PLEKHM3 protein (human) - STRING database

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PLEKHM3

Pleckstrin homology domain containing M3 (761 aa)

Predicted Functional Partners:

AHNAK

0.669

CCNYL1

0.653

KLF7

0.650

DEF8

0.649

ANKRD54

0.625

CDAN1

0.586

PIKFYVE

0.571

IDH1

0.556

LIAS

0.547

DOCK10

0.544

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AHNAK	PLEKHM3	ENSP00000367263	ENSP00000417003	Neuroblast differentiation-associated protein AHNAK; May be required for neuronal cell differentiation; PDZ domain containing	Pleckstrin homology domain containing M3	0.669
ANKRD54	CDAN1	ENSP00000215941	ENSP00000348564	Ankyrin repeat domain-containing protein 54; Plays an important role in regulating intracellular signaling events associated with erythroid terminal differentiation; Ankyrin repeat domain containing	Codanin-1; May act as a negative regulator of ASF1 in chromatin assembly	0.400
ANKRD54	LIAS	ENSP00000215941	ENSP00000261434	Ankyrin repeat domain-containing protein 54; Plays an important role in regulating intracellular signaling events associated with erythroid terminal differentiation; Ankyrin repeat domain containing	Lipoyl synthase, mitochondrial; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives	0.793
ANKRD54	PLEKHM3	ENSP00000215941	ENSP00000417003	Ankyrin repeat domain-containing protein 54; Plays an important role in regulating intracellular signaling events associated with erythroid terminal differentiation; Ankyrin repeat domain containing	Pleckstrin homology domain containing M3	0.625
CCNYL1	KLF7	ENSP00000342344	ENSP00000309570	Cyclin-Y-like protein 1; Cyclin Y like 1; Belongs to the cyclin family	Krueppel-like factor 7; Transcriptional activator. Binds in vitro to the CACCC motif of the beta-globin promoter and to the SP1 recognition sequence; Kruppel like factors	0.493
CCNYL1	PLEKHM3	ENSP00000342344	ENSP00000417003	Cyclin-Y-like protein 1; Cyclin Y like 1; Belongs to the cyclin family	Pleckstrin homology domain containing M3	0.653
CDAN1	ANKRD54	ENSP00000348564	ENSP00000215941	Codanin-1; May act as a negative regulator of ASF1 in chromatin assembly	Ankyrin repeat domain-containing protein 54; Plays an important role in regulating intracellular signaling events associated with erythroid terminal differentiation; Ankyrin repeat domain containing	0.400
CDAN1	PLEKHM3	ENSP00000348564	ENSP00000417003	Codanin-1; May act as a negative regulator of ASF1 in chromatin assembly	Pleckstrin homology domain containing M3	0.586
DEF8	PLEKHM3	ENSP00000268676	ENSP00000417003	Differentially expressed in FDCP 8 homolog; Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts. Involved in bone resorption	Pleckstrin homology domain containing M3	0.649
DOCK10	PLEKHM3	ENSP00000258390	ENSP00000417003	Dedicator of cytokinesis protein 10; Guanine nucleotide-exchange factor (GEF) that activates CDC42 and RAC1 by exchanging bound GDP for free GTP. Essential for dendritic spine morphogenesis in Purkinje cells and in hippocampal neurons, via a CDC42-mediated pathway. Sustains B-cell lymphopoiesis in secondary lymphoid tissues and regulates FCER2/CD23 expression; Belongs to the DOCK family	Pleckstrin homology domain containing M3	0.544
IDH1	PIKFYVE	ENSP00000390265	ENSP00000264380	Isocitrate dehydrogenase 1, cytosolic	1-phosphatidylinositol 3-phosphate 5-kinase; The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Catalyzes the phosphorylation of phosphatidylinositol 3-phosphate on the fifth hydroxyl of the myo- inositol ring, to form phosphatidylinositol 3,5-bisphosphate. Required for endocytic-vacuolar pathway and nuclear migration. Plays a role in the biogenesis of endosome carrier vesicles (ECV)/ multivesicular bodies (MVB) transport intermediates from early endosomes; Zinc fingers FYVE-type	0.470
IDH1	PLEKHM3	ENSP00000390265	ENSP00000417003	Isocitrate dehydrogenase 1, cytosolic	Pleckstrin homology domain containing M3	0.556
KLF7	CCNYL1	ENSP00000309570	ENSP00000342344	Krueppel-like factor 7; Transcriptional activator. Binds in vitro to the CACCC motif of the beta-globin promoter and to the SP1 recognition sequence; Kruppel like factors	Cyclin-Y-like protein 1; Cyclin Y like 1; Belongs to the cyclin family	0.493
KLF7	PLEKHM3	ENSP00000309570	ENSP00000417003	Krueppel-like factor 7; Transcriptional activator. Binds in vitro to the CACCC motif of the beta-globin promoter and to the SP1 recognition sequence; Kruppel like factors	Pleckstrin homology domain containing M3	0.650
LIAS	ANKRD54	ENSP00000261434	ENSP00000215941	Lipoyl synthase, mitochondrial; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives	Ankyrin repeat domain-containing protein 54; Plays an important role in regulating intracellular signaling events associated with erythroid terminal differentiation; Ankyrin repeat domain containing	0.793
LIAS	PLEKHM3	ENSP00000261434	ENSP00000417003	Lipoyl synthase, mitochondrial; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives	Pleckstrin homology domain containing M3	0.547
PIKFYVE	IDH1	ENSP00000264380	ENSP00000390265	1-phosphatidylinositol 3-phosphate 5-kinase; The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Catalyzes the phosphorylation of phosphatidylinositol 3-phosphate on the fifth hydroxyl of the myo- inositol ring, to form phosphatidylinositol 3,5-bisphosphate. Required for endocytic-vacuolar pathway and nuclear migration. Plays a role in the biogenesis of endosome carrier vesicles (ECV)/ multivesicular bodies (MVB) transport intermediates from early endosomes; Zinc fingers FYVE-type	Isocitrate dehydrogenase 1, cytosolic	0.470
PIKFYVE	PLEKHM3	ENSP00000264380	ENSP00000417003	1-phosphatidylinositol 3-phosphate 5-kinase; The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Catalyzes the phosphorylation of phosphatidylinositol 3-phosphate on the fifth hydroxyl of the myo- inositol ring, to form phosphatidylinositol 3,5-bisphosphate. Required for endocytic-vacuolar pathway and nuclear migration. Plays a role in the biogenesis of endosome carrier vesicles (ECV)/ multivesicular bodies (MVB) transport intermediates from early endosomes; Zinc fingers FYVE-type	Pleckstrin homology domain containing M3	0.571
PLEKHM3	AHNAK	ENSP00000417003	ENSP00000367263	Pleckstrin homology domain containing M3	Neuroblast differentiation-associated protein AHNAK; May be required for neuronal cell differentiation; PDZ domain containing	0.669
PLEKHM3	ANKRD54	ENSP00000417003	ENSP00000215941	Pleckstrin homology domain containing M3	Ankyrin repeat domain-containing protein 54; Plays an important role in regulating intracellular signaling events associated with erythroid terminal differentiation; Ankyrin repeat domain containing	0.625

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