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STRINGSTRING
SKP1 SKP1 FBXL19 FBXL19 CUL1 CUL1 NYAP2 NYAP2 FBXO24 FBXO24 ANKRD46 ANKRD46 CARS CARS ACAP1 ACAP1 ANKRD10 ANKRD10 RNF214 RNF214 NYAP1 NYAP1
"FBXO24" - F-box only protein 24 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
FBXO24F-box only protein 24; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex; F-boxes other (618 aa)    
Predicted Functional Partners:
SKP1
S-phase kinase-associated protein 1; Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC [...] (163 aa)
        
 
  0.802
ANKRD46
Ankyrin repeat domain-containing protein 46; Ankyrin repeat domain containing (232 aa)
      
 
  0.780
CUL1
Cullin-1; Core component of multiple cullin-RING-based SCF (SKP1- CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. SCF complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins. In the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin- protein ligase activity of the [...] (776 aa)
      
 
  0.778
ANKRD10
Ankyrin repeat domain-containing protein 10; Ankyrin repeat domain containing (420 aa)
        
 
  0.755
RNF214
Ring finger protein 214 (703 aa)
            
  0.745
NYAP2
Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2; Activates PI3K and concomitantly recruits the WAVE1 complex to the close vicinity of PI3K and regulates neuronal morphogenesis (653 aa)
            
  0.739
FBXL19
F-box/LRR-repeat protein 19; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex; F-box and leucine rich repeat proteins (694 aa)
      
 
  0.728
ACAP1
Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1; GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6) required for clathrin-dependent export of proteins from recycling endosomes to trans-Golgi network and cell surface. Required for regulated export of ITGB1 from recycling endosomes to the cell surface and ITGB1-dependent cell migration; Ankyrin repeat domain containing (740 aa)
      
   
  0.694
NYAP1
Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 1; Activates PI3K and concomitantly recruits the WAVE1 complex to the close vicinity of PI3K and regulates neuronal morphogenesis; Belongs to the NYAP family (841 aa)
            
  0.666
CARS
Cysteine--tRNA ligase, cytoplasmic; Aminoacyl tRNA synthetases, Class I; Belongs to the class-I aminoacyl-tRNA synthetase family (831 aa)
            
  0.660
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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