| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ATAD2B | BIVM | ENSP00000238789 | ENSP00000257336 | ATPase family, AAA domain containing 2B | Basic, immunoglobulin-like variable motif containing | 0.662 |
| ATAD2B | FAM199X | ENSP00000238789 | ENSP00000417581 | ATPase family, AAA domain containing 2B | Protein FAM199X; Family with sequence similarity 199, X-linked; Belongs to the FAM199 family | 0.551 |
| ATAD2B | INO80B | ENSP00000238789 | ENSP00000233331 | ATPase family, AAA domain containing 2B | INO80 complex subunit B; Induces growth and cell cycle arrests at the G1 phase of the cell cycle; INO80 complex | 0.567 |
| BIVM | ATAD2B | ENSP00000257336 | ENSP00000238789 | Basic, immunoglobulin-like variable motif containing | ATPase family, AAA domain containing 2B | 0.662 |
| BIVM | FAM199X | ENSP00000257336 | ENSP00000417581 | Basic, immunoglobulin-like variable motif containing | Protein FAM199X; Family with sequence similarity 199, X-linked; Belongs to the FAM199 family | 0.672 |
| BIVM | INO80B | ENSP00000257336 | ENSP00000233331 | Basic, immunoglobulin-like variable motif containing | INO80 complex subunit B; Induces growth and cell cycle arrests at the G1 phase of the cell cycle; INO80 complex | 0.680 |
| C17orf53 | FAM199X | ENSP00000313500 | ENSP00000417581 | Uncharacterized protein C17orf53; Chromosome 17 open reading frame 53 | Protein FAM199X; Family with sequence similarity 199, X-linked; Belongs to the FAM199 family | 0.641 |
| CSNK1D | CSNK1E | ENSP00000324464 | ENSP00000380044 | Casein kinase I isoform delta; Essential serine/threonine-protein kinase that regulates diverse cellular growth and survival processes including Wnt signaling, DNA repair and circadian rhythms. It can phosphorylate a large number of proteins. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Phosphorylates connexin-43/GJA1, MAP1A, SNAPIN, MAPT/TAU, TOP2A, DCK, HIF1A, EIF6, p53/TP53, DVL2, DVL3, ESR1, AIB1/NCOA3, DNMT1, PKD2, YAP1, PER1 and PER2. Central component of the circadian clock. In balance with PP1, dete [...] | Casein kinase I isoform epsilon; Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates DVL1 and DVL2. Central component of the circadian clock. In balance with PP1, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. Controls PER1 and PER2 nuclear transport and degradation. Inhibits cytokine-induced granuloytic differentiation | 0.981 |
| CSNK1D | FAM199X | ENSP00000324464 | ENSP00000417581 | Casein kinase I isoform delta; Essential serine/threonine-protein kinase that regulates diverse cellular growth and survival processes including Wnt signaling, DNA repair and circadian rhythms. It can phosphorylate a large number of proteins. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Phosphorylates connexin-43/GJA1, MAP1A, SNAPIN, MAPT/TAU, TOP2A, DCK, HIF1A, EIF6, p53/TP53, DVL2, DVL3, ESR1, AIB1/NCOA3, DNMT1, PKD2, YAP1, PER1 and PER2. Central component of the circadian clock. In balance with PP1, dete [...] | Protein FAM199X; Family with sequence similarity 199, X-linked; Belongs to the FAM199 family | 0.478 |
| CSNK1E | CSNK1D | ENSP00000380044 | ENSP00000324464 | Casein kinase I isoform epsilon; Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates DVL1 and DVL2. Central component of the circadian clock. In balance with PP1, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. Controls PER1 and PER2 nuclear transport and degradation. Inhibits cytokine-induced granuloytic differentiation | Casein kinase I isoform delta; Essential serine/threonine-protein kinase that regulates diverse cellular growth and survival processes including Wnt signaling, DNA repair and circadian rhythms. It can phosphorylate a large number of proteins. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Phosphorylates connexin-43/GJA1, MAP1A, SNAPIN, MAPT/TAU, TOP2A, DCK, HIF1A, EIF6, p53/TP53, DVL2, DVL3, ESR1, AIB1/NCOA3, DNMT1, PKD2, YAP1, PER1 and PER2. Central component of the circadian clock. In balance with PP1, dete [...] | 0.981 |
| CSNK1E | FAM199X | ENSP00000380044 | ENSP00000417581 | Casein kinase I isoform epsilon; Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates DVL1 and DVL2. Central component of the circadian clock. In balance with PP1, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. Controls PER1 and PER2 nuclear transport and degradation. Inhibits cytokine-induced granuloytic differentiation | Protein FAM199X; Family with sequence similarity 199, X-linked; Belongs to the FAM199 family | 0.566 |
| CSNK1E | WDR5 | ENSP00000380044 | ENSP00000351446 | Casein kinase I isoform epsilon; Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates DVL1 and DVL2. Central component of the circadian clock. In balance with PP1, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. Controls PER1 and PER2 nuclear transport and degradation. Inhibits cytokine-induced granuloytic differentiation | WD repeat-containing protein 5; Contributes to histone modification. May position the N- terminus of histone H3 for efficient trimethylation at ’Lys-4’. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at ’Lys-4’ of histone H3. H3 ’Lys-4’ methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation; Belongs to the WD repeat WDR5/wds family | 0.430 |
| FAM199X | ATAD2B | ENSP00000417581 | ENSP00000238789 | Protein FAM199X; Family with sequence similarity 199, X-linked; Belongs to the FAM199 family | ATPase family, AAA domain containing 2B | 0.551 |
| FAM199X | BIVM | ENSP00000417581 | ENSP00000257336 | Protein FAM199X; Family with sequence similarity 199, X-linked; Belongs to the FAM199 family | Basic, immunoglobulin-like variable motif containing | 0.672 |
| FAM199X | C17orf53 | ENSP00000417581 | ENSP00000313500 | Protein FAM199X; Family with sequence similarity 199, X-linked; Belongs to the FAM199 family | Uncharacterized protein C17orf53; Chromosome 17 open reading frame 53 | 0.641 |
| FAM199X | CSNK1D | ENSP00000417581 | ENSP00000324464 | Protein FAM199X; Family with sequence similarity 199, X-linked; Belongs to the FAM199 family | Casein kinase I isoform delta; Essential serine/threonine-protein kinase that regulates diverse cellular growth and survival processes including Wnt signaling, DNA repair and circadian rhythms. It can phosphorylate a large number of proteins. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Phosphorylates connexin-43/GJA1, MAP1A, SNAPIN, MAPT/TAU, TOP2A, DCK, HIF1A, EIF6, p53/TP53, DVL2, DVL3, ESR1, AIB1/NCOA3, DNMT1, PKD2, YAP1, PER1 and PER2. Central component of the circadian clock. In balance with PP1, dete [...] | 0.478 |
| FAM199X | CSNK1E | ENSP00000417581 | ENSP00000380044 | Protein FAM199X; Family with sequence similarity 199, X-linked; Belongs to the FAM199 family | Casein kinase I isoform epsilon; Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates DVL1 and DVL2. Central component of the circadian clock. In balance with PP1, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. Controls PER1 and PER2 nuclear transport and degradation. Inhibits cytokine-induced granuloytic differentiation | 0.566 |
| FAM199X | INO80B | ENSP00000417581 | ENSP00000233331 | Protein FAM199X; Family with sequence similarity 199, X-linked; Belongs to the FAM199 family | INO80 complex subunit B; Induces growth and cell cycle arrests at the G1 phase of the cell cycle; INO80 complex | 0.513 |
| FAM199X | MBIP | ENSP00000417581 | ENSP00000399718 | Protein FAM199X; Family with sequence similarity 199, X-linked; Belongs to the FAM199 family | MAP3K12-binding inhibitory protein 1; Inhibits the MAP3K12 activity to induce the activation of the JNK/SAPK pathway. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4 | 0.537 |
| FAM199X | PDPK1 | ENSP00000417581 | ENSP00000344220 | Protein FAM199X; Family with sequence similarity 199, X-linked; Belongs to the FAM199 family | 3-phosphoinositide-dependent protein kinase 1; Serine/threonine kinase which acts as a master kinase, phosphorylating and activating a subgroup of the AGC family of protein kinases. Its targets include- protein kinase B (PKB/AKT1, PKB/AKT2, PKB/AKT3), p70 ribosomal protein S6 kinase (RPS6KB1), p90 ribosomal protein S6 kinase (RPS6KA1, RPS6KA2 and RPS6KA3), cyclic AMP-dependent protein kinase (PRKACA), protein kinase C (PRKCD and PRKCZ), serum and glucocorticoid-inducible kinase (SGK1, SGK2 and SGK3), p21-activated kinase-1 (PAK1), protein kinase PKN (PKN1 and PKN2). Plays a central rol [...] | 0.864 |
