node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ATIC | PURG | ENSP00000236959 | ENSP00000418721 | Bifunctional purine biosynthesis protein PURH; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis; Belongs to the PurH family | Purine-rich element-binding protein gamma; Purine rich element binding protein G | 0.666 |
H2AFY2 | HIST1H1A | ENSP00000362352 | ENSP00000244573 | Core histone macro-H2A.2; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post- translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in stable X chromosome inac [...] | Histone H1.1; Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity) | 0.543 |
H2AFY2 | PURG | ENSP00000362352 | ENSP00000418721 | Core histone macro-H2A.2; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post- translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in stable X chromosome inac [...] | Purine-rich element-binding protein gamma; Purine rich element binding protein G | 0.457 |
HIST1H1A | H2AFY2 | ENSP00000244573 | ENSP00000362352 | Histone H1.1; Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity) | Core histone macro-H2A.2; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post- translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in stable X chromosome inac [...] | 0.543 |
HIST1H1A | PURG | ENSP00000244573 | ENSP00000418721 | Histone H1.1; Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity) | Purine-rich element-binding protein gamma; Purine rich element binding protein G | 0.430 |
LRRC34 | PRSS22 | ENSP00000414635 | ENSP00000161006 | Leucine-rich repeat-containing protein 34; Highly expressed in stem cells where it may be involved in regulation of pluripotency. In embryonic stem cells (ESCs), important for normal expression of the pluripotency regulators POU5F1/OCT4 and KLF4. Also important for expression of the ectodermal marker gene NES and the endodermal marker gene GATA4. Promotes stem cell proliferation in vitro | Brain-specific serine protease 4; Preferentially cleaves the synthetic substrate H-D-Leu- Thr-Arg-pNA compared to tosyl-Gly-Pro-Arg-pNA; Serine proteases | 0.420 |
LRRC34 | PURG | ENSP00000414635 | ENSP00000418721 | Leucine-rich repeat-containing protein 34; Highly expressed in stem cells where it may be involved in regulation of pluripotency. In embryonic stem cells (ESCs), important for normal expression of the pluripotency regulators POU5F1/OCT4 and KLF4. Also important for expression of the ectodermal marker gene NES and the endodermal marker gene GATA4. Promotes stem cell proliferation in vitro | Purine-rich element-binding protein gamma; Purine rich element binding protein G | 0.558 |
LRRC34 | TMEM69 | ENSP00000414635 | ENSP00000361095 | Leucine-rich repeat-containing protein 34; Highly expressed in stem cells where it may be involved in regulation of pluripotency. In embryonic stem cells (ESCs), important for normal expression of the pluripotency regulators POU5F1/OCT4 and KLF4. Also important for expression of the ectodermal marker gene NES and the endodermal marker gene GATA4. Promotes stem cell proliferation in vitro | Transmembrane protein 69 | 0.520 |
PRSS22 | LRRC34 | ENSP00000161006 | ENSP00000414635 | Brain-specific serine protease 4; Preferentially cleaves the synthetic substrate H-D-Leu- Thr-Arg-pNA compared to tosyl-Gly-Pro-Arg-pNA; Serine proteases | Leucine-rich repeat-containing protein 34; Highly expressed in stem cells where it may be involved in regulation of pluripotency. In embryonic stem cells (ESCs), important for normal expression of the pluripotency regulators POU5F1/OCT4 and KLF4. Also important for expression of the ectodermal marker gene NES and the endodermal marker gene GATA4. Promotes stem cell proliferation in vitro | 0.420 |
PRSS22 | PURG | ENSP00000161006 | ENSP00000418721 | Brain-specific serine protease 4; Preferentially cleaves the synthetic substrate H-D-Leu- Thr-Arg-pNA compared to tosyl-Gly-Pro-Arg-pNA; Serine proteases | Purine-rich element-binding protein gamma; Purine rich element binding protein G | 0.473 |
PRSS22 | TMEM69 | ENSP00000161006 | ENSP00000361095 | Brain-specific serine protease 4; Preferentially cleaves the synthetic substrate H-D-Leu- Thr-Arg-pNA compared to tosyl-Gly-Pro-Arg-pNA; Serine proteases | Transmembrane protein 69 | 0.472 |
PURG | ATIC | ENSP00000418721 | ENSP00000236959 | Purine-rich element-binding protein gamma; Purine rich element binding protein G | Bifunctional purine biosynthesis protein PURH; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis; Belongs to the PurH family | 0.666 |
PURG | H2AFY2 | ENSP00000418721 | ENSP00000362352 | Purine-rich element-binding protein gamma; Purine rich element binding protein G | Core histone macro-H2A.2; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post- translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in stable X chromosome inac [...] | 0.457 |
PURG | HIST1H1A | ENSP00000418721 | ENSP00000244573 | Purine-rich element-binding protein gamma; Purine rich element binding protein G | Histone H1.1; Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity) | 0.430 |
PURG | LRRC34 | ENSP00000418721 | ENSP00000414635 | Purine-rich element-binding protein gamma; Purine rich element binding protein G | Leucine-rich repeat-containing protein 34; Highly expressed in stem cells where it may be involved in regulation of pluripotency. In embryonic stem cells (ESCs), important for normal expression of the pluripotency regulators POU5F1/OCT4 and KLF4. Also important for expression of the ectodermal marker gene NES and the endodermal marker gene GATA4. Promotes stem cell proliferation in vitro | 0.558 |
PURG | PRSS22 | ENSP00000418721 | ENSP00000161006 | Purine-rich element-binding protein gamma; Purine rich element binding protein G | Brain-specific serine protease 4; Preferentially cleaves the synthetic substrate H-D-Leu- Thr-Arg-pNA compared to tosyl-Gly-Pro-Arg-pNA; Serine proteases | 0.473 |
PURG | RIC1 | ENSP00000418721 | ENSP00000416696 | Purine-rich element-binding protein gamma; Purine rich element binding protein G | RAB6A-GEF complex partner protein 1; The RIC1-RGP1 complex acts as a guanine nucleotide exchange factor (GEF), which activates RAB6A by exchanging bound GDP for free GTP and may thereby required for efficient fusion of endosome-derived vesicles with the Golgi compartment. The RIC1- RGP1 complex participates in the recycling of mannose-6-phosphate receptors. Required for phosphorylation and localization of GJA1; WD repeat domain containing | 0.424 |
PURG | TMEM261 | ENSP00000418721 | ENSP00000350961 | Purine-rich element-binding protein gamma; Purine rich element binding protein G | Distal membrane-arm assembly complex protein 1; Required for the assembly of the mitochondrial NADH-ubiquinone oxidoreductase complex (complex I). Involved in the assembly of the distal region of complex I | 0.558 |
PURG | TMEM69 | ENSP00000418721 | ENSP00000361095 | Purine-rich element-binding protein gamma; Purine rich element binding protein G | Transmembrane protein 69 | 0.560 |
PURG | WDR43 | ENSP00000418721 | ENSP00000384302 | Purine-rich element-binding protein gamma; Purine rich element binding protein G | WD repeat-containing protein 43; Ribosome biogenesis factor. Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre- ribosomal RNA transcription by RNA polymerase I; Belongs to the UTP5 family | 0.430 |