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STRINGSTRING
POMC POMC TSHR TSHR TSHB TSHB GPHA2 GPHA2 LHCGR LHCGR FSHR FSHR GHRHR GHRHR CGA CGA FSHB FSHB INHBB INHBB INHA INHA
"FSHB" - Follitropin subunit beta in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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FSHBFollitropin subunit beta; Stimulates development of follicle and spermatogenesis in the reproductive organs; Belongs to the glycoprotein hormones subunit beta family (129 aa)    
Predicted Functional Partners:
FSHR
Follicle-stimulating hormone receptor; Receptor for follicle-stimulating hormone or follitropin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Induces cAMP production through the activation of PI3K-AKT and SRC-ERK1/2 signaling pathways; Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily (695 aa)
        
  0.995
CGA
Glycoprotein hormones, alpha polypeptide; Belongs to the glycoprotein hormones subunit alpha family (147 aa)
      
  0.988
TSHR
Thyrotropin receptor; Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2-GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism (By similarity); Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily (764 aa)
          
  0.965
GHRHR
Growth hormone-releasing hormone receptor; Receptor for GRF, coupled to G proteins which activate adenylyl cyclase. Stimulates somatotroph cell growth, growth hormone gene transcription and growth hormone secretion; Belongs to the G-protein coupled receptor 2 family (423 aa)
      
 
  0.955
LHCGR
Lutropin-choriogonadotropic hormone receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Glycoprotein hormone receptors (699 aa)
          
  0.954
TSHB
Thyrotropin subunit beta; Indispensable for the control of thyroid structure and metabolism; Endogenous ligands (138 aa)
      
 
0.952
POMC
Pro-opiomelanocortin; Met-enkephalin- Endogenous opiate; Belongs to the POMC family (267 aa)
      
 
  0.951
GPHA2
Glycoprotein hormone alpha-2; Functions as a heterodimeric glycoprotein hormone with GPHB5 able to bind and activate the thyroid-stimulating hormone receptor (TSHR), leading to increased cAMP production. Plays a central role in controlling thyroid cell metabolism; Belongs to the glycoprotein hormones subunit alpha family (129 aa)
        
  0.944
INHA
Inhibin alpha chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins; Belongs to the TGF-beta family (366 aa)
          
  0.938
INHBB
Inhibin beta B chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins; Endogenous ligands (407 aa)
          
  0.938
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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