| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AMBN | AMELX | ENSP00000313809 | ENSP00000370088 | Ameloblastin; Involved in the mineralization and structural organization of enamel; Belongs to the ameloblastin family | Amelogenin, X isoform; Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel; Belongs to the amelogenin family | 0.995 |
| AMBN | AMTN | ENSP00000313809 | ENSP00000341013 | Ameloblastin; Involved in the mineralization and structural organization of enamel; Belongs to the ameloblastin family | Amelotin; Is a promoter of calcium phosphate mineralization, playing a critical role in the formation of the compact, mineralized, aprismatic enamel surface layer during the maturation stage of amelogenesis | 0.987 |
| AMBN | ENAM | ENSP00000313809 | ENSP00000379383 | Ameloblastin; Involved in the mineralization and structural organization of enamel; Belongs to the ameloblastin family | Enamelin; Involved in the mineralization and structural organization of enamel. Involved in the extension of enamel during the secretory stage of dental enamel formation | 0.992 |
| AMBN | FAM20C | ENSP00000313809 | ENSP00000322323 | Ameloblastin; Involved in the mineralization and structural organization of enamel; Belongs to the ameloblastin family | Extracellular serine/threonine protein kinase FAM20C; Golgi serine/threonine protein kinase that phosphorylates secretory pathway proteins within Ser-x-Glu/pSer motifs and plays a key role in biomineralization of bones and teeth. Constitutes the main protein kinase for extracellular proteins, generating the majority of the extracellular phosphoproteome. Mainly phosphorylates proteins within the Ser- x-Glu/pSer motif, but also displays a broader substrate specificity. Phosphorylates casein as well as a number of proteins involved in biomineralization such as AMELX, AMTN, ENAM and SPP1. [...] | 0.971 |
| AMBN | FN1 | ENSP00000313809 | ENSP00000346839 | Ameloblastin; Involved in the mineralization and structural organization of enamel; Belongs to the ameloblastin family | Fibronectin type III domain containing; Endogenous ligands | 0.923 |
| AMBN | FSTL1 | ENSP00000313809 | ENSP00000295633 | Ameloblastin; Involved in the mineralization and structural organization of enamel; Belongs to the ameloblastin family | Follistatin-related protein 1; May modulate the action of some growth factors on cell proliferation and differentiation. Binds heparin (By similarity); SPARC family | 0.900 |
| AMBN | GPC3 | ENSP00000313809 | ENSP00000377836 | Ameloblastin; Involved in the mineralization and structural organization of enamel; Belongs to the ameloblastin family | Glypican-3; Cell surface proteoglycan that bears heparan sulfate. Inhibits the dipeptidyl peptidase activity of DPP4. May be involved in the suppression/modulation of growth in the predominantly mesodermal tissues and organs. May play a role in the modulation of IGF2 interactions with its receptor and thereby modulate its function. May regulate growth and tumor predisposition; Glypicans | 0.902 |
| AMBN | MEPE | ENSP00000313809 | ENSP00000416984 | Ameloblastin; Involved in the mineralization and structural organization of enamel; Belongs to the ameloblastin family | Matrix extracellular phosphoglycoprotein; Promotes renal phosphate excretion and modulates mineralization; SIBLING family | 0.951 |
| AMBN | SPARCL1 | ENSP00000313809 | ENSP00000414856 | Ameloblastin; Involved in the mineralization and structural organization of enamel; Belongs to the ameloblastin family | SPARC-like protein 1; SPARC family | 0.972 |
| AMBN | SPP1 | ENSP00000313809 | ENSP00000378517 | Ameloblastin; Involved in the mineralization and structural organization of enamel; Belongs to the ameloblastin family | Osteopontin; Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction; Endogenous ligands | 0.943 |
| AMELX | AMBN | ENSP00000370088 | ENSP00000313809 | Amelogenin, X isoform; Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel; Belongs to the amelogenin family | Ameloblastin; Involved in the mineralization and structural organization of enamel; Belongs to the ameloblastin family | 0.995 |
| AMELX | AMTN | ENSP00000370088 | ENSP00000341013 | Amelogenin, X isoform; Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel; Belongs to the amelogenin family | Amelotin; Is a promoter of calcium phosphate mineralization, playing a critical role in the formation of the compact, mineralized, aprismatic enamel surface layer during the maturation stage of amelogenesis | 0.982 |
| AMELX | ENAM | ENSP00000370088 | ENSP00000379383 | Amelogenin, X isoform; Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel; Belongs to the amelogenin family | Enamelin; Involved in the mineralization and structural organization of enamel. Involved in the extension of enamel during the secretory stage of dental enamel formation | 0.995 |
| AMELX | FAM20C | ENSP00000370088 | ENSP00000322323 | Amelogenin, X isoform; Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel; Belongs to the amelogenin family | Extracellular serine/threonine protein kinase FAM20C; Golgi serine/threonine protein kinase that phosphorylates secretory pathway proteins within Ser-x-Glu/pSer motifs and plays a key role in biomineralization of bones and teeth. Constitutes the main protein kinase for extracellular proteins, generating the majority of the extracellular phosphoproteome. Mainly phosphorylates proteins within the Ser- x-Glu/pSer motif, but also displays a broader substrate specificity. Phosphorylates casein as well as a number of proteins involved in biomineralization such as AMELX, AMTN, ENAM and SPP1. [...] | 0.974 |
| AMELX | FN1 | ENSP00000370088 | ENSP00000346839 | Amelogenin, X isoform; Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel; Belongs to the amelogenin family | Fibronectin type III domain containing; Endogenous ligands | 0.927 |
| AMELX | FSTL1 | ENSP00000370088 | ENSP00000295633 | Amelogenin, X isoform; Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel; Belongs to the amelogenin family | Follistatin-related protein 1; May modulate the action of some growth factors on cell proliferation and differentiation. Binds heparin (By similarity); SPARC family | 0.900 |
| AMELX | GPC3 | ENSP00000370088 | ENSP00000377836 | Amelogenin, X isoform; Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel; Belongs to the amelogenin family | Glypican-3; Cell surface proteoglycan that bears heparan sulfate. Inhibits the dipeptidyl peptidase activity of DPP4. May be involved in the suppression/modulation of growth in the predominantly mesodermal tissues and organs. May play a role in the modulation of IGF2 interactions with its receptor and thereby modulate its function. May regulate growth and tumor predisposition; Glypicans | 0.900 |
| AMELX | MEPE | ENSP00000370088 | ENSP00000416984 | Amelogenin, X isoform; Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel; Belongs to the amelogenin family | Matrix extracellular phosphoglycoprotein; Promotes renal phosphate excretion and modulates mineralization; SIBLING family | 0.941 |
| AMELX | SPARCL1 | ENSP00000370088 | ENSP00000414856 | Amelogenin, X isoform; Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel; Belongs to the amelogenin family | SPARC-like protein 1; SPARC family | 0.940 |
| AMELX | SPP1 | ENSP00000370088 | ENSP00000378517 | Amelogenin, X isoform; Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel; Belongs to the amelogenin family | Osteopontin; Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction; Endogenous ligands | 0.945 |
