node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AZI2 | CMC1 | ENSP00000419371 | ENSP00000418348 | 5-azacytidine-induced protein 2; Adapter protein which binds TBK1 and IKBKE playing a role in antiviral innate immunity. Activates serine/threonine- protein kinase TBK1 and facilitates its oligomerization. Enhances the phosphorylation of NF-kappa-B p65 subunit RELA by TBK1. Promotes TBK1-induced as well as TNF-alpha or PMA-induced activation of NF-kappa-B. Participates in IFNB promoter activation via TICAM1 | COX assembly mitochondrial protein homolog; Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly | 0.816 |
AZI2 | RBMS3 | ENSP00000419371 | ENSP00000373277 | 5-azacytidine-induced protein 2; Adapter protein which binds TBK1 and IKBKE playing a role in antiviral innate immunity. Activates serine/threonine- protein kinase TBK1 and facilitates its oligomerization. Enhances the phosphorylation of NF-kappa-B p65 subunit RELA by TBK1. Promotes TBK1-induced as well as TNF-alpha or PMA-induced activation of NF-kappa-B. Participates in IFNB promoter activation via TICAM1 | RNA-binding motif, single-stranded-interacting protein 3; Binds poly(A) and poly(U) oligoribonucleotides; RNA binding motif containing | 0.655 |
CHCHD7 | CMC1 | ENSP00000306425 | ENSP00000418348 | Mitochondrial coiled-coil-helix-coiled-coil-helix domain containing proteins; Belongs to the CHCHD7 family | COX assembly mitochondrial protein homolog; Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly | 0.546 |
CHCHD7 | COA5 | ENSP00000306425 | ENSP00000330730 | Mitochondrial coiled-coil-helix-coiled-coil-helix domain containing proteins; Belongs to the CHCHD7 family | Cytochrome c oxidase assembly factor 5; Involved in an early step of the mitochondrial complex IV assembly process | 0.860 |
CHCHD7 | COA6 | ENSP00000306425 | ENSP00000355572 | Mitochondrial coiled-coil-helix-coiled-coil-helix domain containing proteins; Belongs to the CHCHD7 family | Cytochrome c oxidase assembly factor 6 homolog; Involved in the maturation of the mitochondrial respiratory chain complex IV subunit MT-CO2/COX2. Thereby, may regulate early steps of complex IV assembly. Mitochondrial respiratory chain complex IV or cytochrome c oxidase is the component of the respiratory chain that catalyzes the transfer of electrons from intermembrane space cytochrome c to molecular oxygen in the matrix and as a consequence contributes to the proton gradient involved in mitochondrial ATP synthesis. May also be required for efficient formation of respiratory supercomp [...] | 0.636 |
CHCHD7 | COX19 | ENSP00000306425 | ENSP00000342015 | Mitochondrial coiled-coil-helix-coiled-coil-helix domain containing proteins; Belongs to the CHCHD7 family | Cytochrome c oxidase assembly protein COX19; May be required for the assembly of mitochondrial cytochrome c oxidase; Mitochondrial respiratory chain complex assembly factors | 0.893 |
CHCHD7 | PET117 | ENSP00000306425 | ENSP00000397881 | Mitochondrial coiled-coil-helix-coiled-coil-helix domain containing proteins; Belongs to the CHCHD7 family | Protein PET117 homolog, mitochondrial; PET117 homolog | 0.443 |
CMC1 | AZI2 | ENSP00000418348 | ENSP00000419371 | COX assembly mitochondrial protein homolog; Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly | 5-azacytidine-induced protein 2; Adapter protein which binds TBK1 and IKBKE playing a role in antiviral innate immunity. Activates serine/threonine- protein kinase TBK1 and facilitates its oligomerization. Enhances the phosphorylation of NF-kappa-B p65 subunit RELA by TBK1. Promotes TBK1-induced as well as TNF-alpha or PMA-induced activation of NF-kappa-B. Participates in IFNB promoter activation via TICAM1 | 0.816 |
CMC1 | CHCHD7 | ENSP00000418348 | ENSP00000306425 | COX assembly mitochondrial protein homolog; Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly | Mitochondrial coiled-coil-helix-coiled-coil-helix domain containing proteins; Belongs to the CHCHD7 family | 0.546 |
CMC1 | CMC2 | ENSP00000418348 | ENSP00000219400 | COX assembly mitochondrial protein homolog; Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly | COX assembly mitochondrial protein 2 homolog; May be involved in cytochrome c oxidase biogenesis | 0.610 |
CMC1 | COA5 | ENSP00000418348 | ENSP00000330730 | COX assembly mitochondrial protein homolog; Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly | Cytochrome c oxidase assembly factor 5; Involved in an early step of the mitochondrial complex IV assembly process | 0.652 |
CMC1 | COA6 | ENSP00000418348 | ENSP00000355572 | COX assembly mitochondrial protein homolog; Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly | Cytochrome c oxidase assembly factor 6 homolog; Involved in the maturation of the mitochondrial respiratory chain complex IV subunit MT-CO2/COX2. Thereby, may regulate early steps of complex IV assembly. Mitochondrial respiratory chain complex IV or cytochrome c oxidase is the component of the respiratory chain that catalyzes the transfer of electrons from intermembrane space cytochrome c to molecular oxygen in the matrix and as a consequence contributes to the proton gradient involved in mitochondrial ATP synthesis. May also be required for efficient formation of respiratory supercomp [...] | 0.514 |
CMC1 | COX16 | ENSP00000418348 | ENSP00000374562 | COX assembly mitochondrial protein homolog; Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly | COX16, cytochrome c oxidase assembly homolog; Belongs to the COX16 family | 0.611 |
CMC1 | COX19 | ENSP00000418348 | ENSP00000342015 | COX assembly mitochondrial protein homolog; Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly | Cytochrome c oxidase assembly protein COX19; May be required for the assembly of mitochondrial cytochrome c oxidase; Mitochondrial respiratory chain complex assembly factors | 0.645 |
CMC1 | PET100 | ENSP00000418348 | ENSP00000470539 | COX assembly mitochondrial protein homolog; Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly | Protein PET100 homolog, mitochondrial; PET100 homolog; Belongs to the PET100 family | 0.563 |
CMC1 | PET117 | ENSP00000418348 | ENSP00000397881 | COX assembly mitochondrial protein homolog; Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly | Protein PET117 homolog, mitochondrial; PET117 homolog | 0.615 |
CMC1 | RBMS3 | ENSP00000418348 | ENSP00000373277 | COX assembly mitochondrial protein homolog; Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly | RNA-binding motif, single-stranded-interacting protein 3; Binds poly(A) and poly(U) oligoribonucleotides; RNA binding motif containing | 0.693 |
CMC2 | CMC1 | ENSP00000219400 | ENSP00000418348 | COX assembly mitochondrial protein 2 homolog; May be involved in cytochrome c oxidase biogenesis | COX assembly mitochondrial protein homolog; Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly | 0.610 |
CMC2 | COA5 | ENSP00000219400 | ENSP00000330730 | COX assembly mitochondrial protein 2 homolog; May be involved in cytochrome c oxidase biogenesis | Cytochrome c oxidase assembly factor 5; Involved in an early step of the mitochondrial complex IV assembly process | 0.444 |
COA5 | CHCHD7 | ENSP00000330730 | ENSP00000306425 | Cytochrome c oxidase assembly factor 5; Involved in an early step of the mitochondrial complex IV assembly process | Mitochondrial coiled-coil-helix-coiled-coil-helix domain containing proteins; Belongs to the CHCHD7 family | 0.860 |