| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| FLVCR1 | PPOX | ENSP00000355938 | ENSP00000356978 | Feline leukemia virus subgroup C receptor-related protein 1; Isoform 1- Heme transporter that exports cytoplasmic heme. It can also export coproporphyrin and protoporphyrin IX, which are both intermediate products in the heme biosynthetic pathway. Does not export bilirubin. Heme export depends on the presence of HPX and is required to maintain intracellular free heme balance, protecting cells from heme toxicity. Heme export provides protection from heme or ferrous iron toxicities in liver, brain, sensory neurons and during erythtopoiesis, a process in which heme synthesis intensifies. [...] | Protoporphyrinogen oxidase; Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX | 0.575 |
| FLVCR1 | SLC46A1 | ENSP00000355938 | ENSP00000480703 | Feline leukemia virus subgroup C receptor-related protein 1; Isoform 1- Heme transporter that exports cytoplasmic heme. It can also export coproporphyrin and protoporphyrin IX, which are both intermediate products in the heme biosynthetic pathway. Does not export bilirubin. Heme export depends on the presence of HPX and is required to maintain intracellular free heme balance, protecting cells from heme toxicity. Heme export provides protection from heme or ferrous iron toxicities in liver, brain, sensory neurons and during erythtopoiesis, a process in which heme synthesis intensifies. [...] | Proton-coupled folate transporter; Has been shown to act both as an intestinal proton- coupled high-affinity folate transporter and as an intestinal heme transporter which mediates heme uptake from the gut lumen into duodenal epithelial cells. The iron is then released from heme and may be transported into the bloodstream. Dietary heme iron is an important nutritional source of iron. Shows a higher affinity for folate than heme; Solute carriers | 0.772 |
| FLVCR1 | SLC48A1 | ENSP00000355938 | ENSP00000415998 | Feline leukemia virus subgroup C receptor-related protein 1; Isoform 1- Heme transporter that exports cytoplasmic heme. It can also export coproporphyrin and protoporphyrin IX, which are both intermediate products in the heme biosynthetic pathway. Does not export bilirubin. Heme export depends on the presence of HPX and is required to maintain intracellular free heme balance, protecting cells from heme toxicity. Heme export provides protection from heme or ferrous iron toxicities in liver, brain, sensory neurons and during erythtopoiesis, a process in which heme synthesis intensifies. [...] | Heme transporter HRG1; Heme transporter that regulates intracellular heme availability through the endosomal or lysosomal compartment; Solute carriers | 0.632 |
| FLVCR2 | PPOX | ENSP00000238667 | ENSP00000356978 | Feline leukemia virus subgroup C receptor-related protein 2; Acts as an importer of heme. Also acts as a transporter for a calcium-chelator complex, important for growth and calcium metabolism; Solute carriers | Protoporphyrinogen oxidase; Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX | 0.625 |
| FLVCR2 | SLC46A1 | ENSP00000238667 | ENSP00000480703 | Feline leukemia virus subgroup C receptor-related protein 2; Acts as an importer of heme. Also acts as a transporter for a calcium-chelator complex, important for growth and calcium metabolism; Solute carriers | Proton-coupled folate transporter; Has been shown to act both as an intestinal proton- coupled high-affinity folate transporter and as an intestinal heme transporter which mediates heme uptake from the gut lumen into duodenal epithelial cells. The iron is then released from heme and may be transported into the bloodstream. Dietary heme iron is an important nutritional source of iron. Shows a higher affinity for folate than heme; Solute carriers | 0.720 |
| FLVCR2 | SLC48A1 | ENSP00000238667 | ENSP00000415998 | Feline leukemia virus subgroup C receptor-related protein 2; Acts as an importer of heme. Also acts as a transporter for a calcium-chelator complex, important for growth and calcium metabolism; Solute carriers | Heme transporter HRG1; Heme transporter that regulates intracellular heme availability through the endosomal or lysosomal compartment; Solute carriers | 0.624 |
| LARP4 | SLC48A1 | ENSP00000381490 | ENSP00000415998 | La-related protein 4; RNA binding protein that binds to the poly-A tract of mRNA molecules. Associates with the 40S ribosomal subunit and with polysomes. Plays a role in the regulation of mRNA translation. Plays a role in the regulation of cell morphology and cytoskeletal organization; La ribonucleoprotein domain containing | Heme transporter HRG1; Heme transporter that regulates intracellular heme availability through the endosomal or lysosomal compartment; Solute carriers | 0.652 |
| PPOX | FLVCR1 | ENSP00000356978 | ENSP00000355938 | Protoporphyrinogen oxidase; Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX | Feline leukemia virus subgroup C receptor-related protein 1; Isoform 1- Heme transporter that exports cytoplasmic heme. It can also export coproporphyrin and protoporphyrin IX, which are both intermediate products in the heme biosynthetic pathway. Does not export bilirubin. Heme export depends on the presence of HPX and is required to maintain intracellular free heme balance, protecting cells from heme toxicity. Heme export provides protection from heme or ferrous iron toxicities in liver, brain, sensory neurons and during erythtopoiesis, a process in which heme synthesis intensifies. [...] | 0.575 |
| PPOX | FLVCR2 | ENSP00000356978 | ENSP00000238667 | Protoporphyrinogen oxidase; Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX | Feline leukemia virus subgroup C receptor-related protein 2; Acts as an importer of heme. Also acts as a transporter for a calcium-chelator complex, important for growth and calcium metabolism; Solute carriers | 0.625 |
| PPOX | SLC46A1 | ENSP00000356978 | ENSP00000480703 | Protoporphyrinogen oxidase; Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX | Proton-coupled folate transporter; Has been shown to act both as an intestinal proton- coupled high-affinity folate transporter and as an intestinal heme transporter which mediates heme uptake from the gut lumen into duodenal epithelial cells. The iron is then released from heme and may be transported into the bloodstream. Dietary heme iron is an important nutritional source of iron. Shows a higher affinity for folate than heme; Solute carriers | 0.437 |
| PPOX | SLC48A1 | ENSP00000356978 | ENSP00000415998 | Protoporphyrinogen oxidase; Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX | Heme transporter HRG1; Heme transporter that regulates intracellular heme availability through the endosomal or lysosomal compartment; Solute carriers | 0.618 |
| SLC25A46 | SLC26A11 | ENSP00000348211 | ENSP00000355384 | Solute carrier family 25 member 46; May play a role in mitochondrial dynamics by controlling mitochondrial membrane fission; Belongs to the mitochondrial carrier (TC 2.A.29) family | Sodium-independent sulfate anion transporter; Exhibits sodium-independent sulfate anion transporter activity that may cooperate with SLC26A2 to mediate DIDS-sensitive sulfate uptake into high endothelial venules endothelial cells (HEVEC); Solute carriers | 0.555 |
| SLC25A46 | SLC48A1 | ENSP00000348211 | ENSP00000415998 | Solute carrier family 25 member 46; May play a role in mitochondrial dynamics by controlling mitochondrial membrane fission; Belongs to the mitochondrial carrier (TC 2.A.29) family | Heme transporter HRG1; Heme transporter that regulates intracellular heme availability through the endosomal or lysosomal compartment; Solute carriers | 0.610 |
| SLC25A46 | SLC7A6OS | ENSP00000348211 | ENSP00000263997 | Solute carrier family 25 member 46; May play a role in mitochondrial dynamics by controlling mitochondrial membrane fission; Belongs to the mitochondrial carrier (TC 2.A.29) family | Probable RNA polymerase II nuclear localization protein SLC7A6OS; Directs RNA polymerase II nuclear import | 0.635 |
| SLC25A46 | SLC9A8 | ENSP00000348211 | ENSP00000416418 | Solute carrier family 25 member 46; May play a role in mitochondrial dynamics by controlling mitochondrial membrane fission; Belongs to the mitochondrial carrier (TC 2.A.29) family | Sodium/hydrogen exchanger 8; Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction; Belongs to the monovalent cation-proton antiporter 1 (CPA1) transporter (TC 2.A.36) family | 0.603 |
| SLC26A11 | SLC25A46 | ENSP00000355384 | ENSP00000348211 | Sodium-independent sulfate anion transporter; Exhibits sodium-independent sulfate anion transporter activity that may cooperate with SLC26A2 to mediate DIDS-sensitive sulfate uptake into high endothelial venules endothelial cells (HEVEC); Solute carriers | Solute carrier family 25 member 46; May play a role in mitochondrial dynamics by controlling mitochondrial membrane fission; Belongs to the mitochondrial carrier (TC 2.A.29) family | 0.555 |
| SLC26A11 | SLC48A1 | ENSP00000355384 | ENSP00000415998 | Sodium-independent sulfate anion transporter; Exhibits sodium-independent sulfate anion transporter activity that may cooperate with SLC26A2 to mediate DIDS-sensitive sulfate uptake into high endothelial venules endothelial cells (HEVEC); Solute carriers | Heme transporter HRG1; Heme transporter that regulates intracellular heme availability through the endosomal or lysosomal compartment; Solute carriers | 0.517 |
| SLC26A11 | SLC7A6OS | ENSP00000355384 | ENSP00000263997 | Sodium-independent sulfate anion transporter; Exhibits sodium-independent sulfate anion transporter activity that may cooperate with SLC26A2 to mediate DIDS-sensitive sulfate uptake into high endothelial venules endothelial cells (HEVEC); Solute carriers | Probable RNA polymerase II nuclear localization protein SLC7A6OS; Directs RNA polymerase II nuclear import | 0.542 |
| SLC26A11 | SLC9A8 | ENSP00000355384 | ENSP00000416418 | Sodium-independent sulfate anion transporter; Exhibits sodium-independent sulfate anion transporter activity that may cooperate with SLC26A2 to mediate DIDS-sensitive sulfate uptake into high endothelial venules endothelial cells (HEVEC); Solute carriers | Sodium/hydrogen exchanger 8; Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction; Belongs to the monovalent cation-proton antiporter 1 (CPA1) transporter (TC 2.A.36) family | 0.515 |
| SLC46A1 | FLVCR1 | ENSP00000480703 | ENSP00000355938 | Proton-coupled folate transporter; Has been shown to act both as an intestinal proton- coupled high-affinity folate transporter and as an intestinal heme transporter which mediates heme uptake from the gut lumen into duodenal epithelial cells. The iron is then released from heme and may be transported into the bloodstream. Dietary heme iron is an important nutritional source of iron. Shows a higher affinity for folate than heme; Solute carriers | Feline leukemia virus subgroup C receptor-related protein 1; Isoform 1- Heme transporter that exports cytoplasmic heme. It can also export coproporphyrin and protoporphyrin IX, which are both intermediate products in the heme biosynthetic pathway. Does not export bilirubin. Heme export depends on the presence of HPX and is required to maintain intracellular free heme balance, protecting cells from heme toxicity. Heme export provides protection from heme or ferrous iron toxicities in liver, brain, sensory neurons and during erythtopoiesis, a process in which heme synthesis intensifies. [...] | 0.772 |
