• Version:
  • 11.0 [archived version]
STRINGSTRING
MC1R MC1R GAS8 GAS8 LRWD1 LRWD1 ZNF276 ZNF276 NAIF1 NAIF1 FSBP FSBP CDK10 CDK10 SRBD1 SRBD1 ZNF827 ZNF827 GALNS GALNS FANCA FANCA
"ZNF276" - Zinc finger protein 276 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ZNF276Zinc finger protein 276; May be involved in transcriptional regulation; Zinc fingers C2H2-type (614 aa)    
Predicted Functional Partners:
ZNF827
Zinc finger protein 827; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family (1077 aa)
           
  0.780
FSBP
Fibrinogen silencer-binding protein; Transcriptional repressor that down-regulates the expression of the fibrinogen gamma chain. Represses transcription of GSK3B gene promoter via its interaction with APBA1 (299 aa)
           
  0.743
CDK10
Cyclin-dependent kinase 10; Cyclin-dependent kinase that phosphorylates the transcription factor ETS2 (in vitro) and positively controls its proteasomal degradation (in cells) (360 aa)
     
   
  0.738
SRBD1
S1 RNA-binding domain-containing protein 1; S1 RNA binding domain 1 (995 aa)
     
 
  0.735
GAS8
Growth arrest-specific protein 8; Cytoskeletal linker which binds microtubules and probably functions in axonemal and non-axonemal dynein regulation. May play a role in the spermatozoa motility (By similarity). May play a role in cilia motility; Dynein regulatory complex (478 aa)
     
   
  0.725
NAIF1
Nuclear apoptosis-inducing factor 1; Induces apoptosis; Belongs to the NAIF1 family (327 aa)
     
   
  0.703
MC1R
Melanocyte-stimulating hormone receptor; Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family (317 aa)
     
 
  0.654
FANCA
Fanconi anemia group A protein; DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be involved in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability; Fanconi anemia complementation groups (1455 aa)
           
  0.640
LRWD1
Leucine-rich repeat and WD repeat-containing protein 1; Required for G1/S transition. Recruits and stabilizes the origin recognition complex (ORC) onto chromatin during G1 to establish pre-replication complex (preRC) and to heterochromatic sites in post-replicated cells. Binds a combination of DNA and histone methylation repressive marks on heterochromatin. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3 in a cooperative manner with DNA methylation. Required for silencing of major satellite repeats. May be important ORC2, ORC3 and ORC4 stability; WD repeat d [...] (647 aa)
     
 
  0.636
GALNS
N-acetylgalactosamine-6-sulfatase; Galactosamine-6-sulfatase; Belongs to the sulfatase family (522 aa)
           
  0.627
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
Server load: low (1%) [HD]