• Version:
  • 11.0 [archived version]
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RBMS3 RBMS3 PET100 PET100 AZI2 AZI2 PET117 PET117 CMC1 CMC1 COA6 COA6 COA5 COA5 CHCHD7 CHCHD7 CMC2 CMC2 COX19 COX19 COX16 COX16
"CMC1" - COX assembly mitochondrial protein homolog in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
CMC1COX assembly mitochondrial protein homolog; Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly (106 aa)    
Predicted Functional Partners:
AZI2
5-azacytidine-induced protein 2; Adapter protein which binds TBK1 and IKBKE playing a role in antiviral innate immunity. Activates serine/threonine- protein kinase TBK1 and facilitates its oligomerization. Enhances the phosphorylation of NF-kappa-B p65 subunit RELA by TBK1. Promotes TBK1-induced as well as TNF-alpha or PMA-induced activation of NF-kappa-B. Participates in IFNB promoter activation via TICAM1 (392 aa)
           
  0.816
RBMS3
RNA-binding motif, single-stranded-interacting protein 3; Binds poly(A) and poly(U) oligoribonucleotides; RNA binding motif containing (437 aa)
           
  0.693
COA5
Cytochrome c oxidase assembly factor 5; Involved in an early step of the mitochondrial complex IV assembly process (74 aa)
     
   
  0.652
COX19
Cytochrome c oxidase assembly protein COX19; May be required for the assembly of mitochondrial cytochrome c oxidase; Mitochondrial respiratory chain complex assembly factors (90 aa)
     
   
  0.645
PET117
Protein PET117 homolog, mitochondrial; PET117 homolog (81 aa)
           
  0.615
COX16
COX16, cytochrome c oxidase assembly homolog; Belongs to the COX16 family (106 aa)
     
   
  0.611
CMC2
COX assembly mitochondrial protein 2 homolog; May be involved in cytochrome c oxidase biogenesis (79 aa)
     
 
  0.610
PET100
Protein PET100 homolog, mitochondrial; PET100 homolog; Belongs to the PET100 family (73 aa)
     
   
  0.563
CHCHD7
Mitochondrial coiled-coil-helix-coiled-coil-helix domain containing proteins; Belongs to the CHCHD7 family (110 aa)
     
   
  0.546
COA6
Cytochrome c oxidase assembly factor 6 homolog; Involved in the maturation of the mitochondrial respiratory chain complex IV subunit MT-CO2/COX2. Thereby, may regulate early steps of complex IV assembly. Mitochondrial respiratory chain complex IV or cytochrome c oxidase is the component of the respiratory chain that catalyzes the transfer of electrons from intermembrane space cytochrome c to molecular oxygen in the matrix and as a consequence contributes to the proton gradient involved in mitochondrial ATP synthesis. May also be required for efficient formation of respiratory supercomp [...] (125 aa)
           
  0.514
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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