node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ALPI | ALPL | ENSP00000295463 | ENSP00000363973 | Alkaline phosphatase, intestinal | Alkaline phosphatase, tissue-nonspecific isozyme; This isozyme may play a role in skeletal mineralization; Belongs to the alkaline phosphatase family | 0.905 |
ALPI | ALPP | ENSP00000295463 | ENSP00000375881 | Alkaline phosphatase, intestinal | Alkaline phosphatase, placental | 0.855 |
ALPI | ALPPL2 | ENSP00000295463 | ENSP00000295453 | Alkaline phosphatase, intestinal | Alkaline phosphatase, placental like 2 | 0.968 |
ALPI | GCH1 | ENSP00000295463 | ENSP00000419045 | Alkaline phosphatase, intestinal | GTP cyclohydrolase 1; Positively regulates nitric oxide synthesis in umbilical vein endothelial cells (HUVECs). May be involved in dopamine synthesis. May modify pain sensitivity and persistence. Isoform GCH-1 is the functional enzyme, the potential function of the enzymatically inactive isoforms remains unknown; Belongs to the GTP cyclohydrolase I family | 0.910 |
ALPI | PTS | ENSP00000295463 | ENSP00000280362 | Alkaline phosphatase, intestinal | 6-pyruvoyl tetrahydrobiopterin synthase; Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6- pyruvoyl tetrahydropterin; Belongs to the PTPS family | 0.917 |
ALPL | ALPI | ENSP00000363973 | ENSP00000295463 | Alkaline phosphatase, tissue-nonspecific isozyme; This isozyme may play a role in skeletal mineralization; Belongs to the alkaline phosphatase family | Alkaline phosphatase, intestinal | 0.905 |
ALPL | ALPPL2 | ENSP00000363973 | ENSP00000295453 | Alkaline phosphatase, tissue-nonspecific isozyme; This isozyme may play a role in skeletal mineralization; Belongs to the alkaline phosphatase family | Alkaline phosphatase, placental like 2 | 0.903 |
ALPL | GCH1 | ENSP00000363973 | ENSP00000419045 | Alkaline phosphatase, tissue-nonspecific isozyme; This isozyme may play a role in skeletal mineralization; Belongs to the alkaline phosphatase family | GTP cyclohydrolase 1; Positively regulates nitric oxide synthesis in umbilical vein endothelial cells (HUVECs). May be involved in dopamine synthesis. May modify pain sensitivity and persistence. Isoform GCH-1 is the functional enzyme, the potential function of the enzymatically inactive isoforms remains unknown; Belongs to the GTP cyclohydrolase I family | 0.910 |
ALPL | PTS | ENSP00000363973 | ENSP00000280362 | Alkaline phosphatase, tissue-nonspecific isozyme; This isozyme may play a role in skeletal mineralization; Belongs to the alkaline phosphatase family | 6-pyruvoyl tetrahydrobiopterin synthase; Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6- pyruvoyl tetrahydropterin; Belongs to the PTPS family | 0.913 |
ALPP | ALPI | ENSP00000375881 | ENSP00000295463 | Alkaline phosphatase, placental | Alkaline phosphatase, intestinal | 0.855 |
ALPP | ALPPL2 | ENSP00000375881 | ENSP00000295453 | Alkaline phosphatase, placental | Alkaline phosphatase, placental like 2 | 0.873 |
ALPP | GCH1 | ENSP00000375881 | ENSP00000419045 | Alkaline phosphatase, placental | GTP cyclohydrolase 1; Positively regulates nitric oxide synthesis in umbilical vein endothelial cells (HUVECs). May be involved in dopamine synthesis. May modify pain sensitivity and persistence. Isoform GCH-1 is the functional enzyme, the potential function of the enzymatically inactive isoforms remains unknown; Belongs to the GTP cyclohydrolase I family | 0.910 |
ALPP | PTS | ENSP00000375881 | ENSP00000280362 | Alkaline phosphatase, placental | 6-pyruvoyl tetrahydrobiopterin synthase; Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6- pyruvoyl tetrahydropterin; Belongs to the PTPS family | 0.913 |
ALPPL2 | ALPI | ENSP00000295453 | ENSP00000295463 | Alkaline phosphatase, placental like 2 | Alkaline phosphatase, intestinal | 0.968 |
ALPPL2 | ALPL | ENSP00000295453 | ENSP00000363973 | Alkaline phosphatase, placental like 2 | Alkaline phosphatase, tissue-nonspecific isozyme; This isozyme may play a role in skeletal mineralization; Belongs to the alkaline phosphatase family | 0.903 |
ALPPL2 | ALPP | ENSP00000295453 | ENSP00000375881 | Alkaline phosphatase, placental like 2 | Alkaline phosphatase, placental | 0.873 |
ALPPL2 | GCH1 | ENSP00000295453 | ENSP00000419045 | Alkaline phosphatase, placental like 2 | GTP cyclohydrolase 1; Positively regulates nitric oxide synthesis in umbilical vein endothelial cells (HUVECs). May be involved in dopamine synthesis. May modify pain sensitivity and persistence. Isoform GCH-1 is the functional enzyme, the potential function of the enzymatically inactive isoforms remains unknown; Belongs to the GTP cyclohydrolase I family | 0.910 |
ALPPL2 | PTS | ENSP00000295453 | ENSP00000280362 | Alkaline phosphatase, placental like 2 | 6-pyruvoyl tetrahydrobiopterin synthase; Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6- pyruvoyl tetrahydropterin; Belongs to the PTPS family | 0.917 |
GCH1 | ALPI | ENSP00000419045 | ENSP00000295463 | GTP cyclohydrolase 1; Positively regulates nitric oxide synthesis in umbilical vein endothelial cells (HUVECs). May be involved in dopamine synthesis. May modify pain sensitivity and persistence. Isoform GCH-1 is the functional enzyme, the potential function of the enzymatically inactive isoforms remains unknown; Belongs to the GTP cyclohydrolase I family | Alkaline phosphatase, intestinal | 0.910 |
GCH1 | ALPL | ENSP00000419045 | ENSP00000363973 | GTP cyclohydrolase 1; Positively regulates nitric oxide synthesis in umbilical vein endothelial cells (HUVECs). May be involved in dopamine synthesis. May modify pain sensitivity and persistence. Isoform GCH-1 is the functional enzyme, the potential function of the enzymatically inactive isoforms remains unknown; Belongs to the GTP cyclohydrolase I family | Alkaline phosphatase, tissue-nonspecific isozyme; This isozyme may play a role in skeletal mineralization; Belongs to the alkaline phosphatase family | 0.910 |