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STRINGSTRING
EIF2S3L EIF2S3L EIF2B5 EIF2B5 RD3 RD3 EIF2S2 EIF2S2 EIF2B1 EIF2B1 EIF2S1 EIF2S1 EIF2B3 EIF2B3 EIF2B4 EIF2B4 EIF2B2 EIF2B2 EIF2AK4 EIF2AK4 EIF2S3 EIF2S3
"EIF2B1" - Translation initiation factor eIF-2B subunit alpha in Homo sapiens
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second shell of interactors
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experimentally determined
Predicted Interactions
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textmining
co-expression
protein homology
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EIF2B1Translation initiation factor eIF-2B subunit alpha; Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP (305 aa)    
Predicted Functional Partners:
EIF2B5
Translation initiation factor eIF-2B subunit epsilon; Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP; Belongs to the eIF-2B gamma/epsilon subunits family (721 aa)
     
  0.999
EIF2B3
Translation initiation factor eIF-2B subunit gamma; Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP; Belongs to the eIF-2B gamma/epsilon subunits family (452 aa)
     
  0.999
EIF2B2
Translation initiation factor eIF-2B subunit beta; Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP; Belongs to the eIF-2B alpha/beta/delta subunits family (351 aa)
   
0.999
EIF2S1
Eukaryotic translation initiation factor 2 subunit 1; Functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S pre-initiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2- GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed b [...] (315 aa)
     
  0.994
EIF2B4
Translation initiation factor eIF-2B subunit delta; Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP (543 aa)
   
0.991
EIF2S2
Eukaryotic translation initiation factor 2 subunit 2; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyz [...] (333 aa)
     
  0.990
EIF2S3
Eukaryotic translation initiation factor 2 subunit 3; As a subunit of eukaryotic initiation factor 2 (eIF2), involved in the early steps of protein synthesis. In the presence of GTP, eIF2 forms a ternary complex with initiator tRNA Met-tRNAi and then recruits the 40S ribosomal complex, a step that determines the rate of protein translation. This step is followed by mRNA binding to form the 43S pre-initiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex. In o [...] (472 aa)
     
  0.979
RD3
Protein RD3; Retinal degeneration 3 (195 aa)
       
      0.798
EIF2AK4
eIF-2-alpha kinase GCN2; Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (eIF-2-alpha/EIF2S1) on ’Ser-52’ in response to low amino acid availability. Plays a role as an activator of the integrated stress response (ISR) required for adapatation to amino acid starvation. Converts phosphorylated eIF- 2-alpha/EIF2S1 either to a competitive inhibitor of the translation initiation factor eIF-2B, leading to a global protein synthesis repression, and thus to a reduced overall utilization of amino acids, or to a transla [...] (1649 aa)
     
 
  0.742
EIF2S3L
Putative eukaryotic translation initiation factor 2 subunit 3-like protein; As a subunit of eukaryotic initiation factor 2 (eIF2), involved in the early steps of protein synthesis. In the presence of GTP, eIF2 forms a ternary complex with initiator tRNA Met-tRNAi and then recruits the 40S ribosomal complex, a step that determines the rate of protein translation. This step is followed by mRNA binding to form the 43S pre-initiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GD [...] (472 aa)
     
 
  0.685
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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