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  • 11.0 [archived version]
STRINGSTRING
FADS6 FADS6 TMEM128 TMEM128 OTOP2 OTOP2 STAP2 STAP2 CDR2L CDR2L PTCRA PTCRA HID1 HID1 USP7 USP7 DENND2C DENND2C GPD1L GPD1L DYM DYM
"HID1" - Protein HID1 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
HID1Protein HID1; May play an important role in the development of cancers in a broad range of tissues (788 aa)    
Predicted Functional Partners:
USP7
Ubiquitin carboxyl-terminal hydrolase 7; Hydrolase that deubiquitinates target proteins such as FOXO4, p53/TP53, MDM2, ERCC6, DNMT1, UHRF1, PTEN and DAXX. Together with DAXX, prevents MDM2 self-ubiquitination and enhances the E3 ligase activity of MDM2 towards p53/TP53, thereby promoting p53/TP53 ubiquitination and proteasomal degradation. Deubiquitinates p53/TP53, preventing degradation of p53/TP53, and enhances p53/TP53- dependent transcription regulation, cell growth repression and apoptosis. Deubiquitinates p53/TP53 and MDM2 and strongly stabilizes p53/TP53 even in the presence of [...] (1102 aa)
     
 
  0.881
OTOP2
Otopetrin-2; Otopetrin 2 (562 aa)
           
  0.819
TMEM128
Transmembrane protein 128 (165 aa)
           
  0.774
PTCRA
Pre T-cell antigen receptor alpha; The pre-T-cell receptor complex (composed of PTCRA, TCRB and the CD3 complex) regulates early T-cell development (296 aa)
           
  0.716
CDR2L
Cerebellar degeneration related protein 2 like (465 aa)
     
   
  0.709
DENND2C
DENN domain-containing protein 2C; Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP- bound form; DENN/MADD domain containing (928 aa)
       
      0.692
STAP2
Signal transducing adaptor family member 2 (449 aa)
           
  0.643
GPD1L
Glycerol-3-phosphate dehydrogenase 1-like protein; Plays a role in regulating cardiac sodium current; decreased enzymatic activity with resulting increased levels of glycerol 3-phosphate activating the DPD1L-dependent SCN5A phosphorylation pathway, may ultimately lead to decreased sodium current; cardiac sodium current may also be reduced due to alterations of NAD(H) balance induced by DPD1L (351 aa)
     
        0.634
FADS6
Fatty acid desaturase 6; Belongs to the fatty acid desaturase type 1 family (368 aa)
           
  0.626
DYM
Dymeclin; Necessary for correct organization of Golgi apparatus. Involved in bone development; Belongs to the dymeclin family (669 aa)
     
   
  0.612
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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