression of genes with essential roles in cell differentiation, proliferation and survival. Binds to M-boxes (5’-TCATGTG-3’) and symmetrical DNA sequences (E-boxes) (5’-CACGTG-3’) found in the promoters of target genes, such as BCL2 and tyrosinase (TYR). Plays an important role in melanocyte development by regulating the expression of tyrosinase (TYR) and tyrosinase-related protein 1 (TYRP1). Plays a critical role in the differentiation of various cell types, such as neural crest-derived melanocyt [...] | One cut domain family member 2; Transcriptional activator. Activates the transcription of a number of liver genes such as HNF3B; CUT class homeoboxes and pseudogenes | 0.540 |
MITF | RAB27A | ENSP00000295600 | ENSP00000379601 | Microphthalmia-associated transcription factor; Transcription factor that regulates the expression of genes with essential roles in cell differentiation, proliferation and survival. Binds to M-boxes (5’-TCATGTG-3’) and symmetrical DNA sequences (E-boxes) (5’-CACGTG-3’) found in the promoters of target genes, such as BCL2 and tyrosinase (TYR). Plays an important role in melanocyte development by regulating the expression of tyrosinase (TYR) and tyrosinase-related protein 1 (TYRP1). Plays a critical role in the differentiation of various cell types, such as neural crest-derived melanocyt [...] | Ras-related protein Rab-27A; Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse; RAB, member RAS oncogene GTPases | 0.686 |
MTPN | ONECUT2 | ENSP00000376800 | ENSP00000419185 | Myotrophin; Promotes dimerization of NF-kappa-B subunits and regulates NF-kappa-B transcription factor activity (By similarity). Plays a role in the regulation of the growth of actin filaments. Inhibits the activity of the F-actin-capping protein complex formed by the CAPZA1 and CAPZB heterodimer. Promotes growth of cardiomyocytes, but not cardiomyocyte proliferation. Promotes cardiac muscle hypertrophy; Belongs to the myotrophin family | One cut domain family member 2; Transcriptional activator. Activates the transcription of a number of liver genes such as HNF3B; CUT class homeoboxes and pseudogenes | 0.624 |
MTPN | SYTL4 | ENSP00000376800 | ENSP00000362080 | Myotrophin; Promotes dimerization of NF-kappa-B subunits and regulates NF-kappa-B transcription factor activity (By similarity). Plays a role in the regulation of the growth of actin filaments. Inhibits the activity of the F-actin-capping protein complex formed by the CAPZA1 and CAPZB heterodimer. Promotes growth of cardiomyocytes, but not cardiomyocyte proliferation. Promotes cardiac muscle hypertrophy; Belongs to the myotrophin family | Synaptotagmin-like protein 4; Modulates exocytosis of dense-core granules and secretion of hormones in the pancreas and the pituitary. Interacts with vesicles containing negatively charged phospholipids in a Ca(2+)-independent manner (By similarity); Synaptotagmin like tandem C2 proteins | 0.535 |
ONECUT2 | ACTL6B | ENSP00000419185 | ENSP00000160382 | One cut domain family member 2; Transcriptional activator. Activates the transcription of a number of liver genes such as HNF3B; CUT class homeoboxes and pseudogenes | Actin-like protein 6B; Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Belongs to the neuron-specific chromatin remodeling complex (nBAF complex), as such plays a role in remodeling mononucleosomes in an ATP-dependent fashion, and is required for postmitotic neural development and dendritic outgrowth. [...] | 0.479 |
ONECUT2 | CTSS | ENSP00000419185 | ENSP00000357981 | One cut domain family member 2; Transcriptional activator. Activates the transcription of a number of liver genes such as HNF3B; CUT class homeoboxes and pseudogenes | Cathepsin S; Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond- specificity of this proteinase is in part similar to the specificities of cathepsin L and cathepsin N; Cathepsins | 0.481 |
ONECUT2 | FOXA2 | ENSP00000419185 | ENSP00000400341 | One cut domain family member 2; Transcriptional activator. Activates the transcription of a number of liver genes such as HNF3B; CUT class homeoboxes and pseudogenes | Hepatocyte nuclear factor 3-beta; Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a ’pioneer’ factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5’-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3’ (By similarity). In embryonic development is required for notochord formation. Invo [...] | 0.498 |
ONECUT2 | MITF | ENSP00000419185 | ENSP00000295600 | One cut domain family member 2; Transcriptional activator. Activates the transcription of a number of liver genes such as HNF3B; CUT class homeoboxes and pseudogenes | Microphthalmia-associated transcription factor; Transcription factor that regulates the expression of genes with essential roles in cell differentiation, proliferation and survival. Binds to M-boxes (5’-TCATGTG-3’) and symmetrical DNA sequences (E-boxes) (5’-CACGTG-3’) found in the promoters of target genes, such as BCL2 and tyrosinase (TYR). Plays an important role in melanocyte development by regulating the expression of tyrosinase (TYR) and tyrosinase-related protein 1 (TYRP1). Plays a critical role in the differentiation of various cell types, such as neural crest-derived melanocyt [...] | 0.540 |
ONECUT2 | MTPN | ENSP00000419185 | ENSP00000376800 | One cut domain family member 2; Transcriptional activator. Activates the transcription of a number of liver genes such as HNF3B; CUT class homeoboxes and pseudogenes | Myotrophin; Promotes dimerization of NF-kappa-B subunits and regulates NF-kappa-B transcription factor activity (By similarity). Plays a role in the regulation of the growth of actin filaments. Inhibits the activity of the F-actin-capping protein complex formed by the CAPZA1 and CAPZB heterodimer. Promotes growth of cardiomyocytes, but not cardiomyocyte proliferation. Promotes cardiac muscle hypertrophy; Belongs to the myotrophin family | 0.624 |
ONECUT2 | PHF10 | ENSP00000419185 | ENSP00000341805 | One cut domain family member 2; Transcriptional activator. Activates the transcription of a number of liver genes such as HNF3B; CUT class homeoboxes and pseudogenes | PHD finger protein 10; Involved in transcription activity regulation by chromatin remodeling. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and is required for the proliferation of neural progenitors. During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. [...] | 0.551 |
ONECUT2 | PROX1 | ENSP00000419185 | ENSP00000355925 | One cut domain family member 2; Transcriptional activator. Activates the transcription of a number of liver genes such as HNF3B; CUT class homeoboxes and pseudogenes | Prospero homeobox protein 1; Transcription factor involved in developmental processes such as cell fate determination, gene transcriptional regulation and progenitor cell regulation in a number of organs. Plays a critical role in embryonic development and functions as a key regulatory protein in neurogenesis and the development of the heart, eye lens, liver, pancreas and the lymphatic system. Involved in the regulation of the circadian rhythm. Represses- transcription of the retinoid-related orphan receptor RORG, transcriptional activator activity of RORA and RORG and the expression of [...] | 0.512 |
ONECUT2 | RAB27A | ENSP00000419185 | ENSP00000379601 | One cut domain family member 2; Transcriptional activator. Activates the transcription of a number of liver genes such as HNF3B; CUT class homeoboxes and pseudogenes | Ras-related protein Rab-27A; Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse; RAB, member RAS oncogene GTPases | 0.630 |
ONECUT2 | SYTL4 | ENSP00000419185 | ENSP00000362080 | One cut domain family member 2; Transcriptional activator. Activates the transcription of a number of liver genes such as HNF3B; CUT class homeoboxes and pseudogenes | Synaptotagmin-like protein 4; Modulates exocytosis of dense-core granules and secretion of hormones in the pancreas and the pituitary. Interacts with vesicles containing negatively charged phospholipids in a Ca(2+)-independent manner (By similarity); Synaptotagmin like tandem C2 proteins | 0.959 |
ONECUT2 | TCF15 | ENSP00000419185 | ENSP00000246080 | One cut domain family member 2; Transcriptional activator. Activates the transcription of a number of liver genes such as HNF3B; CUT class homeoboxes and pseudogenes | Transcription factor 15; May function as an early transcriptional regulator, involved in the patterning of the mesoderm and in lineage determination of cell types derived from the mesoderm; Basic helix-loop-helix proteins | 0.510 |