| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| COL4A6 | FAM107A | ENSP00000378340 | ENSP00000419124 | Collagen alpha-6(IV) chain; Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a ’chicken-wire’ meshwork together with laminins, proteoglycans and entactin/nidogen | Protein FAM107A; When transfected into cell lines in which it is not expressed, suppresses cell growth. May play a role in tumor development | 0.470 |
| ETNPPL | FAM107A | ENSP00000296486 | ENSP00000419124 | Ethanolamine-phosphate phospho-lyase; Catalyzes the pyridoxal-phosphate-dependent breakdown of phosphoethanolamine, converting it to ammonia, inorganic phosphate and acetaldehyde | Protein FAM107A; When transfected into cell lines in which it is not expressed, suppresses cell growth. May play a role in tumor development | 0.594 |
| FAM107A | COL4A6 | ENSP00000419124 | ENSP00000378340 | Protein FAM107A; When transfected into cell lines in which it is not expressed, suppresses cell growth. May play a role in tumor development | Collagen alpha-6(IV) chain; Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a ’chicken-wire’ meshwork together with laminins, proteoglycans and entactin/nidogen | 0.470 |
| FAM107A | ETNPPL | ENSP00000419124 | ENSP00000296486 | Protein FAM107A; When transfected into cell lines in which it is not expressed, suppresses cell growth. May play a role in tumor development | Ethanolamine-phosphate phospho-lyase; Catalyzes the pyridoxal-phosphate-dependent breakdown of phosphoethanolamine, converting it to ammonia, inorganic phosphate and acetaldehyde | 0.594 |
| FAM107A | GPHA2 | ENSP00000419124 | ENSP00000279168 | Protein FAM107A; When transfected into cell lines in which it is not expressed, suppresses cell growth. May play a role in tumor development | Glycoprotein hormone alpha-2; Functions as a heterodimeric glycoprotein hormone with GPHB5 able to bind and activate the thyroid-stimulating hormone receptor (TSHR), leading to increased cAMP production. Plays a central role in controlling thyroid cell metabolism; Belongs to the glycoprotein hormones subunit alpha family | 0.548 |
| FAM107A | GPM6A | ENSP00000419124 | ENSP00000280187 | Protein FAM107A; When transfected into cell lines in which it is not expressed, suppresses cell growth. May play a role in tumor development | Neuronal membrane glycoprotein M6-a; Involved in neuronal differentiation, including differentiation and migration of neuronal stem cells. Plays a role in neuronal plasticity and is involved in neurite and filopodia outgrowth, filopodia motility and probably synapse formation. GPM6A-induced filopodia formation involves mitogen-activated protein kinase (MAPK) and Src signaling pathways. May be involved in neuronal NGF-dependent Ca(2+) influx. May be involved in regulation of endocytosis and intracellular trafficking of G- protein-coupled receptors (GPCRs); enhances internalization and r [...] | 0.452 |
| FAM107A | HLF | ENSP00000419124 | ENSP00000226067 | Protein FAM107A; When transfected into cell lines in which it is not expressed, suppresses cell growth. May play a role in tumor development | Hepatic leukemia factor; HLF, PAR bZIP transcription factor; Belongs to the bZIP family. PAR subfamily | 0.480 |
| FAM107A | SLCO1C1 | ENSP00000419124 | ENSP00000444149 | Protein FAM107A; When transfected into cell lines in which it is not expressed, suppresses cell growth. May play a role in tumor development | Solute carrier organic anion transporter family member 1C1; Mediates the Na(+)-independent high affinity transport of organic anions such as the thyroid hormones thyroxine (T4) and rT3. Other potential substrates, such as triiodothyronine (T3), 17-beta-glucuronosyl estradiol, estrone-3-sulfate and sulfobromophthalein (BSP) are transported with much lower efficiency. May play a signifiant role in regulating T4 flux into and out of the brain (By similarity); Belongs to the organo anion transporter (TC 2.A.60) family | 0.569 |
| FAM107A | SPARCL1 | ENSP00000419124 | ENSP00000414856 | Protein FAM107A; When transfected into cell lines in which it is not expressed, suppresses cell growth. May play a role in tumor development | SPARC-like protein 1; SPARC family | 0.503 |
| FAM107A | TADA2A | ENSP00000419124 | ENSP00000481091 | Protein FAM107A; When transfected into cell lines in which it is not expressed, suppresses cell growth. May play a role in tumor development | Transcriptional adapter 2-alpha; Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. Required for the function of some acidic activation domains, which activate transcription from a distant site (By similarity). Binds double- stranded DNA. Binds dinucleosomes, probably at the linker region between neighboring nucleosomes. Plays a role in chromatin remodeling. May promote TP53/p53 ’Lys-321’ acetylation, leading to reduced TP53 stability and transcriptional activity. May also promote XRCC6 acetylation thus facilitating cell apoptosis in [...] | 0.533 |
| FAM107A | TERT | ENSP00000419124 | ENSP00000309572 | Protein FAM107A; When transfected into cell lines in which it is not expressed, suppresses cell growth. May play a role in tumor development | Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA- dependent extension of 3’-chromosomal termini with the 6- n [...] | 0.451 |
| FAM107A | TEX264 | ENSP00000419124 | ENSP00000396628 | Protein FAM107A; When transfected into cell lines in which it is not expressed, suppresses cell growth. May play a role in tumor development | Testis-expressed protein 264; Testis expressed 264 | 0.465 |
| GPHA2 | FAM107A | ENSP00000279168 | ENSP00000419124 | Glycoprotein hormone alpha-2; Functions as a heterodimeric glycoprotein hormone with GPHB5 able to bind and activate the thyroid-stimulating hormone receptor (TSHR), leading to increased cAMP production. Plays a central role in controlling thyroid cell metabolism; Belongs to the glycoprotein hormones subunit alpha family | Protein FAM107A; When transfected into cell lines in which it is not expressed, suppresses cell growth. May play a role in tumor development | 0.548 |
| GPM6A | FAM107A | ENSP00000280187 | ENSP00000419124 | Neuronal membrane glycoprotein M6-a; Involved in neuronal differentiation, including differentiation and migration of neuronal stem cells. Plays a role in neuronal plasticity and is involved in neurite and filopodia outgrowth, filopodia motility and probably synapse formation. GPM6A-induced filopodia formation involves mitogen-activated protein kinase (MAPK) and Src signaling pathways. May be involved in neuronal NGF-dependent Ca(2+) influx. May be involved in regulation of endocytosis and intracellular trafficking of G- protein-coupled receptors (GPCRs); enhances internalization and r [...] | Protein FAM107A; When transfected into cell lines in which it is not expressed, suppresses cell growth. May play a role in tumor development | 0.452 |
| HLF | FAM107A | ENSP00000226067 | ENSP00000419124 | Hepatic leukemia factor; HLF, PAR bZIP transcription factor; Belongs to the bZIP family. PAR subfamily | Protein FAM107A; When transfected into cell lines in which it is not expressed, suppresses cell growth. May play a role in tumor development | 0.480 |
| SLCO1C1 | FAM107A | ENSP00000444149 | ENSP00000419124 | Solute carrier organic anion transporter family member 1C1; Mediates the Na(+)-independent high affinity transport of organic anions such as the thyroid hormones thyroxine (T4) and rT3. Other potential substrates, such as triiodothyronine (T3), 17-beta-glucuronosyl estradiol, estrone-3-sulfate and sulfobromophthalein (BSP) are transported with much lower efficiency. May play a signifiant role in regulating T4 flux into and out of the brain (By similarity); Belongs to the organo anion transporter (TC 2.A.60) family | Protein FAM107A; When transfected into cell lines in which it is not expressed, suppresses cell growth. May play a role in tumor development | 0.569 |
| SPARCL1 | FAM107A | ENSP00000414856 | ENSP00000419124 | SPARC-like protein 1; SPARC family | Protein FAM107A; When transfected into cell lines in which it is not expressed, suppresses cell growth. May play a role in tumor development | 0.503 |
| TADA2A | FAM107A | ENSP00000481091 | ENSP00000419124 | Transcriptional adapter 2-alpha; Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. Required for the function of some acidic activation domains, which activate transcription from a distant site (By similarity). Binds double- stranded DNA. Binds dinucleosomes, probably at the linker region between neighboring nucleosomes. Plays a role in chromatin remodeling. May promote TP53/p53 ’Lys-321’ acetylation, leading to reduced TP53 stability and transcriptional activity. May also promote XRCC6 acetylation thus facilitating cell apoptosis in [...] | Protein FAM107A; When transfected into cell lines in which it is not expressed, suppresses cell growth. May play a role in tumor development | 0.533 |
| TERT | FAM107A | ENSP00000309572 | ENSP00000419124 | Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA- dependent extension of 3’-chromosomal termini with the 6- n [...] | Protein FAM107A; When transfected into cell lines in which it is not expressed, suppresses cell growth. May play a role in tumor development | 0.451 |
| TEX264 | FAM107A | ENSP00000396628 | ENSP00000419124 | Testis-expressed protein 264; Testis expressed 264 | Protein FAM107A; When transfected into cell lines in which it is not expressed, suppresses cell growth. May play a role in tumor development | 0.465 |
