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STRINGSTRING
COG3 COG3 COG6 COG6 COG7 COG7 COG8 COG8 COG4 COG4 GOLIM4 GOLIM4 GOSR1 GOSR1 GOLGA5 GOLGA5 COG1 COG1 COG5 COG5 STX5 STX5
"GOLIM4" - Golgi integral membrane protein 4 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
GOLIM4Golgi integral membrane protein 4; Plays a role in endosome to Golgi protein trafficking; mediates protein transport along the late endosome-bypass pathway from the early endosome to the Golgi (696 aa)    
Predicted Functional Partners:
STX5
Syntaxin-5; Mediates endoplasmic reticulum to Golgi transport. Together with p115/USO1 and GM130/GOLGA2, involved in vesicle tethering and fusion at the cis-Golgi membrane to maintain the stacked and inter-connected structure of the Golgi apparatus; Syntaxins (355 aa)
          
  0.957
GOLGA5
Golgin subfamily A member 5; Involved in maintaining Golgi structure. Stimulates the formation of Golgi stacks and ribbons. Involved in intra-Golgi retrograde transport (731 aa)
          
  0.956
COG4
Conserved oligomeric Golgi complex subunit 4; Required for normal Golgi function. Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with SCFD1; Belongs to the COG4 family (789 aa)
          
  0.954
GOSR1
Golgi SNAP receptor complex member 1; Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide- sensitive factor) attachment protein receptor. May play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14). Participates in docking and fusion stage of ER to cis-Golgi transport. Plays an impor [...] (250 aa)
          
  0.954
COG3
Conserved oligomeric Golgi complex subunit 3; Involved in ER-Golgi transport; Belongs to the COG3 family (828 aa)
          
  0.953
COG8
Conserved oligomeric Golgi complex subunit 8; Required for normal Golgi function; Components of oligomeric golgi complex (612 aa)
          
  0.950
COG6
Conserved oligomeric Golgi complex subunit 6; Required for normal Golgi function; Components of oligomeric golgi complex (657 aa)
          
  0.950
COG1
Conserved oligomeric Golgi complex subunit 1; Required for normal Golgi function; Components of oligomeric golgi complex (980 aa)
          
  0.947
COG7
Conserved oligomeric Golgi complex subunit 7; Required for normal Golgi function; Components of oligomeric golgi complex (770 aa)
          
  0.942
COG5
Conserved oligomeric Golgi complex subunit 5; Required for normal Golgi function; Belongs to the COG5 family (860 aa)
          
  0.941
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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