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STRINGSTRING
PDLIM5 PDLIM5 GADD45G GADD45G FAM24B FAM24B RWDD2B RWDD2B USP16 USP16 ENSG00000272693 ENSG00000272693 ZNHIT2 ZNHIT2 UBN2 UBN2 KLRG2 KLRG2 CTTNBP2 CTTNBP2 JSRP1 JSRP1
"RWDD2B" - RWD domain containing 2B in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Experiments
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[Homology]
Score
RWDD2BRWD domain containing 2B (319 aa)    
Predicted Functional Partners:
PDLIM5
PDZ and LIM domain protein 5; May play an important role in the heart development by scaffolding PKC to the Z-disk region. May play a role in the regulation of cardiomyocyte expansion. Overexpression promotes the development of heart hypertrophy. Contributes to the regulation of dendritic spine morphogenesis in neurons. May restrain postsynaptic growth of excitatory synapses (By similarity); LIM domain containing (625 aa)
        
      0.795
UBN2
Ubinuclein-2; Ubinuclein 2; Belongs to the ubinuclein family (1347 aa)
            
  0.737
KLRG2
Killer cell lectin like receptor G2; C-type lectin domain containing (409 aa)
            
  0.704
JSRP1
Junctional sarcoplasmic reticulum protein 1; Involved in skeletal muscle excitation/contraction coupling (EC), probably acting as a regulator of the voltage- sensitive calcium channel CACNA1S. EC is a physiological process whereby an electrical signal (depolarization of the plasma membrane) is converted into a chemical signal, a calcium gradient, by the opening of ryanodine receptor calcium release channels. May regulate CACNA1S membrane targeting and activity (331 aa)
            
  0.700
USP16
Ubiquitin carboxyl-terminal hydrolase 16; Specifically deubiquitinates ’Lys-120’ of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at ’Ser-11’ of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis. In resting B- and T- lymphocytes, phosphorylation by AURKB leads to enhance its activity, thereby maintaining transcription in resting lymphocytes. Regulates Hox gene expression via histone H2A deubiq [...] (823 aa)
      
   
  0.676
GADD45G
Growth arrest and DNA damage-inducible protein GADD45 gamma; Involved in the regulation of growth and apoptosis. Mediates activation of stress-responsive MTK1/MEKK4 MAPKKK; Belongs to the GADD45 family (159 aa)
        
      0.671
FAM24B
Protein FAM24B; Family with sequence similarity 24 member B (94 aa)
            
  0.669
ENSG00000272693
annotation not available (301 aa)
            
  0.645
ZNHIT2
Zinc finger HIT-type containing 2 (403 aa)
      
   
  0.641
CTTNBP2
Cortactin-binding protein 2; Regulates the dendritic spine distribution of CTTN/cortactin in hippocampal neurons, thus controls dendritic spinogenesis and dendritic spine maintenance; Ankyrin repeat domain containing (1663 aa)
            
  0.626
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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