| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AMBN | AMELX | ENSP00000313809 | ENSP00000370088 | Ameloblastin; Involved in the mineralization and structural organization of enamel; Belongs to the ameloblastin family | Amelogenin, X isoform; Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel; Belongs to the amelogenin family | 0.995 |
| AMBN | AMTN | ENSP00000313809 | ENSP00000341013 | Ameloblastin; Involved in the mineralization and structural organization of enamel; Belongs to the ameloblastin family | Amelotin; Is a promoter of calcium phosphate mineralization, playing a critical role in the formation of the compact, mineralized, aprismatic enamel surface layer during the maturation stage of amelogenesis | 0.987 |
| AMBN | DMP1 | ENSP00000313809 | ENSP00000340935 | Ameloblastin; Involved in the mineralization and structural organization of enamel; Belongs to the ameloblastin family | Dentin matrix acidic phosphoprotein 1; May have a dual function during osteoblast differentiation. In the nucleus of undifferentiated osteoblasts, unphosphorylated form acts as a transcriptional component for activation of osteoblast-specific genes like osteocalcin. During the osteoblast to osteocyte transition phase it is phosphorylated and exported into the extracellular matrix, where it regulates nucleation of hydroxyapatite; SIBLING family | 0.951 |
| AMBN | ENAM | ENSP00000313809 | ENSP00000379383 | Ameloblastin; Involved in the mineralization and structural organization of enamel; Belongs to the ameloblastin family | Enamelin; Involved in the mineralization and structural organization of enamel. Involved in the extension of enamel during the secretory stage of dental enamel formation | 0.992 |
| AMBN | FAM20C | ENSP00000313809 | ENSP00000322323 | Ameloblastin; Involved in the mineralization and structural organization of enamel; Belongs to the ameloblastin family | Extracellular serine/threonine protein kinase FAM20C; Golgi serine/threonine protein kinase that phosphorylates secretory pathway proteins within Ser-x-Glu/pSer motifs and plays a key role in biomineralization of bones and teeth. Constitutes the main protein kinase for extracellular proteins, generating the majority of the extracellular phosphoproteome. Mainly phosphorylates proteins within the Ser- x-Glu/pSer motif, but also displays a broader substrate specificity. Phosphorylates casein as well as a number of proteins involved in biomineralization such as AMELX, AMTN, ENAM and SPP1. [...] | 0.971 |
| AMBN | FGF23 | ENSP00000313809 | ENSP00000237837 | Ameloblastin; Involved in the mineralization and structural organization of enamel; Belongs to the ameloblastin family | Fibroblast growth factor 23; Regulator of phosphate homeostasis. Inhibits renal tubular phosphate transport by reducing SLC34A1 levels. Upregulates EGR1 expression in the presence of KL (By similarity). Acts directly on the parathyroid to decrease PTH secretion (By similarity). Regulator of vitamin-D metabolism. Negatively regulates osteoblast differentiation and matrix mineralization | 0.912 |
| AMBN | FN1 | ENSP00000313809 | ENSP00000346839 | Ameloblastin; Involved in the mineralization and structural organization of enamel; Belongs to the ameloblastin family | Fibronectin type III domain containing; Endogenous ligands | 0.923 |
| AMBN | MEPE | ENSP00000313809 | ENSP00000416984 | Ameloblastin; Involved in the mineralization and structural organization of enamel; Belongs to the ameloblastin family | Matrix extracellular phosphoglycoprotein; Promotes renal phosphate excretion and modulates mineralization; SIBLING family | 0.951 |
| AMBN | SPARCL1 | ENSP00000313809 | ENSP00000414856 | Ameloblastin; Involved in the mineralization and structural organization of enamel; Belongs to the ameloblastin family | SPARC-like protein 1; SPARC family | 0.972 |
| AMBN | SPP1 | ENSP00000313809 | ENSP00000378517 | Ameloblastin; Involved in the mineralization and structural organization of enamel; Belongs to the ameloblastin family | Osteopontin; Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction; Endogenous ligands | 0.943 |
| AMELX | AMBN | ENSP00000370088 | ENSP00000313809 | Amelogenin, X isoform; Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel; Belongs to the amelogenin family | Ameloblastin; Involved in the mineralization and structural organization of enamel; Belongs to the ameloblastin family | 0.995 |
| AMELX | AMTN | ENSP00000370088 | ENSP00000341013 | Amelogenin, X isoform; Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel; Belongs to the amelogenin family | Amelotin; Is a promoter of calcium phosphate mineralization, playing a critical role in the formation of the compact, mineralized, aprismatic enamel surface layer during the maturation stage of amelogenesis | 0.982 |
| AMELX | DMP1 | ENSP00000370088 | ENSP00000340935 | Amelogenin, X isoform; Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel; Belongs to the amelogenin family | Dentin matrix acidic phosphoprotein 1; May have a dual function during osteoblast differentiation. In the nucleus of undifferentiated osteoblasts, unphosphorylated form acts as a transcriptional component for activation of osteoblast-specific genes like osteocalcin. During the osteoblast to osteocyte transition phase it is phosphorylated and exported into the extracellular matrix, where it regulates nucleation of hydroxyapatite; SIBLING family | 0.938 |
| AMELX | ENAM | ENSP00000370088 | ENSP00000379383 | Amelogenin, X isoform; Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel; Belongs to the amelogenin family | Enamelin; Involved in the mineralization and structural organization of enamel. Involved in the extension of enamel during the secretory stage of dental enamel formation | 0.995 |
| AMELX | FAM20C | ENSP00000370088 | ENSP00000322323 | Amelogenin, X isoform; Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel; Belongs to the amelogenin family | Extracellular serine/threonine protein kinase FAM20C; Golgi serine/threonine protein kinase that phosphorylates secretory pathway proteins within Ser-x-Glu/pSer motifs and plays a key role in biomineralization of bones and teeth. Constitutes the main protein kinase for extracellular proteins, generating the majority of the extracellular phosphoproteome. Mainly phosphorylates proteins within the Ser- x-Glu/pSer motif, but also displays a broader substrate specificity. Phosphorylates casein as well as a number of proteins involved in biomineralization such as AMELX, AMTN, ENAM and SPP1. [...] | 0.974 |
| AMELX | FGF23 | ENSP00000370088 | ENSP00000237837 | Amelogenin, X isoform; Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel; Belongs to the amelogenin family | Fibroblast growth factor 23; Regulator of phosphate homeostasis. Inhibits renal tubular phosphate transport by reducing SLC34A1 levels. Upregulates EGR1 expression in the presence of KL (By similarity). Acts directly on the parathyroid to decrease PTH secretion (By similarity). Regulator of vitamin-D metabolism. Negatively regulates osteoblast differentiation and matrix mineralization | 0.905 |
| AMELX | FN1 | ENSP00000370088 | ENSP00000346839 | Amelogenin, X isoform; Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel; Belongs to the amelogenin family | Fibronectin type III domain containing; Endogenous ligands | 0.927 |
| AMELX | MEPE | ENSP00000370088 | ENSP00000416984 | Amelogenin, X isoform; Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel; Belongs to the amelogenin family | Matrix extracellular phosphoglycoprotein; Promotes renal phosphate excretion and modulates mineralization; SIBLING family | 0.941 |
| AMELX | SPARCL1 | ENSP00000370088 | ENSP00000414856 | Amelogenin, X isoform; Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel; Belongs to the amelogenin family | SPARC-like protein 1; SPARC family | 0.940 |
| AMELX | SPP1 | ENSP00000370088 | ENSP00000378517 | Amelogenin, X isoform; Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel; Belongs to the amelogenin family | Osteopontin; Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction; Endogenous ligands | 0.945 |
