EBP protein (human) - STRING database

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EBP

3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase; Catalyzes the conversion of Delta(8)-sterols to their corresponding Delta(7)-isomers; Belongs to the EBP family (230 aa)

Predicted Functional Partners:

SC5D

0.981

TM7SF2

0.972

DHCR24

0.956

HSD17B7

0.948

NSDHL

0.935

DHCR7

0.835

DST

0.715

ARSE

0.711

MSMO1

0.678

ACAT2

0.666

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACAT2	DHCR24	ENSP00000356015	ENSP00000360316	Acetyl-CoA acetyltransferase, cytosolic; acetyl-CoA acetyltransferase 2	Delta(24)-sterol reductase; Catalyzes the reduction of the delta-24 double bond of sterol intermediates. Protects cells from oxidative stress by reducing caspase 3 activity during apoptosis induced by oxidative stress. Also protects against amyloid-beta peptide-induced apoptosis; Belongs to the FAD-binding oxidoreductase/transferase type 4 family	0.432
ACAT2	DHCR7	ENSP00000356015	ENSP00000347717	Acetyl-CoA acetyltransferase, cytosolic; acetyl-CoA acetyltransferase 2	7-dehydrocholesterol reductase; Production of cholesterol by reduction of C7-C8 double bond of 7-dehydrocholesterol (7-DHC); Belongs to the ERG4/ERG24 family	0.761
ACAT2	EBP	ENSP00000356015	ENSP00000417052	Acetyl-CoA acetyltransferase, cytosolic; acetyl-CoA acetyltransferase 2	3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase; Catalyzes the conversion of Delta(8)-sterols to their corresponding Delta(7)-isomers; Belongs to the EBP family	0.666
ACAT2	HSD17B7	ENSP00000356015	ENSP00000254521	Acetyl-CoA acetyltransferase, cytosolic; acetyl-CoA acetyltransferase 2	3-keto-steroid reductase; Responsible for the reduction of the keto group on the C-3 of sterols; Short chain dehydrogenase/reductase superfamily	0.554
ACAT2	MSMO1	ENSP00000356015	ENSP00000261507	Acetyl-CoA acetyltransferase, cytosolic; acetyl-CoA acetyltransferase 2	Methylsterol monooxygenase 1; Catalyzes the first step in the removal of the two C-4 methyl groups of 4,4-dimethylzymosterol; Belongs to the sterol desaturase family	0.691
ACAT2	NSDHL	ENSP00000356015	ENSP00000359297	Acetyl-CoA acetyltransferase, cytosolic; acetyl-CoA acetyltransferase 2	Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating; Involved in the sequential removal of two C-4 methyl groups in post-squalene cholesterol biosynthesis; Short chain dehydrogenase/reductase superfamily	0.668
ACAT2	SC5D	ENSP00000356015	ENSP00000264027	Acetyl-CoA acetyltransferase, cytosolic; acetyl-CoA acetyltransferase 2	Lathosterol oxidase; Catalyzes a dehydrogenation to introduce C5-6 double bond into lathosterol; Belongs to the sterol desaturase family	0.617
ACAT2	TM7SF2	ENSP00000356015	ENSP00000279263	Acetyl-CoA acetyltransferase, cytosolic; acetyl-CoA acetyltransferase 2	Delta(14)-sterol reductase; Involved in the conversion of lanosterol to cholesterol	0.545
ARSE	DST	ENSP00000441417	ENSP00000307959	Arylsulfatase E; May be essential for the correct composition of cartilage and bone matrix during development. Has no activity toward steroid sulfates; Sulfatases	Dystonin; Cytoskeletal linker protein. Acts as an integrator of intermediate filaments, actin and microtubule cytoskeleton networks. Required for anchoring either intermediate filaments to the actin cytoskeleton in neural and muscle cells or keratin- containing intermediate filaments to hemidesmosomes in epithelial cells. The proteins may self-aggregate to form filaments or a two- dimensional mesh. Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport. Mediates docking of the dynein/dynactin motor complex to vesicle cargos for [...]	0.488
ARSE	EBP	ENSP00000441417	ENSP00000417052	Arylsulfatase E; May be essential for the correct composition of cartilage and bone matrix during development. Has no activity toward steroid sulfates; Sulfatases	3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase; Catalyzes the conversion of Delta(8)-sterols to their corresponding Delta(7)-isomers; Belongs to the EBP family	0.711
DHCR24	ACAT2	ENSP00000360316	ENSP00000356015	Delta(24)-sterol reductase; Catalyzes the reduction of the delta-24 double bond of sterol intermediates. Protects cells from oxidative stress by reducing caspase 3 activity during apoptosis induced by oxidative stress. Also protects against amyloid-beta peptide-induced apoptosis; Belongs to the FAD-binding oxidoreductase/transferase type 4 family	Acetyl-CoA acetyltransferase, cytosolic; acetyl-CoA acetyltransferase 2	0.432
DHCR24	DHCR7	ENSP00000360316	ENSP00000347717	Delta(24)-sterol reductase; Catalyzes the reduction of the delta-24 double bond of sterol intermediates. Protects cells from oxidative stress by reducing caspase 3 activity during apoptosis induced by oxidative stress. Also protects against amyloid-beta peptide-induced apoptosis; Belongs to the FAD-binding oxidoreductase/transferase type 4 family	7-dehydrocholesterol reductase; Production of cholesterol by reduction of C7-C8 double bond of 7-dehydrocholesterol (7-DHC); Belongs to the ERG4/ERG24 family	0.988
DHCR24	EBP	ENSP00000360316	ENSP00000417052	Delta(24)-sterol reductase; Catalyzes the reduction of the delta-24 double bond of sterol intermediates. Protects cells from oxidative stress by reducing caspase 3 activity during apoptosis induced by oxidative stress. Also protects against amyloid-beta peptide-induced apoptosis; Belongs to the FAD-binding oxidoreductase/transferase type 4 family	3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase; Catalyzes the conversion of Delta(8)-sterols to their corresponding Delta(7)-isomers; Belongs to the EBP family	0.956
DHCR24	HSD17B7	ENSP00000360316	ENSP00000254521	Delta(24)-sterol reductase; Catalyzes the reduction of the delta-24 double bond of sterol intermediates. Protects cells from oxidative stress by reducing caspase 3 activity during apoptosis induced by oxidative stress. Also protects against amyloid-beta peptide-induced apoptosis; Belongs to the FAD-binding oxidoreductase/transferase type 4 family	3-keto-steroid reductase; Responsible for the reduction of the keto group on the C-3 of sterols; Short chain dehydrogenase/reductase superfamily	0.683
DHCR24	MSMO1	ENSP00000360316	ENSP00000261507	Delta(24)-sterol reductase; Catalyzes the reduction of the delta-24 double bond of sterol intermediates. Protects cells from oxidative stress by reducing caspase 3 activity during apoptosis induced by oxidative stress. Also protects against amyloid-beta peptide-induced apoptosis; Belongs to the FAD-binding oxidoreductase/transferase type 4 family	Methylsterol monooxygenase 1; Catalyzes the first step in the removal of the two C-4 methyl groups of 4,4-dimethylzymosterol; Belongs to the sterol desaturase family	0.972
DHCR24	NSDHL	ENSP00000360316	ENSP00000359297	Delta(24)-sterol reductase; Catalyzes the reduction of the delta-24 double bond of sterol intermediates. Protects cells from oxidative stress by reducing caspase 3 activity during apoptosis induced by oxidative stress. Also protects against amyloid-beta peptide-induced apoptosis; Belongs to the FAD-binding oxidoreductase/transferase type 4 family	Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating; Involved in the sequential removal of two C-4 methyl groups in post-squalene cholesterol biosynthesis; Short chain dehydrogenase/reductase superfamily	0.779
DHCR24	SC5D	ENSP00000360316	ENSP00000264027	Delta(24)-sterol reductase; Catalyzes the reduction of the delta-24 double bond of sterol intermediates. Protects cells from oxidative stress by reducing caspase 3 activity during apoptosis induced by oxidative stress. Also protects against amyloid-beta peptide-induced apoptosis; Belongs to the FAD-binding oxidoreductase/transferase type 4 family	Lathosterol oxidase; Catalyzes a dehydrogenation to introduce C5-6 double bond into lathosterol; Belongs to the sterol desaturase family	0.977
DHCR24	TM7SF2	ENSP00000360316	ENSP00000279263	Delta(24)-sterol reductase; Catalyzes the reduction of the delta-24 double bond of sterol intermediates. Protects cells from oxidative stress by reducing caspase 3 activity during apoptosis induced by oxidative stress. Also protects against amyloid-beta peptide-induced apoptosis; Belongs to the FAD-binding oxidoreductase/transferase type 4 family	Delta(14)-sterol reductase; Involved in the conversion of lanosterol to cholesterol	0.972
DHCR7	ACAT2	ENSP00000347717	ENSP00000356015	7-dehydrocholesterol reductase; Production of cholesterol by reduction of C7-C8 double bond of 7-dehydrocholesterol (7-DHC); Belongs to the ERG4/ERG24 family	Acetyl-CoA acetyltransferase, cytosolic; acetyl-CoA acetyltransferase 2	0.761
DHCR7	DHCR24	ENSP00000347717	ENSP00000360316	7-dehydrocholesterol reductase; Production of cholesterol by reduction of C7-C8 double bond of 7-dehydrocholesterol (7-DHC); Belongs to the ERG4/ERG24 family	Delta(24)-sterol reductase; Catalyzes the reduction of the delta-24 double bond of sterol intermediates. Protects cells from oxidative stress by reducing caspase 3 activity during apoptosis induced by oxidative stress. Also protects against amyloid-beta peptide-induced apoptosis; Belongs to the FAD-binding oxidoreductase/transferase type 4 family	0.988

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