node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BBOX1 | FSD1L | ENSP00000263182 | ENSP00000417492 | Gamma-butyrobetaine dioxygenase; Catalyzes the formation of L-carnitine from gamma- butyrobetaine; Belongs to the gamma-BBH/TMLD family | FSD1-like protein; Fibronectin type III and SPRY domain containing 1 like | 0.489 |
EMR2 | FSD1L | ENSP00000319883 | ENSP00000417492 | Adhesion G protein-coupled receptor E2; Cell surface receptor that binds to the chondroitin sulfate moiety of glycosaminoglycan chains and promotes cell attachment. Promotes granulocyte chemotaxis, degranulation and adhesion. In macrophages, promotes the release of inflammatory cytokines, including IL8 and TNF. Signals probably through G- proteins. Is a regulator of mast cell degranulation; Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily | FSD1-like protein; Fibronectin type III and SPRY domain containing 1 like | 0.755 |
FAM179A | FSD1L | ENSP00000368876 | ENSP00000417492 | TOG array regulator of axonemal microtubules protein 2; Family with sequence similarity 179, member A | FSD1-like protein; Fibronectin type III and SPRY domain containing 1 like | 0.519 |
FAM179A | ZNF99 | ENSP00000368876 | ENSP00000472969 | TOG array regulator of axonemal microtubules protein 2; Family with sequence similarity 179, member A | Zinc finger protein 99; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.506 |
FN1 | FSD1L | ENSP00000346839 | ENSP00000417492 | Fibronectin type III domain containing; Endogenous ligands | FSD1-like protein; Fibronectin type III and SPRY domain containing 1 like | 0.470 |
FSD1L | BBOX1 | ENSP00000417492 | ENSP00000263182 | FSD1-like protein; Fibronectin type III and SPRY domain containing 1 like | Gamma-butyrobetaine dioxygenase; Catalyzes the formation of L-carnitine from gamma- butyrobetaine; Belongs to the gamma-BBH/TMLD family | 0.489 |
FSD1L | EMR2 | ENSP00000417492 | ENSP00000319883 | FSD1-like protein; Fibronectin type III and SPRY domain containing 1 like | Adhesion G protein-coupled receptor E2; Cell surface receptor that binds to the chondroitin sulfate moiety of glycosaminoglycan chains and promotes cell attachment. Promotes granulocyte chemotaxis, degranulation and adhesion. In macrophages, promotes the release of inflammatory cytokines, including IL8 and TNF. Signals probably through G- proteins. Is a regulator of mast cell degranulation; Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily | 0.755 |
FSD1L | FAM179A | ENSP00000417492 | ENSP00000368876 | FSD1-like protein; Fibronectin type III and SPRY domain containing 1 like | TOG array regulator of axonemal microtubules protein 2; Family with sequence similarity 179, member A | 0.519 |
FSD1L | FN1 | ENSP00000417492 | ENSP00000346839 | FSD1-like protein; Fibronectin type III and SPRY domain containing 1 like | Fibronectin type III domain containing; Endogenous ligands | 0.470 |
FSD1L | MADD | ENSP00000417492 | ENSP00000310933 | FSD1-like protein; Fibronectin type III and SPRY domain containing 1 like | MAP kinase-activating death domain protein; Plays a significant role in regulating cell proliferation, survival and death through alternative mRNA splicing. Isoform 5 shows increased cell proliferation and isoform 2 shows decreased. Converts GDP-bound inactive form of RAB3A, RAB3C and RAB3D to the GTP-bound active forms. Component of the TNFRSF1A signaling complex- MADD links TNFRSF1A with MAP kinase activation. Plays an important regulatory role in physiological cell death (TNF-alpha-induced, caspase-mediated apoptosis); isoform 1 is susceptible to inducing apoptosis, isoform 5 is res [...] | 0.484 |
FSD1L | MED12L | ENSP00000417492 | ENSP00000417235 | FSD1-like protein; Fibronectin type III and SPRY domain containing 1 like | Mediator of RNA polymerase II transcription subunit 12-like protein; May be a component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By [...] | 0.590 |
FSD1L | OBSL1 | ENSP00000417492 | ENSP00000385636 | FSD1-like protein; Fibronectin type III and SPRY domain containing 1 like | Obscurin-like protein 1; Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer. Acts as a regulator of the Cul7-RING(FBXW8) ubiquitin-protein ligase, playing a critical role in the ubiquitin ligase pathway that regulates Golgi morphogenesis and dendrite patterning in brain. Required to localize CUL7 to the Golgi apparatus in neurons; I-set domain containing | 0.516 |
FSD1L | SGPP2 | ENSP00000417492 | ENSP00000315137 | FSD1-like protein; Fibronectin type III and SPRY domain containing 1 like | Sphingosine-1-phosphate phosphatase 2; Has specific phosphohydrolase activity towards sphingoid base 1-phosphates. Has high phosphohydrolase activity against dihydrosphingosine-1-phosphate and sphingosine-1-phosphate (S1P) in vitro. May play a role in attenuating intracellular sphingosine 1-phosphate (S1P) signaling. May play a role in pro-inflammatory signaling | 0.493 |
FSD1L | TUBG1 | ENSP00000417492 | ENSP00000251413 | FSD1-like protein; Fibronectin type III and SPRY domain containing 1 like | Tubulin gamma-1 chain; Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. Pericentriolar matrix component that regulates alpha/beta chain minus-end nucleation, centrosome duplication and spindle formation; Tubulins | 0.538 |
FSD1L | ZNF99 | ENSP00000417492 | ENSP00000472969 | FSD1-like protein; Fibronectin type III and SPRY domain containing 1 like | Zinc finger protein 99; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.471 |
MADD | FSD1L | ENSP00000310933 | ENSP00000417492 | MAP kinase-activating death domain protein; Plays a significant role in regulating cell proliferation, survival and death through alternative mRNA splicing. Isoform 5 shows increased cell proliferation and isoform 2 shows decreased. Converts GDP-bound inactive form of RAB3A, RAB3C and RAB3D to the GTP-bound active forms. Component of the TNFRSF1A signaling complex- MADD links TNFRSF1A with MAP kinase activation. Plays an important regulatory role in physiological cell death (TNF-alpha-induced, caspase-mediated apoptosis); isoform 1 is susceptible to inducing apoptosis, isoform 5 is res [...] | FSD1-like protein; Fibronectin type III and SPRY domain containing 1 like | 0.484 |
MADD | MED12L | ENSP00000310933 | ENSP00000417235 | MAP kinase-activating death domain protein; Plays a significant role in regulating cell proliferation, survival and death through alternative mRNA splicing. Isoform 5 shows increased cell proliferation and isoform 2 shows decreased. Converts GDP-bound inactive form of RAB3A, RAB3C and RAB3D to the GTP-bound active forms. Component of the TNFRSF1A signaling complex- MADD links TNFRSF1A with MAP kinase activation. Plays an important regulatory role in physiological cell death (TNF-alpha-induced, caspase-mediated apoptosis); isoform 1 is susceptible to inducing apoptosis, isoform 5 is res [...] | Mediator of RNA polymerase II transcription subunit 12-like protein; May be a component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By [...] | 0.415 |
MED12L | FSD1L | ENSP00000417235 | ENSP00000417492 | Mediator of RNA polymerase II transcription subunit 12-like protein; May be a component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By [...] | FSD1-like protein; Fibronectin type III and SPRY domain containing 1 like | 0.590 |
MED12L | MADD | ENSP00000417235 | ENSP00000310933 | Mediator of RNA polymerase II transcription subunit 12-like protein; May be a component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By [...] | MAP kinase-activating death domain protein; Plays a significant role in regulating cell proliferation, survival and death through alternative mRNA splicing. Isoform 5 shows increased cell proliferation and isoform 2 shows decreased. Converts GDP-bound inactive form of RAB3A, RAB3C and RAB3D to the GTP-bound active forms. Component of the TNFRSF1A signaling complex- MADD links TNFRSF1A with MAP kinase activation. Plays an important regulatory role in physiological cell death (TNF-alpha-induced, caspase-mediated apoptosis); isoform 1 is susceptible to inducing apoptosis, isoform 5 is res [...] | 0.415 |
MED12L | OBSL1 | ENSP00000417235 | ENSP00000385636 | Mediator of RNA polymerase II transcription subunit 12-like protein; May be a component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By [...] | Obscurin-like protein 1; Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer. Acts as a regulator of the Cul7-RING(FBXW8) ubiquitin-protein ligase, playing a critical role in the ubiquitin ligase pathway that regulates Golgi morphogenesis and dendrite patterning in brain. Required to localize CUL7 to the Golgi apparatus in neurons; I-set domain containing | 0.402 |