| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ACADSB | C10orf88 | ENSP00000357873 | ENSP00000419126 | Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial; Has greatest activity toward short branched chain acyl- CoA derivative such as (s)-2-methylbutyryl-CoA, isobutyryl-CoA, and 2-methylhexanoyl-CoA as well as toward short straight chain acyl-CoAs such as butyryl-CoA and hexanoyl-CoA. Can use valproyl- CoA as substrate and may play a role in controlling the metabolic flux of valproic acid in the development of toxicity of this agent | Uncharacterized protein C10orf88; Chromosome 10 open reading frame 88 | 0.572 |
| ADAM12 | C10orf88 | ENSP00000357668 | ENSP00000419126 | Disintegrin and metalloproteinase domain-containing protein 12; Involved in skeletal muscle regeneration, specifically at the onset of cell fusion. Also involved in macrophage-derived giant cells (MGC) and osteoclast formation from mononuclear precursors (By similarity); ADAM metallopeptidase domain containing | Uncharacterized protein C10orf88; Chromosome 10 open reading frame 88 | 0.488 |
| C10orf88 | ACADSB | ENSP00000419126 | ENSP00000357873 | Uncharacterized protein C10orf88; Chromosome 10 open reading frame 88 | Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial; Has greatest activity toward short branched chain acyl- CoA derivative such as (s)-2-methylbutyryl-CoA, isobutyryl-CoA, and 2-methylhexanoyl-CoA as well as toward short straight chain acyl-CoAs such as butyryl-CoA and hexanoyl-CoA. Can use valproyl- CoA as substrate and may play a role in controlling the metabolic flux of valproic acid in the development of toxicity of this agent | 0.572 |
| C10orf88 | ADAM12 | ENSP00000419126 | ENSP00000357668 | Uncharacterized protein C10orf88; Chromosome 10 open reading frame 88 | Disintegrin and metalloproteinase domain-containing protein 12; Involved in skeletal muscle regeneration, specifically at the onset of cell fusion. Also involved in macrophage-derived giant cells (MGC) and osteoclast formation from mononuclear precursors (By similarity); ADAM metallopeptidase domain containing | 0.488 |
| C10orf88 | CACUL1 | ENSP00000419126 | ENSP00000358147 | Uncharacterized protein C10orf88; Chromosome 10 open reading frame 88 | CDK2-associated and cullin domain-containing protein 1; Cell cycle associated protein capable of promoting cell proliferation through the activation of CDK2 at the G1/S phase transition | 0.576 |
| C10orf88 | CYP24A1 | ENSP00000419126 | ENSP00000216862 | Uncharacterized protein C10orf88; Chromosome 10 open reading frame 88 | 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial; Has a role in maintaining calcium homeostasis. Catalyzes the NADPH-dependent 24-hydroxylation of calcidiol (25- hydroxyvitamin D(3)) and calcitriol (1-alpha,25-dihydroxyvitamin D(3)). The enzyme can perform up to 6 rounds of hydroxylation of calcitriol leading to calcitroic acid. It also shows 23- hydroxylating activity leading to 1-alpha,25-dihydroxyvitamin D(3)-26,23-lactone as end product; Cytochrome P450 family 24 | 0.516 |
| C10orf88 | CYP2R1 | ENSP00000419126 | ENSP00000334592 | Uncharacterized protein C10orf88; Chromosome 10 open reading frame 88 | Vitamin D 25-hydroxylase; Has a D-25-hydroxylase activity on both forms of vitamin D, vitamin D(2) and D(3); Cytochrome P450 family 2 | 0.669 |
| C10orf88 | DHCR7 | ENSP00000419126 | ENSP00000347717 | Uncharacterized protein C10orf88; Chromosome 10 open reading frame 88 | 7-dehydrocholesterol reductase; Production of cholesterol by reduction of C7-C8 double bond of 7-dehydrocholesterol (7-DHC); Belongs to the ERG4/ERG24 family | 0.532 |
| C10orf88 | ENTHD2 | ENSP00000419126 | ENSP00000300714 | Uncharacterized protein C10orf88; Chromosome 10 open reading frame 88 | AP-4 complex accessory subunit Tepsin; Associates with the adapter-like complex 4 (AP-4) and may therefore play a role in vesicular trafficking of proteins at the trans-Golgi network | 0.511 |
| C10orf88 | GIGYF2 | ENSP00000419126 | ENSP00000387170 | Uncharacterized protein C10orf88; Chromosome 10 open reading frame 88 | GRB10-interacting GYF protein 2; Key component of the 4EHP-GYF2 complex, a multiprotein complex that acts as a repressor of translation initiation. In 4EHP-GYF2 the complex, acts as a factor that bridges EIF4E2 to ZFP36/TTP, linking translation repression with mRNA decay (By similarity). May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling, including IGF1 and insulin receptors; Belongs to the GIGYF family | 0.795 |
| C10orf88 | NADSYN1 | ENSP00000419126 | ENSP00000326424 | Uncharacterized protein C10orf88; Chromosome 10 open reading frame 88 | Glutamine-dependent NAD(+) synthetase; NAD synthetase 1; In the C-terminal section; belongs to the NAD synthetase family | 0.732 |
| C10orf88 | RAB11FIP2 | ENSP00000419126 | ENSP00000347839 | Uncharacterized protein C10orf88; Chromosome 10 open reading frame 88 | Rab11 family-interacting protein 2; A Rab11 effector binding preferentially phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and phosphatidic acid (PA) and acting in the regulation of the transport of vesicles from the endosomal recycling compartment (ERC) to the plasma membrane. Involved in insulin granule exocytosis. Also involved in receptor-mediated endocytosis and membrane trafficking of recycling endosomes, probably originating from clathrin-coated vesicles. Required in a complex with MYO5B and RAB11 for the transport of NPC1L1 to the plasma membrane. Also acts as a regulator [...] | 0.597 |
| CACUL1 | C10orf88 | ENSP00000358147 | ENSP00000419126 | CDK2-associated and cullin domain-containing protein 1; Cell cycle associated protein capable of promoting cell proliferation through the activation of CDK2 at the G1/S phase transition | Uncharacterized protein C10orf88; Chromosome 10 open reading frame 88 | 0.576 |
| CYP24A1 | C10orf88 | ENSP00000216862 | ENSP00000419126 | 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial; Has a role in maintaining calcium homeostasis. Catalyzes the NADPH-dependent 24-hydroxylation of calcidiol (25- hydroxyvitamin D(3)) and calcitriol (1-alpha,25-dihydroxyvitamin D(3)). The enzyme can perform up to 6 rounds of hydroxylation of calcitriol leading to calcitroic acid. It also shows 23- hydroxylating activity leading to 1-alpha,25-dihydroxyvitamin D(3)-26,23-lactone as end product; Cytochrome P450 family 24 | Uncharacterized protein C10orf88; Chromosome 10 open reading frame 88 | 0.516 |
| CYP24A1 | CYP2R1 | ENSP00000216862 | ENSP00000334592 | 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial; Has a role in maintaining calcium homeostasis. Catalyzes the NADPH-dependent 24-hydroxylation of calcidiol (25- hydroxyvitamin D(3)) and calcitriol (1-alpha,25-dihydroxyvitamin D(3)). The enzyme can perform up to 6 rounds of hydroxylation of calcitriol leading to calcitroic acid. It also shows 23- hydroxylating activity leading to 1-alpha,25-dihydroxyvitamin D(3)-26,23-lactone as end product; Cytochrome P450 family 24 | Vitamin D 25-hydroxylase; Has a D-25-hydroxylase activity on both forms of vitamin D, vitamin D(2) and D(3); Cytochrome P450 family 2 | 0.946 |
| CYP24A1 | DHCR7 | ENSP00000216862 | ENSP00000347717 | 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial; Has a role in maintaining calcium homeostasis. Catalyzes the NADPH-dependent 24-hydroxylation of calcidiol (25- hydroxyvitamin D(3)) and calcitriol (1-alpha,25-dihydroxyvitamin D(3)). The enzyme can perform up to 6 rounds of hydroxylation of calcitriol leading to calcitroic acid. It also shows 23- hydroxylating activity leading to 1-alpha,25-dihydroxyvitamin D(3)-26,23-lactone as end product; Cytochrome P450 family 24 | 7-dehydrocholesterol reductase; Production of cholesterol by reduction of C7-C8 double bond of 7-dehydrocholesterol (7-DHC); Belongs to the ERG4/ERG24 family | 0.734 |
| CYP24A1 | NADSYN1 | ENSP00000216862 | ENSP00000326424 | 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial; Has a role in maintaining calcium homeostasis. Catalyzes the NADPH-dependent 24-hydroxylation of calcidiol (25- hydroxyvitamin D(3)) and calcitriol (1-alpha,25-dihydroxyvitamin D(3)). The enzyme can perform up to 6 rounds of hydroxylation of calcitriol leading to calcitroic acid. It also shows 23- hydroxylating activity leading to 1-alpha,25-dihydroxyvitamin D(3)-26,23-lactone as end product; Cytochrome P450 family 24 | Glutamine-dependent NAD(+) synthetase; NAD synthetase 1; In the C-terminal section; belongs to the NAD synthetase family | 0.676 |
| CYP2R1 | C10orf88 | ENSP00000334592 | ENSP00000419126 | Vitamin D 25-hydroxylase; Has a D-25-hydroxylase activity on both forms of vitamin D, vitamin D(2) and D(3); Cytochrome P450 family 2 | Uncharacterized protein C10orf88; Chromosome 10 open reading frame 88 | 0.669 |
| CYP2R1 | CYP24A1 | ENSP00000334592 | ENSP00000216862 | Vitamin D 25-hydroxylase; Has a D-25-hydroxylase activity on both forms of vitamin D, vitamin D(2) and D(3); Cytochrome P450 family 2 | 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial; Has a role in maintaining calcium homeostasis. Catalyzes the NADPH-dependent 24-hydroxylation of calcidiol (25- hydroxyvitamin D(3)) and calcitriol (1-alpha,25-dihydroxyvitamin D(3)). The enzyme can perform up to 6 rounds of hydroxylation of calcitriol leading to calcitroic acid. It also shows 23- hydroxylating activity leading to 1-alpha,25-dihydroxyvitamin D(3)-26,23-lactone as end product; Cytochrome P450 family 24 | 0.946 |
| CYP2R1 | DHCR7 | ENSP00000334592 | ENSP00000347717 | Vitamin D 25-hydroxylase; Has a D-25-hydroxylase activity on both forms of vitamin D, vitamin D(2) and D(3); Cytochrome P450 family 2 | 7-dehydrocholesterol reductase; Production of cholesterol by reduction of C7-C8 double bond of 7-dehydrocholesterol (7-DHC); Belongs to the ERG4/ERG24 family | 0.865 |
