• Version:
  • 11.0 [archived version]
STRINGSTRING
PSMG1 PSMG1 LCA5 LCA5 CCM2 CCM2 B3GALT5 B3GALT5 WRB WRB XKR6 XKR6 FAM167A FAM167A C2orf16 C2orf16 BRWD1 BRWD1 ZNF512 ZNF512 FNDC4 FNDC4
"XKR6" - XK-related protein 6 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
XKR6XK-related protein 6; XK related family; Belongs to the XK family (641 aa)    
Predicted Functional Partners:
FAM167A
Protein FAM167A; Family with sequence similarity 167 member A; Belongs to the FAM167 (SEC) family (214 aa)
           
  0.860
FNDC4
Fibronectin type III domain-containing protein 4; Acts as an anti-inflammatory factor in the intestine and colon. Binds to and acts on macrophages to downregulate pro- inflammatory gene expression. Affects key macrophage functions, including phagocytosis, by downregulating many key pathways for macrophage activation, partly via by STAT3 activation and signaling. May be required to dampen the immunological response in colitis; Fibronectin type III domain containing (234 aa)
           
  0.730
PSMG1
Proteasome assembly chaperone 1; Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG2. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization (288 aa)
           
  0.703
B3GALT5
Beta-1,3-galactosyltransferase 5; Catalyzes the transfer of Gal to GlcNAc-based acceptors with a preference for the core3 O-linked glycan GlcNAc(beta1,3)GalNAc structure. Can use glycolipid LC3Cer as an efficient acceptor; Belongs to the glycosyltransferase 31 family (314 aa)
           
  0.698
BRWD1
Bromodomain and WD repeat-containing protein 1; May be a transcriptional activator. May be involved in chromatin remodeling (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape; Bromodomain containing (2320 aa)
           
  0.693
LCA5
Lebercilin; Might be involved in minus end-directed microtubule transport (697 aa)
           
  0.687
WRB
Tail-anchored protein insertion receptor WRB; Receptor for ASNA1/TRC40-mediated insertion of tail- anchored (TA) proteins into the ER membrane; Belongs to the WRB/GET1 family (174 aa)
           
  0.686
CCM2
Cerebral cavernous malformations 2 protein; Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. May act through the stabilization of endothelial cell junctions (By similarity). May function as a scaffold protein for MAP2K3-MAP3K3 signaling. Seems to play a major role in the modulation of MAP3K3- dependent p38 activation induced by hyperosmotic shock (By similarity) (465 aa)
           
  0.674
C2orf16
Uncharacterized protein C2orf16; Chromosome 2 open reading frame 16 (1984 aa)
           
  0.658
ZNF512
Zinc finger protein 512; May be involved in transcriptional regulation; Zinc fingers C2H2-type (567 aa)
           
  0.650
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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