node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EPS15 | SPG20 | ENSP00000360798 | ENSP00000414147 | Epidermal growth factor receptor substrate 15; Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Acts as a clathrin adapter required for post-Golgi trafficking. Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta- 1 (ITGB1) and transferrin receptor (TFR); internali [...] | Spartin; May be implicated in endosomal trafficking, or microtubule dynamics, or both. Participates in cytokinesis | 0.947 |
FCHSD2 | HLA-C | ENSP00000386722 | ENSP00000365402 | FCH and double SH3 domains 2; F-BAR domain containing | HLA class I histocompatibility antigen, Cw-7 alpha chain; Involved in the presentation of foreign antigens to the immune system; Belongs to the MHC class I family | 0.556 |
FCHSD2 | SORBS1 | ENSP00000386722 | ENSP00000360293 | FCH and double SH3 domains 2; F-BAR domain containing | Sorbin and SH3 domain-containing protein 1; Plays a role in tyrosine phosphorylation of CBL by linking CBL to the insulin receptor. Required for insulin- stimulated glucose transport. Involved in formation of actin stress fibers and focal adhesions (By similarity) | 0.796 |
FCHSD2 | SPG20 | ENSP00000386722 | ENSP00000414147 | FCH and double SH3 domains 2; F-BAR domain containing | Spartin; May be implicated in endosomal trafficking, or microtubule dynamics, or both. Participates in cytokinesis | 0.802 |
FCHSD2 | STAC | ENSP00000386722 | ENSP00000273183 | FCH and double SH3 domains 2; F-BAR domain containing | SH3 and cysteine-rich domain-containing protein; Probably involved in a neuron-specific signal transduction | 0.840 |
FCHSD2 | TRIM45 | ENSP00000386722 | ENSP00000256649 | FCH and double SH3 domains 2; F-BAR domain containing | Tripartite motif-containing protein 45; May act as a transcriptional repressor in mitogen- activated protein kinase signaling pathway; Ring finger proteins | 0.891 |
HLA-C | FCHSD2 | ENSP00000365402 | ENSP00000386722 | HLA class I histocompatibility antigen, Cw-7 alpha chain; Involved in the presentation of foreign antigens to the immune system; Belongs to the MHC class I family | FCH and double SH3 domains 2; F-BAR domain containing | 0.556 |
HLA-C | SORBS1 | ENSP00000365402 | ENSP00000360293 | HLA class I histocompatibility antigen, Cw-7 alpha chain; Involved in the presentation of foreign antigens to the immune system; Belongs to the MHC class I family | Sorbin and SH3 domain-containing protein 1; Plays a role in tyrosine phosphorylation of CBL by linking CBL to the insulin receptor. Required for insulin- stimulated glucose transport. Involved in formation of actin stress fibers and focal adhesions (By similarity) | 0.794 |
HLA-C | SPG20 | ENSP00000365402 | ENSP00000414147 | HLA class I histocompatibility antigen, Cw-7 alpha chain; Involved in the presentation of foreign antigens to the immune system; Belongs to the MHC class I family | Spartin; May be implicated in endosomal trafficking, or microtubule dynamics, or both. Participates in cytokinesis | 0.793 |
HLA-C | STAC | ENSP00000365402 | ENSP00000273183 | HLA class I histocompatibility antigen, Cw-7 alpha chain; Involved in the presentation of foreign antigens to the immune system; Belongs to the MHC class I family | SH3 and cysteine-rich domain-containing protein; Probably involved in a neuron-specific signal transduction | 0.533 |
HLA-C | TRIM45 | ENSP00000365402 | ENSP00000256649 | HLA class I histocompatibility antigen, Cw-7 alpha chain; Involved in the presentation of foreign antigens to the immune system; Belongs to the MHC class I family | Tripartite motif-containing protein 45; May act as a transcriptional repressor in mitogen- activated protein kinase signaling pathway; Ring finger proteins | 0.965 |
IST1 | SPG20 | ENSP00000438399 | ENSP00000414147 | IST1 homolog; ESCRT-III-like protein involved in specific functions of the ESCRT machinery. Is required for efficient abscission during cytokinesis, but not for HIV-1 budding. The involvement in the MVB pathway is not established. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells. During late anaphase, involved in nuclear envelope reassembly and mitotic spindle disassembly together with the ESCRT-III complex- IST1 acts by mediating the recruitment of SPAST to the nuclear membrane, leading to microtubule severing. Regulates early endosomal tubulation together wi [...] | Spartin; May be implicated in endosomal trafficking, or microtubule dynamics, or both. Participates in cytokinesis | 0.925 |
NIPA1 | PNPLA6 | ENSP00000337452 | ENSP00000407509 | Magnesium transporter NIPA1; Acts as a Mg(2+) transporter. Can also transport other divalent cations such as Fe(2+), Sr(2+), Ba(2+), Mn(2+) and Co(2+) but to a much less extent than Mg(2+) (By similarity); Belongs to the NIPA family | Neuropathy target esterase; Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Its specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy; Patatin like phospholipase domain containing | 0.522 |
NIPA1 | SPG20 | ENSP00000337452 | ENSP00000414147 | Magnesium transporter NIPA1; Acts as a Mg(2+) transporter. Can also transport other divalent cations such as Fe(2+), Sr(2+), Ba(2+), Mn(2+) and Co(2+) but to a much less extent than Mg(2+) (By similarity); Belongs to the NIPA family | Spartin; May be implicated in endosomal trafficking, or microtubule dynamics, or both. Participates in cytokinesis | 0.870 |
PLIN3 | SPG20 | ENSP00000221957 | ENSP00000414147 | Perilipin-3; Required for the transport of mannose 6-phosphate receptors (MPR) from endosomes to the trans-Golgi network; Perilipins | Spartin; May be implicated in endosomal trafficking, or microtubule dynamics, or both. Participates in cytokinesis | 0.751 |
PNPLA6 | NIPA1 | ENSP00000407509 | ENSP00000337452 | Neuropathy target esterase; Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Its specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy; Patatin like phospholipase domain containing | Magnesium transporter NIPA1; Acts as a Mg(2+) transporter. Can also transport other divalent cations such as Fe(2+), Sr(2+), Ba(2+), Mn(2+) and Co(2+) but to a much less extent than Mg(2+) (By similarity); Belongs to the NIPA family | 0.522 |
PNPLA6 | SPG20 | ENSP00000407509 | ENSP00000414147 | Neuropathy target esterase; Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Its specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy; Patatin like phospholipase domain containing | Spartin; May be implicated in endosomal trafficking, or microtubule dynamics, or both. Participates in cytokinesis | 0.760 |
SORBS1 | FCHSD2 | ENSP00000360293 | ENSP00000386722 | Sorbin and SH3 domain-containing protein 1; Plays a role in tyrosine phosphorylation of CBL by linking CBL to the insulin receptor. Required for insulin- stimulated glucose transport. Involved in formation of actin stress fibers and focal adhesions (By similarity) | FCH and double SH3 domains 2; F-BAR domain containing | 0.796 |
SORBS1 | HLA-C | ENSP00000360293 | ENSP00000365402 | Sorbin and SH3 domain-containing protein 1; Plays a role in tyrosine phosphorylation of CBL by linking CBL to the insulin receptor. Required for insulin- stimulated glucose transport. Involved in formation of actin stress fibers and focal adhesions (By similarity) | HLA class I histocompatibility antigen, Cw-7 alpha chain; Involved in the presentation of foreign antigens to the immune system; Belongs to the MHC class I family | 0.794 |
SORBS1 | SPG20 | ENSP00000360293 | ENSP00000414147 | Sorbin and SH3 domain-containing protein 1; Plays a role in tyrosine phosphorylation of CBL by linking CBL to the insulin receptor. Required for insulin- stimulated glucose transport. Involved in formation of actin stress fibers and focal adhesions (By similarity) | Spartin; May be implicated in endosomal trafficking, or microtubule dynamics, or both. Participates in cytokinesis | 0.838 |