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STRINGSTRING
GDNF GDNF PDXK PDXK AADAT AADAT UCK2 UCK2 STXBP6 STXBP6 IAH1 IAH1 TACO1 TACO1 ADH1A ADH1A G2E3 G2E3 ABHD3 ABHD3 ABHD11 ABHD11
"IAH1" - Isoamyl acetate-hydrolyzing esterase 1 homolog in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Neighborhood
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[Homology]
Score
IAH1Isoamyl acetate-hydrolyzing esterase 1 homolog; Probable lipase (248 aa)    
Predicted Functional Partners:
UCK2
Uridine-cytidine kinase 2; Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate. Does not phosphorylate deoxyribonucleosides or purine ribonucleosides. Can use ATP or GTP as a phosphate donor. Can also phosphorylate cytidine and uridine nucleoside analogs such as 6-azauridine, 5-fluorouridine, 4- thiouridine, 5-bromouridine, N(4)-acetylcytidine, N(4)- benzoylcytidine, 5-fluorocytidine, 2-thiocytidine, 5- methylcytidine, and N(4)-anisoylcytidine; Belongs to the uridine kinase family (261 aa)
     
      0.690
ABHD3
Phospholipase ABHD3; Phospholipase that may play a role in phospholipids remodeling. May selectively cleave myristate (C14)-containing phosphatidylcholines through its predominant phospholipase 1 activity, cleaving preferentially acyl groups in sn1 position. In parallel, may have a minor phospholipase 2 activity acting on acyl groups in position sn2. In addition to (C14)-containing phosphatidylcholines, may also act on other medium-chain- containing and oxidatively truncated phospholipids; Abhydrolase domain containing (409 aa)
            
  0.665
G2E3
G2/M phase-specific E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Essential in early embryonic development to prevent apoptotic death; PHD finger proteins (706 aa)
            
  0.649
PDXK
Pyridoxal kinase; Required for synthesis of pyridoxal-5-phosphate from vitamin B6; Belongs to the pyridoxine kinase family (312 aa)
   
 
  0.541
AADAT
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial; Transaminase with broad substrate specificity. Has transaminase activity towards aminoadipate, kynurenine, methionine and glutamate. Shows activity also towards tryptophan, aspartate and hydroxykynurenine. Accepts a variety of oxo-acids as amino- group acceptors, with a preference for 2-oxoglutarate, 2- oxocaproic acid, phenylpyruvate and alpha-oxo-gamma-methiol butyric acid. Can also use glyoxylate as amino-group acceptor (in vitro) (429 aa)
         
  0.511
TACO1
Translational activator of cytochrome c oxidase 1; Acts as a translational activator of mitochondrially- encoded cytochrome c oxidase 1; Belongs to the TACO1 family (297 aa)
   
   
  0.501
ADH1A
Alcohol dehydrogenase 1A, alpha polypeptide; Belongs to the zinc-containing alcohol dehydrogenase family (375 aa)
        
 
  0.484
GDNF
Glial cell line-derived neurotrophic factor; Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake; Belongs to the TGF-beta family. GDNF subfamily (228 aa)
            
  0.482
ABHD11
Protein ABHD11; Abhydrolase domain containing 11; Belongs to the AB hydrolase superfamily (315 aa)
      
   
  0.468
STXBP6
Syntaxin-binding protein 6; Forms non-fusogenic complexes with SNAP25 and STX1A and may thereby modulate the formation of functional SNARE complexes and exocytosis (210 aa)
      
   
  0.462
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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