| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ALS2CR11 | FAM177B | ENSP00000409937 | ENSP00000414451 | C2 calcium-dependent domain-containing protein 6; Amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 11 | Protein FAM177B; Family with sequence similarity 177 member B | 0.582 |
| ALS2CR11 | PRKRIP1 | ENSP00000409937 | ENSP00000419270 | C2 calcium-dependent domain-containing protein 6; Amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 11 | PRKR-interacting protein 1; Binds double-stranded RNA. Inhibits EIF2AK2 kinase activity (By similarity); Zinc fingers C2H2-type | 0.471 |
| ENSG00000251184 | FAM177B | ENSP00000417556 | ENSP00000414451 | Uncharacterized protein | Protein FAM177B; Family with sequence similarity 177 member B | 0.416 |
| ENSG00000259075 | FAM177B | ENSP00000447852 | ENSP00000414451 | Polypeptide N-acetylgalactosaminyltransferase; POC1B-GALNT4 readthrough | Protein FAM177B; Family with sequence similarity 177 member B | 0.471 |
| ENSG00000259075 | MGAT1 | ENSP00000447852 | ENSP00000404718 | Polypeptide N-acetylgalactosaminyltransferase; POC1B-GALNT4 readthrough | Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase; Initiates complex N-linked carbohydrate formation. Essential for the conversion of high-mannose to hybrid and complex N-glycans; Mannosyl-glycoprotein N-acetylglucosaminyltransferases | 0.530 |
| FAM177B | ALS2CR11 | ENSP00000414451 | ENSP00000409937 | Protein FAM177B; Family with sequence similarity 177 member B | C2 calcium-dependent domain-containing protein 6; Amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 11 | 0.582 |
| FAM177B | ENSG00000251184 | ENSP00000414451 | ENSP00000417556 | Protein FAM177B; Family with sequence similarity 177 member B | Uncharacterized protein | 0.416 |
| FAM177B | ENSG00000259075 | ENSP00000414451 | ENSP00000447852 | Protein FAM177B; Family with sequence similarity 177 member B | Polypeptide N-acetylgalactosaminyltransferase; POC1B-GALNT4 readthrough | 0.471 |
| FAM177B | GALNT12 | ENSP00000414451 | ENSP00000364150 | Protein FAM177B; Family with sequence similarity 177 member B | Polypeptide N-acetylgalactosaminyltransferase 12; Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D- galactosamine residue to a serine or threonine residue on the protein receptor. Has activity toward non-glycosylated peptides such as Muc5AC, Muc1a and EA2, and no detectable activity with Muc2 and Muc7. Displays enzymatic activity toward the Gal-NAc- Muc5AC glycopeptide, but no detectable activity to mono-GalNAc- glycosylated Muc1a, Muc2, Muc7 and EA2. May play an important role in the initial step of mucin-type oligosaccharide biosy [...] | 0.426 |
| FAM177B | GALNT15 | ENSP00000414451 | ENSP00000344260 | Protein FAM177B; Family with sequence similarity 177 member B | Polypeptide N-acetylgalactosaminyltransferase 15; Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D- galactosamine residue to a serine or threonine residue on the protein receptor. Although it displays a much weaker activity toward all substrates tested compared to GALNT2, it is able to transfer up to seven GalNAc residues to the Muc5AC peptide, suggesting that it can fill vicinal Thr/Ser residues in cooperation with other GALNT proteins. Prefers Muc1a as substrate; Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily | 0.626 |
| FAM177B | GALNT4 | ENSP00000414451 | ENSP00000436604 | Protein FAM177B; Family with sequence similarity 177 member B | Polypeptide N-acetylgalactosaminyltransferase 4; Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D- galactosamine residue to a serine or threonine residue on the protein receptor. Has a highest activity toward Muc7, EA2 and Muc2, with a lowest activity than GALNT2. Glycosylates ’Thr-57’ of SELPLG; Polypeptide N-acetylgalactosaminyltransferases | 0.471 |
| FAM177B | GALNT9 | ENSP00000414451 | ENSP00000380488 | Protein FAM177B; Family with sequence similarity 177 member B | Polypeptide N-acetylgalactosaminyltransferase 9; Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D- galactosamine residue to a serine or threonine residue on the protein receptor. Does not glycosylate apomucin or SDC3; Polypeptide N-acetylgalactosaminyltransferases | 0.414 |
| FAM177B | MGAT1 | ENSP00000414451 | ENSP00000404718 | Protein FAM177B; Family with sequence similarity 177 member B | Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase; Initiates complex N-linked carbohydrate formation. Essential for the conversion of high-mannose to hybrid and complex N-glycans; Mannosyl-glycoprotein N-acetylglucosaminyltransferases | 0.441 |
| FAM177B | NUP188 | ENSP00000414451 | ENSP00000361658 | Protein FAM177B; Family with sequence similarity 177 member B | Nucleoporin NUP188 homolog; May function as a component of the nuclear pore complex (NPC); Armadillo-like helical domain containing | 0.416 |
| FAM177B | PRKRIP1 | ENSP00000414451 | ENSP00000419270 | Protein FAM177B; Family with sequence similarity 177 member B | PRKR-interacting protein 1; Binds double-stranded RNA. Inhibits EIF2AK2 kinase activity (By similarity); Zinc fingers C2H2-type | 0.531 |
| GALNT12 | FAM177B | ENSP00000364150 | ENSP00000414451 | Polypeptide N-acetylgalactosaminyltransferase 12; Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D- galactosamine residue to a serine or threonine residue on the protein receptor. Has activity toward non-glycosylated peptides such as Muc5AC, Muc1a and EA2, and no detectable activity with Muc2 and Muc7. Displays enzymatic activity toward the Gal-NAc- Muc5AC glycopeptide, but no detectable activity to mono-GalNAc- glycosylated Muc1a, Muc2, Muc7 and EA2. May play an important role in the initial step of mucin-type oligosaccharide biosy [...] | Protein FAM177B; Family with sequence similarity 177 member B | 0.426 |
| GALNT12 | MGAT1 | ENSP00000364150 | ENSP00000404718 | Polypeptide N-acetylgalactosaminyltransferase 12; Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D- galactosamine residue to a serine or threonine residue on the protein receptor. Has activity toward non-glycosylated peptides such as Muc5AC, Muc1a and EA2, and no detectable activity with Muc2 and Muc7. Displays enzymatic activity toward the Gal-NAc- Muc5AC glycopeptide, but no detectable activity to mono-GalNAc- glycosylated Muc1a, Muc2, Muc7 and EA2. May play an important role in the initial step of mucin-type oligosaccharide biosy [...] | Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase; Initiates complex N-linked carbohydrate formation. Essential for the conversion of high-mannose to hybrid and complex N-glycans; Mannosyl-glycoprotein N-acetylglucosaminyltransferases | 0.575 |
| GALNT15 | FAM177B | ENSP00000344260 | ENSP00000414451 | Polypeptide N-acetylgalactosaminyltransferase 15; Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D- galactosamine residue to a serine or threonine residue on the protein receptor. Although it displays a much weaker activity toward all substrates tested compared to GALNT2, it is able to transfer up to seven GalNAc residues to the Muc5AC peptide, suggesting that it can fill vicinal Thr/Ser residues in cooperation with other GALNT proteins. Prefers Muc1a as substrate; Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily | Protein FAM177B; Family with sequence similarity 177 member B | 0.626 |
| GALNT15 | MGAT1 | ENSP00000344260 | ENSP00000404718 | Polypeptide N-acetylgalactosaminyltransferase 15; Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D- galactosamine residue to a serine or threonine residue on the protein receptor. Although it displays a much weaker activity toward all substrates tested compared to GALNT2, it is able to transfer up to seven GalNAc residues to the Muc5AC peptide, suggesting that it can fill vicinal Thr/Ser residues in cooperation with other GALNT proteins. Prefers Muc1a as substrate; Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily | Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase; Initiates complex N-linked carbohydrate formation. Essential for the conversion of high-mannose to hybrid and complex N-glycans; Mannosyl-glycoprotein N-acetylglucosaminyltransferases | 0.648 |
| GALNT4 | FAM177B | ENSP00000436604 | ENSP00000414451 | Polypeptide N-acetylgalactosaminyltransferase 4; Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D- galactosamine residue to a serine or threonine residue on the protein receptor. Has a highest activity toward Muc7, EA2 and Muc2, with a lowest activity than GALNT2. Glycosylates ’Thr-57’ of SELPLG; Polypeptide N-acetylgalactosaminyltransferases | Protein FAM177B; Family with sequence similarity 177 member B | 0.471 |
