| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CABLES1 | PTCHD3 | ENSP00000256925 | ENSP00000417658 | CDK5 and ABL1 enzyme substrate 1; Cyclin-dependent kinase binding protein. Enhances cyclin-dependent kinase tyrosine phosphorylation by nonreceptor tyrosine kinases, such as that of CDK5 by activated ABL1, which leads to increased CDK5 activity and is critical for neuronal development, and that of CDK2 by WEE1, which leads to decreased CDK2 activity and growth inhibition. Positively affects neuronal outgrowth. Plays a role as a regulator for p53/p73-induced cell death (By similarity) | Patched domain-containing protein 3; May play a role in sperm development or sperm function | 0.582 |
| ENC1 | GPR85 | ENSP00000479101 | ENSP00000297146 | Ectoderm-neural cortex protein 1; Actin-binding protein involved in the regulation of neuronal process formation and in differentiation of neural crest cells. Down-regulates transcription factor NF2L2/NRF2 by decreasing the rate of protein synthesis and not via a ubiquitin- mediated proteasomal degradation mechanism; BTB domain containing | Probable G-protein coupled receptor 85; Orphan receptor; Belongs to the G-protein coupled receptor 1 family | 0.740 |
| ENC1 | MGEA5 | ENSP00000479101 | ENSP00000354850 | Ectoderm-neural cortex protein 1; Actin-binding protein involved in the regulation of neuronal process formation and in differentiation of neural crest cells. Down-regulates transcription factor NF2L2/NRF2 by decreasing the rate of protein synthesis and not via a ubiquitin- mediated proteasomal degradation mechanism; BTB domain containing | Protein O-GlcNAcase; Isoform 1- Cleaves GlcNAc but not GalNAc from O- glycosylated proteins. Can use p-nitrophenyl-beta-GlcNAc and 4- methylumbelliferone-GlcNAc as substrates but not p-nitrophenyl- beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro). Does not bind acetyl-CoA and does not have histone acetyltransferase activity; Belongs to the glycosyl hydrolase 84 family | 0.651 |
| ENC1 | PTCHD3 | ENSP00000479101 | ENSP00000417658 | Ectoderm-neural cortex protein 1; Actin-binding protein involved in the regulation of neuronal process formation and in differentiation of neural crest cells. Down-regulates transcription factor NF2L2/NRF2 by decreasing the rate of protein synthesis and not via a ubiquitin- mediated proteasomal degradation mechanism; BTB domain containing | Patched domain-containing protein 3; May play a role in sperm development or sperm function | 0.716 |
| ENC1 | SNX33 | ENSP00000479101 | ENSP00000311427 | Ectoderm-neural cortex protein 1; Actin-binding protein involved in the regulation of neuronal process formation and in differentiation of neural crest cells. Down-regulates transcription factor NF2L2/NRF2 by decreasing the rate of protein synthesis and not via a ubiquitin- mediated proteasomal degradation mechanism; BTB domain containing | Sorting nexin-33; Plays a role in the reorganization of the cytoskeleton, endocytosis and cellular vesicle trafficking via its interactions with membranes, WASL, DNM1 and DNM2. Acts both during interphase and at the end of mitotic cell divisions. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Modulates endocytosis of cell-surface proteins, such as APP and PRNP; this then modulates the secretion of APP and PRNP peptides. Promotes membrane tubulation (in vitro). May promote the formation of macr [...] | 0.799 |
| ENC1 | TBR1 | ENSP00000479101 | ENSP00000374205 | Ectoderm-neural cortex protein 1; Actin-binding protein involved in the regulation of neuronal process formation and in differentiation of neural crest cells. Down-regulates transcription factor NF2L2/NRF2 by decreasing the rate of protein synthesis and not via a ubiquitin- mediated proteasomal degradation mechanism; BTB domain containing | T-box brain protein 1; Probable transcriptional regulator involved in developmental processes. Required for normal brain development; T-boxes | 0.715 |
| GPR85 | ENC1 | ENSP00000297146 | ENSP00000479101 | Probable G-protein coupled receptor 85; Orphan receptor; Belongs to the G-protein coupled receptor 1 family | Ectoderm-neural cortex protein 1; Actin-binding protein involved in the regulation of neuronal process formation and in differentiation of neural crest cells. Down-regulates transcription factor NF2L2/NRF2 by decreasing the rate of protein synthesis and not via a ubiquitin- mediated proteasomal degradation mechanism; BTB domain containing | 0.740 |
| GPR85 | PTCHD3 | ENSP00000297146 | ENSP00000417658 | Probable G-protein coupled receptor 85; Orphan receptor; Belongs to the G-protein coupled receptor 1 family | Patched domain-containing protein 3; May play a role in sperm development or sperm function | 0.674 |
| GPR85 | SNX33 | ENSP00000297146 | ENSP00000311427 | Probable G-protein coupled receptor 85; Orphan receptor; Belongs to the G-protein coupled receptor 1 family | Sorting nexin-33; Plays a role in the reorganization of the cytoskeleton, endocytosis and cellular vesicle trafficking via its interactions with membranes, WASL, DNM1 and DNM2. Acts both during interphase and at the end of mitotic cell divisions. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Modulates endocytosis of cell-surface proteins, such as APP and PRNP; this then modulates the secretion of APP and PRNP peptides. Promotes membrane tubulation (in vitro). May promote the formation of macr [...] | 0.609 |
| GPR85 | TBR1 | ENSP00000297146 | ENSP00000374205 | Probable G-protein coupled receptor 85; Orphan receptor; Belongs to the G-protein coupled receptor 1 family | T-box brain protein 1; Probable transcriptional regulator involved in developmental processes. Required for normal brain development; T-boxes | 0.587 |
| IGSF9 | PTCHD3 | ENSP00000357073 | ENSP00000417658 | Protein turtle homolog A; Functions in dendrite outgrowth and synapse maturation; Belongs to the immunoglobulin superfamily. Turtle family | Patched domain-containing protein 3; May play a role in sperm development or sperm function | 0.723 |
| MGEA5 | ENC1 | ENSP00000354850 | ENSP00000479101 | Protein O-GlcNAcase; Isoform 1- Cleaves GlcNAc but not GalNAc from O- glycosylated proteins. Can use p-nitrophenyl-beta-GlcNAc and 4- methylumbelliferone-GlcNAc as substrates but not p-nitrophenyl- beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro). Does not bind acetyl-CoA and does not have histone acetyltransferase activity; Belongs to the glycosyl hydrolase 84 family | Ectoderm-neural cortex protein 1; Actin-binding protein involved in the regulation of neuronal process formation and in differentiation of neural crest cells. Down-regulates transcription factor NF2L2/NRF2 by decreasing the rate of protein synthesis and not via a ubiquitin- mediated proteasomal degradation mechanism; BTB domain containing | 0.651 |
| MGEA5 | PTCHD3 | ENSP00000354850 | ENSP00000417658 | Protein O-GlcNAcase; Isoform 1- Cleaves GlcNAc but not GalNAc from O- glycosylated proteins. Can use p-nitrophenyl-beta-GlcNAc and 4- methylumbelliferone-GlcNAc as substrates but not p-nitrophenyl- beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro). Does not bind acetyl-CoA and does not have histone acetyltransferase activity; Belongs to the glycosyl hydrolase 84 family | Patched domain-containing protein 3; May play a role in sperm development or sperm function | 0.556 |
| NLRP12 | PTCHD3 | ENSP00000375653 | ENSP00000417658 | NACHT, LRR and PYD domains-containing protein 12; May mediate activation of CASP1 via ASC and promote activation of NF-kappa-B via IKK; NLR family | Patched domain-containing protein 3; May play a role in sperm development or sperm function | 0.670 |
| PHAX | PTCHD3 | ENSP00000297540 | ENSP00000417658 | Phosphorylated adapter RNA export protein; A phosphoprotein adapter involved in the XPO1-mediated U snRNA export from the nucleus. Bridge components required for U snRNA export, the cap binding complex (CBC)-bound snRNA on the one hand and the GTPase Ran in its active GTP-bound form together with the export receptor XPO1 on the other. Its phosphorylation in the nucleus is required for U snRNA export complex assembly and export, while its dephosphorylation in the cytoplasm causes export complex disassembly. It is recycled back to the nucleus via the importin alpha/beta heterodimeric imp [...] | Patched domain-containing protein 3; May play a role in sperm development or sperm function | 0.572 |
| PPY | PTCHD3 | ENSP00000466009 | ENSP00000417658 | Pancreatic prohormone; Pancreatic hormone is synthesized in pancreatic islets of Langerhans and acts as a regulator of pancreatic and gastrointestinal functions; Endogenous ligands | Patched domain-containing protein 3; May play a role in sperm development or sperm function | 0.724 |
| PTCHD3 | CABLES1 | ENSP00000417658 | ENSP00000256925 | Patched domain-containing protein 3; May play a role in sperm development or sperm function | CDK5 and ABL1 enzyme substrate 1; Cyclin-dependent kinase binding protein. Enhances cyclin-dependent kinase tyrosine phosphorylation by nonreceptor tyrosine kinases, such as that of CDK5 by activated ABL1, which leads to increased CDK5 activity and is critical for neuronal development, and that of CDK2 by WEE1, which leads to decreased CDK2 activity and growth inhibition. Positively affects neuronal outgrowth. Plays a role as a regulator for p53/p73-induced cell death (By similarity) | 0.582 |
| PTCHD3 | ENC1 | ENSP00000417658 | ENSP00000479101 | Patched domain-containing protein 3; May play a role in sperm development or sperm function | Ectoderm-neural cortex protein 1; Actin-binding protein involved in the regulation of neuronal process formation and in differentiation of neural crest cells. Down-regulates transcription factor NF2L2/NRF2 by decreasing the rate of protein synthesis and not via a ubiquitin- mediated proteasomal degradation mechanism; BTB domain containing | 0.716 |
| PTCHD3 | GPR85 | ENSP00000417658 | ENSP00000297146 | Patched domain-containing protein 3; May play a role in sperm development or sperm function | Probable G-protein coupled receptor 85; Orphan receptor; Belongs to the G-protein coupled receptor 1 family | 0.674 |
| PTCHD3 | IGSF9 | ENSP00000417658 | ENSP00000357073 | Patched domain-containing protein 3; May play a role in sperm development or sperm function | Protein turtle homolog A; Functions in dendrite outgrowth and synapse maturation; Belongs to the immunoglobulin superfamily. Turtle family | 0.723 |
