| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| C3orf67 | C6orf222 | ENSP00000295966 | ENSP00000418983 | Uncharacterized protein C3orf67; Chromosome 3 open reading frame 67 | Uncharacterized protein C6orf222; Chromosome 6 open reading frame 222 | 0.513 |
| C6orf222 | C3orf67 | ENSP00000418983 | ENSP00000295966 | Uncharacterized protein C6orf222; Chromosome 6 open reading frame 222 | Uncharacterized protein C3orf67; Chromosome 3 open reading frame 67 | 0.513 |
| C6orf222 | CHMP5 | ENSP00000418983 | ENSP00000223500 | Uncharacterized protein C6orf222; Chromosome 6 open reading frame 222 | Charged multivesicular body protein 5; Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the [...] | 0.536 |
| C6orf222 | FOXJ2 | ENSP00000418983 | ENSP00000162391 | Uncharacterized protein C6orf222; Chromosome 6 open reading frame 222 | Forkhead box protein J2; Transcriptional activator. Able to bind to two different type of DNA binding sites. Isoform FOXJ2.L behaves as a more potent transactivator than FOXJ2.S; Forkhead boxes | 0.524 |
| C6orf222 | MCF2L | ENSP00000418983 | ENSP00000440374 | Uncharacterized protein C6orf222; Chromosome 6 open reading frame 222 | Guanine nucleotide exchange factor DBS; Guanine nucleotide exchange factor that catalyzes guanine nucleotide exchange on RHOA and CDC42, and thereby contributes to the regulation of RHOA and CDC42 signaling pathways (By similarity). Seems to lack activity with RAC1. Becomes activated and highly tumorigenic by truncation of the N-terminus (By similarity). Isoform 5 activates CDC42; Pleckstrin homology domain containing | 0.542 |
| C6orf222 | MRPL41 | ENSP00000418983 | ENSP00000360498 | Uncharacterized protein C6orf222; Chromosome 6 open reading frame 222 | 39S ribosomal protein L41, mitochondrial; Component of the mitochondrial ribosome large subunit. Also involved in apoptosis and cell cycle. Enhances p53/TP53 stability, thereby contributing to p53/TP53-induced apoptosis in response to growth-inhibitory condition. Enhances p53/TP53 translocation to the mitochondria. Has the ability to arrest the cell cycle at the G1 phase, possibly by stabilizing the CDKN1A and CDKN1B (p27Kip1) proteins | 0.538 |
| C6orf222 | NBEAL2 | ENSP00000418983 | ENSP00000415034 | Uncharacterized protein C6orf222; Chromosome 6 open reading frame 222 | Neurobeachin-like protein 2; Probably involved in thrombopoiesis. Plays a role in the development or secretion of alpha-granules, that contain several growth factors important for platelet biogenesis; Armadillo-like helical domain containing | 0.512 |
| C6orf222 | POFUT2 | ENSP00000418983 | ENSP00000339613 | Uncharacterized protein C6orf222; Chromosome 6 open reading frame 222 | GDP-fucose protein O-fucosyltransferase 2; Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine residue in the consensus sequence C1-X(2,3)-S/T-C2-X(2)-G of thrombospondin type 1 repeats where C1 and C2 are the first and second cysteines, respectively. O-fucosylates members of several protein families including the ADAMTS family, the thrombosporin (TSP) and spondin families. The O-fucosylation of TSRs is also required for restricting epithelial to mesenchymal transition (EMT), maintaining the correct patterning of mesoderm and l [...] | 0.577 |
| C6orf222 | PURB | ENSP00000418983 | ENSP00000379051 | Uncharacterized protein C6orf222; Chromosome 6 open reading frame 222 | Transcriptional activator protein Pur-beta; Has capacity to bind repeated elements in single- stranded DNA such as the purine-rich single strand of the PUR element located upstream of the MYC gene. Plays a role in the control of vascular smooth muscle (VSM) alpha-actin gene transcription as repressor in myoblasts and fibroblasts. Participates in transcriptional and translational regulation of alpha-MHC expression in cardiac myocytes by binding to the purine- rich negative regulatory (PNR) element. Modulates constitutive liver galectin-3 gene transcription by binding to its promoter. Ma [...] | 0.571 |
| C6orf222 | PXT1 | ENSP00000418983 | ENSP00000419944 | Uncharacterized protein C6orf222; Chromosome 6 open reading frame 222 | Peroxisomal, testis specific 1 | 0.533 |
| C6orf222 | SPNS1 | ENSP00000418983 | ENSP00000309945 | Uncharacterized protein C6orf222; Chromosome 6 open reading frame 222 | Protein spinster homolog 1; Sphingolipid transporter (By similarity). May be involved in necrotic or autophagic cell death | 0.587 |
| CHMP5 | C6orf222 | ENSP00000223500 | ENSP00000418983 | Charged multivesicular body protein 5; Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the [...] | Uncharacterized protein C6orf222; Chromosome 6 open reading frame 222 | 0.536 |
| FOXJ2 | C6orf222 | ENSP00000162391 | ENSP00000418983 | Forkhead box protein J2; Transcriptional activator. Able to bind to two different type of DNA binding sites. Isoform FOXJ2.L behaves as a more potent transactivator than FOXJ2.S; Forkhead boxes | Uncharacterized protein C6orf222; Chromosome 6 open reading frame 222 | 0.524 |
| MCF2L | C6orf222 | ENSP00000440374 | ENSP00000418983 | Guanine nucleotide exchange factor DBS; Guanine nucleotide exchange factor that catalyzes guanine nucleotide exchange on RHOA and CDC42, and thereby contributes to the regulation of RHOA and CDC42 signaling pathways (By similarity). Seems to lack activity with RAC1. Becomes activated and highly tumorigenic by truncation of the N-terminus (By similarity). Isoform 5 activates CDC42; Pleckstrin homology domain containing | Uncharacterized protein C6orf222; Chromosome 6 open reading frame 222 | 0.542 |
| MRPL41 | C6orf222 | ENSP00000360498 | ENSP00000418983 | 39S ribosomal protein L41, mitochondrial; Component of the mitochondrial ribosome large subunit. Also involved in apoptosis and cell cycle. Enhances p53/TP53 stability, thereby contributing to p53/TP53-induced apoptosis in response to growth-inhibitory condition. Enhances p53/TP53 translocation to the mitochondria. Has the ability to arrest the cell cycle at the G1 phase, possibly by stabilizing the CDKN1A and CDKN1B (p27Kip1) proteins | Uncharacterized protein C6orf222; Chromosome 6 open reading frame 222 | 0.538 |
| NBEAL2 | C6orf222 | ENSP00000415034 | ENSP00000418983 | Neurobeachin-like protein 2; Probably involved in thrombopoiesis. Plays a role in the development or secretion of alpha-granules, that contain several growth factors important for platelet biogenesis; Armadillo-like helical domain containing | Uncharacterized protein C6orf222; Chromosome 6 open reading frame 222 | 0.512 |
| POFUT2 | C6orf222 | ENSP00000339613 | ENSP00000418983 | GDP-fucose protein O-fucosyltransferase 2; Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine residue in the consensus sequence C1-X(2,3)-S/T-C2-X(2)-G of thrombospondin type 1 repeats where C1 and C2 are the first and second cysteines, respectively. O-fucosylates members of several protein families including the ADAMTS family, the thrombosporin (TSP) and spondin families. The O-fucosylation of TSRs is also required for restricting epithelial to mesenchymal transition (EMT), maintaining the correct patterning of mesoderm and l [...] | Uncharacterized protein C6orf222; Chromosome 6 open reading frame 222 | 0.577 |
| PURB | C6orf222 | ENSP00000379051 | ENSP00000418983 | Transcriptional activator protein Pur-beta; Has capacity to bind repeated elements in single- stranded DNA such as the purine-rich single strand of the PUR element located upstream of the MYC gene. Plays a role in the control of vascular smooth muscle (VSM) alpha-actin gene transcription as repressor in myoblasts and fibroblasts. Participates in transcriptional and translational regulation of alpha-MHC expression in cardiac myocytes by binding to the purine- rich negative regulatory (PNR) element. Modulates constitutive liver galectin-3 gene transcription by binding to its promoter. Ma [...] | Uncharacterized protein C6orf222; Chromosome 6 open reading frame 222 | 0.571 |
| PXT1 | C6orf222 | ENSP00000419944 | ENSP00000418983 | Peroxisomal, testis specific 1 | Uncharacterized protein C6orf222; Chromosome 6 open reading frame 222 | 0.533 |
| SPNS1 | C6orf222 | ENSP00000309945 | ENSP00000418983 | Protein spinster homolog 1; Sphingolipid transporter (By similarity). May be involved in necrotic or autophagic cell death | Uncharacterized protein C6orf222; Chromosome 6 open reading frame 222 | 0.587 |
