| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| C10orf99 | IGFL1 | ENSP00000361199 | ENSP00000415823 | Protein GPR15L; Chemotactic factor that mediates lymphocytes recruitement to epithelia through binding and activation of the G- protein coupled receptor GPR15. May be a tumor suppressor; together with SUSD2 has a growth inhibitory effect on colon cancer cells which includes G1 cell cycle arrest | Insulin growth factor-like family member 1; Probable ligand of the IGFLR1 cell membrane receptor | 0.534 |
| CHAT | IGFL1 | ENSP00000337103 | ENSP00000415823 | Choline O-acetyltransferase; Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses; Belongs to the carnitine/choline acetyltransferase family | Insulin growth factor-like family member 1; Probable ligand of the IGFLR1 cell membrane receptor | 0.408 |
| IGFBPL1 | IGFL1 | ENSP00000366923 | ENSP00000415823 | Insulin-like growth factor-binding protein-like 1; IGF-binding proteins prolong the half-life of IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs in cell culture. They alter the interaction of IGFs with their cell surface receptors (By similarity). May be a putative tumor suppressor protein; I-set domain containing | Insulin growth factor-like family member 1; Probable ligand of the IGFLR1 cell membrane receptor | 0.417 |
| IGFBPL1 | NKAIN1 | ENSP00000366923 | ENSP00000362841 | Insulin-like growth factor-binding protein-like 1; IGF-binding proteins prolong the half-life of IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs in cell culture. They alter the interaction of IGFs with their cell surface receptors (By similarity). May be a putative tumor suppressor protein; I-set domain containing | Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 1; Sodium/potassium transporting ATPase interacting 1 | 0.472 |
| IGFBPL1 | SDR16C5 | ENSP00000366923 | ENSP00000307607 | Insulin-like growth factor-binding protein-like 1; IGF-binding proteins prolong the half-life of IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs in cell culture. They alter the interaction of IGFs with their cell surface receptors (By similarity). May be a putative tumor suppressor protein; I-set domain containing | Epidermal retinol dehydrogenase 2; Oxidoreductase with strong preference for NAD. Active in both the oxidative and reductive directions. Oxidizes all-trans- retinol in all-trans-retinaldehyde. No activity was detected with 11-cis-retinol or 11-cis-retinaldehyde as substrates with either NAD(+)/NADH or NADP(+)/NADPH; Belongs to the short-chain dehydrogenases/reductases (SDR) family | 0.417 |
| IGFL1 | C10orf99 | ENSP00000415823 | ENSP00000361199 | Insulin growth factor-like family member 1; Probable ligand of the IGFLR1 cell membrane receptor | Protein GPR15L; Chemotactic factor that mediates lymphocytes recruitement to epithelia through binding and activation of the G- protein coupled receptor GPR15. May be a tumor suppressor; together with SUSD2 has a growth inhibitory effect on colon cancer cells which includes G1 cell cycle arrest | 0.534 |
| IGFL1 | CHAT | ENSP00000415823 | ENSP00000337103 | Insulin growth factor-like family member 1; Probable ligand of the IGFLR1 cell membrane receptor | Choline O-acetyltransferase; Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses; Belongs to the carnitine/choline acetyltransferase family | 0.408 |
| IGFL1 | IGFBPL1 | ENSP00000415823 | ENSP00000366923 | Insulin growth factor-like family member 1; Probable ligand of the IGFLR1 cell membrane receptor | Insulin-like growth factor-binding protein-like 1; IGF-binding proteins prolong the half-life of IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs in cell culture. They alter the interaction of IGFs with their cell surface receptors (By similarity). May be a putative tumor suppressor protein; I-set domain containing | 0.417 |
| IGFL1 | IGFN1 | ENSP00000415823 | ENSP00000334714 | Insulin growth factor-like family member 1; Probable ligand of the IGFLR1 cell membrane receptor | Immunoglobulin-like and fibronectin type III domain containing 1 | 0.428 |
| IGFL1 | MOCS1 | ENSP00000415823 | ENSP00000362282 | Insulin growth factor-like family member 1; Probable ligand of the IGFLR1 cell membrane receptor | Molybdenum cofactor biosynthesis protein 1; Isoform MOCS1A and isoform MOCS1B probably form a complex that catalyzes the conversion of 5’-GTP to cyclic pyranopterin monophosphate (cPMP). MOCS1A catalyzes the cyclization of GTP to (8S)-3’,8-cyclo-7,8-dihydroguanosine 5’- triphosphate and MOCS1B catalyzes the subsequent conversion of (8S)-3’,8-cyclo-7,8-dihydroguanosine 5’-triphosphate to cPMP; In the N-terminal section; belongs to the radical SAM superfamily. MoaA family | 0.407 |
| IGFL1 | NKAIN1 | ENSP00000415823 | ENSP00000362841 | Insulin growth factor-like family member 1; Probable ligand of the IGFLR1 cell membrane receptor | Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 1; Sodium/potassium transporting ATPase interacting 1 | 0.466 |
| IGFL1 | SDR16C5 | ENSP00000415823 | ENSP00000307607 | Insulin growth factor-like family member 1; Probable ligand of the IGFLR1 cell membrane receptor | Epidermal retinol dehydrogenase 2; Oxidoreductase with strong preference for NAD. Active in both the oxidative and reductive directions. Oxidizes all-trans- retinol in all-trans-retinaldehyde. No activity was detected with 11-cis-retinol or 11-cis-retinaldehyde as substrates with either NAD(+)/NADH or NADP(+)/NADPH; Belongs to the short-chain dehydrogenases/reductases (SDR) family | 0.461 |
| IGFL1 | SH2B2 | ENSP00000415823 | ENSP00000440273 | Insulin growth factor-like family member 1; Probable ligand of the IGFLR1 cell membrane receptor | SH2B adapter protein 2; Adapter protein for several members of the tyrosine kinase receptor family. Involved in multiple signaling pathways. May be involved in coupling from immunoreceptor to Ras signaling. Acts as a negative regulator of cytokine signaling in collaboration with CBL. Binds to EPOR and suppresses EPO-induced STAT5 activation, possibly through a masking effect on STAT5 docking sites in EPOR. Suppresses PDGF-induced mitogenesis. May induce cytoskeletal reorganization via interaction with VAV3 | 0.403 |
| IGFN1 | IGFL1 | ENSP00000334714 | ENSP00000415823 | Immunoglobulin-like and fibronectin type III domain containing 1 | Insulin growth factor-like family member 1; Probable ligand of the IGFLR1 cell membrane receptor | 0.428 |
| IGFN1 | NKAIN1 | ENSP00000334714 | ENSP00000362841 | Immunoglobulin-like and fibronectin type III domain containing 1 | Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 1; Sodium/potassium transporting ATPase interacting 1 | 0.491 |
| IGFN1 | SDR16C5 | ENSP00000334714 | ENSP00000307607 | Immunoglobulin-like and fibronectin type III domain containing 1 | Epidermal retinol dehydrogenase 2; Oxidoreductase with strong preference for NAD. Active in both the oxidative and reductive directions. Oxidizes all-trans- retinol in all-trans-retinaldehyde. No activity was detected with 11-cis-retinol or 11-cis-retinaldehyde as substrates with either NAD(+)/NADH or NADP(+)/NADPH; Belongs to the short-chain dehydrogenases/reductases (SDR) family | 0.406 |
| IGFN1 | SH2B2 | ENSP00000334714 | ENSP00000440273 | Immunoglobulin-like and fibronectin type III domain containing 1 | SH2B adapter protein 2; Adapter protein for several members of the tyrosine kinase receptor family. Involved in multiple signaling pathways. May be involved in coupling from immunoreceptor to Ras signaling. Acts as a negative regulator of cytokine signaling in collaboration with CBL. Binds to EPOR and suppresses EPO-induced STAT5 activation, possibly through a masking effect on STAT5 docking sites in EPOR. Suppresses PDGF-induced mitogenesis. May induce cytoskeletal reorganization via interaction with VAV3 | 0.408 |
| MOCS1 | IGFL1 | ENSP00000362282 | ENSP00000415823 | Molybdenum cofactor biosynthesis protein 1; Isoform MOCS1A and isoform MOCS1B probably form a complex that catalyzes the conversion of 5’-GTP to cyclic pyranopterin monophosphate (cPMP). MOCS1A catalyzes the cyclization of GTP to (8S)-3’,8-cyclo-7,8-dihydroguanosine 5’- triphosphate and MOCS1B catalyzes the subsequent conversion of (8S)-3’,8-cyclo-7,8-dihydroguanosine 5’-triphosphate to cPMP; In the N-terminal section; belongs to the radical SAM superfamily. MoaA family | Insulin growth factor-like family member 1; Probable ligand of the IGFLR1 cell membrane receptor | 0.407 |
| NKAIN1 | IGFBPL1 | ENSP00000362841 | ENSP00000366923 | Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 1; Sodium/potassium transporting ATPase interacting 1 | Insulin-like growth factor-binding protein-like 1; IGF-binding proteins prolong the half-life of IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs in cell culture. They alter the interaction of IGFs with their cell surface receptors (By similarity). May be a putative tumor suppressor protein; I-set domain containing | 0.472 |
| NKAIN1 | IGFL1 | ENSP00000362841 | ENSP00000415823 | Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 1; Sodium/potassium transporting ATPase interacting 1 | Insulin growth factor-like family member 1; Probable ligand of the IGFLR1 cell membrane receptor | 0.466 |
