| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CARD11 | F11R | ENSP00000380150 | ENSP00000357005 | Caspase recruitment domain-containing protein 11; Involved in the costimulatory signal essential for T- cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Activates NF-kappa-B via BCL10 and IKK. Stimulates the phosphorylation of BCL10. Also activates the TORC1 signaling pathway; CBM complex | Junctional adhesion molecule A; Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3. The association of the PARD6- PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly (By similarity). Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier (By similarity). Ligand for integrin alpha- L/beta-2 involved in memory T-cell and neutrophil transmigration. Involved in platelet activation; Belongs to the immunoglobulin superfamily | 0.429 |
| CARD11 | POU2F2 | ENSP00000380150 | ENSP00000431603 | Caspase recruitment domain-containing protein 11; Involved in the costimulatory signal essential for T- cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Activates NF-kappa-B via BCL10 and IKK. Stimulates the phosphorylation of BCL10. Also activates the TORC1 signaling pathway; CBM complex | POU domain, class 2, transcription factor 2; Transcription factor that specifically binds to the octamer motif (5’-ATTTGCAT-3’). Regulates transcription in a number of tissues in addition to activating immunoglobulin gene expression. Modulates transcription transactivation by NR3C1, AR and PGR. Isoform 5 activates the U2 small nuclear RNA (snRNA) promoter; POU class homeoboxes and pseudogenes | 0.461 |
| CARD11 | ZFHX2 | ENSP00000380150 | ENSP00000413418 | Caspase recruitment domain-containing protein 11; Involved in the costimulatory signal essential for T- cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Activates NF-kappa-B via BCL10 and IKK. Stimulates the phosphorylation of BCL10. Also activates the TORC1 signaling pathway; CBM complex | Zinc finger homeobox protein 2; May be involved in transcriptional regulation; ZF class homeoboxes and pseudogenes | 0.499 |
| DTNBP1 | ZFHX2 | ENSP00000341680 | ENSP00000413418 | Dysbindin; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Associates with the BLOC-2 complex to facilitate the transport of TYRP1 independent of AP-3 function. Plays a role i [...] | Zinc finger homeobox protein 2; May be involved in transcriptional regulation; ZF class homeoboxes and pseudogenes | 0.491 |
| F11R | CARD11 | ENSP00000357005 | ENSP00000380150 | Junctional adhesion molecule A; Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3. The association of the PARD6- PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly (By similarity). Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier (By similarity). Ligand for integrin alpha- L/beta-2 involved in memory T-cell and neutrophil transmigration. Involved in platelet activation; Belongs to the immunoglobulin superfamily | Caspase recruitment domain-containing protein 11; Involved in the costimulatory signal essential for T- cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Activates NF-kappa-B via BCL10 and IKK. Stimulates the phosphorylation of BCL10. Also activates the TORC1 signaling pathway; CBM complex | 0.429 |
| F11R | ZFHX2 | ENSP00000357005 | ENSP00000413418 | Junctional adhesion molecule A; Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3. The association of the PARD6- PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly (By similarity). Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier (By similarity). Ligand for integrin alpha- L/beta-2 involved in memory T-cell and neutrophil transmigration. Involved in platelet activation; Belongs to the immunoglobulin superfamily | Zinc finger homeobox protein 2; May be involved in transcriptional regulation; ZF class homeoboxes and pseudogenes | 0.489 |
| FAM89A | ZFHX2 | ENSP00000355614 | ENSP00000413418 | Protein FAM89A; Family with sequence similarity 89 member A; Belongs to the FAM89 family | Zinc finger homeobox protein 2; May be involved in transcriptional regulation; ZF class homeoboxes and pseudogenes | 0.474 |
| POU2F2 | CARD11 | ENSP00000431603 | ENSP00000380150 | POU domain, class 2, transcription factor 2; Transcription factor that specifically binds to the octamer motif (5’-ATTTGCAT-3’). Regulates transcription in a number of tissues in addition to activating immunoglobulin gene expression. Modulates transcription transactivation by NR3C1, AR and PGR. Isoform 5 activates the U2 small nuclear RNA (snRNA) promoter; POU class homeoboxes and pseudogenes | Caspase recruitment domain-containing protein 11; Involved in the costimulatory signal essential for T- cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Activates NF-kappa-B via BCL10 and IKK. Stimulates the phosphorylation of BCL10. Also activates the TORC1 signaling pathway; CBM complex | 0.461 |
| POU2F2 | ZFHX2 | ENSP00000431603 | ENSP00000413418 | POU domain, class 2, transcription factor 2; Transcription factor that specifically binds to the octamer motif (5’-ATTTGCAT-3’). Regulates transcription in a number of tissues in addition to activating immunoglobulin gene expression. Modulates transcription transactivation by NR3C1, AR and PGR. Isoform 5 activates the U2 small nuclear RNA (snRNA) promoter; POU class homeoboxes and pseudogenes | Zinc finger homeobox protein 2; May be involved in transcriptional regulation; ZF class homeoboxes and pseudogenes | 0.486 |
| SCN7A | ZFHX2 | ENSP00000386796 | ENSP00000413418 | Sodium channel protein type 7 subunit alpha; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient | Zinc finger homeobox protein 2; May be involved in transcriptional regulation; ZF class homeoboxes and pseudogenes | 0.567 |
| ZBED5 | ZFHX2 | ENSP00000398106 | ENSP00000413418 | Zinc finger BED-type containing 5 | Zinc finger homeobox protein 2; May be involved in transcriptional regulation; ZF class homeoboxes and pseudogenes | 0.475 |
| ZBED5 | ZNF701 | ENSP00000398106 | ENSP00000444339 | Zinc finger BED-type containing 5 | Zinc finger protein 701; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.589 |
| ZFHX2 | CARD11 | ENSP00000413418 | ENSP00000380150 | Zinc finger homeobox protein 2; May be involved in transcriptional regulation; ZF class homeoboxes and pseudogenes | Caspase recruitment domain-containing protein 11; Involved in the costimulatory signal essential for T- cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Activates NF-kappa-B via BCL10 and IKK. Stimulates the phosphorylation of BCL10. Also activates the TORC1 signaling pathway; CBM complex | 0.499 |
| ZFHX2 | DTNBP1 | ENSP00000413418 | ENSP00000341680 | Zinc finger homeobox protein 2; May be involved in transcriptional regulation; ZF class homeoboxes and pseudogenes | Dysbindin; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Associates with the BLOC-2 complex to facilitate the transport of TYRP1 independent of AP-3 function. Plays a role i [...] | 0.491 |
| ZFHX2 | F11R | ENSP00000413418 | ENSP00000357005 | Zinc finger homeobox protein 2; May be involved in transcriptional regulation; ZF class homeoboxes and pseudogenes | Junctional adhesion molecule A; Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3. The association of the PARD6- PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly (By similarity). Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier (By similarity). Ligand for integrin alpha- L/beta-2 involved in memory T-cell and neutrophil transmigration. Involved in platelet activation; Belongs to the immunoglobulin superfamily | 0.489 |
| ZFHX2 | FAM89A | ENSP00000413418 | ENSP00000355614 | Zinc finger homeobox protein 2; May be involved in transcriptional regulation; ZF class homeoboxes and pseudogenes | Protein FAM89A; Family with sequence similarity 89 member A; Belongs to the FAM89 family | 0.474 |
| ZFHX2 | POU2F2 | ENSP00000413418 | ENSP00000431603 | Zinc finger homeobox protein 2; May be involved in transcriptional regulation; ZF class homeoboxes and pseudogenes | POU domain, class 2, transcription factor 2; Transcription factor that specifically binds to the octamer motif (5’-ATTTGCAT-3’). Regulates transcription in a number of tissues in addition to activating immunoglobulin gene expression. Modulates transcription transactivation by NR3C1, AR and PGR. Isoform 5 activates the U2 small nuclear RNA (snRNA) promoter; POU class homeoboxes and pseudogenes | 0.486 |
| ZFHX2 | SCN7A | ENSP00000413418 | ENSP00000386796 | Zinc finger homeobox protein 2; May be involved in transcriptional regulation; ZF class homeoboxes and pseudogenes | Sodium channel protein type 7 subunit alpha; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient | 0.567 |
| ZFHX2 | ZBED5 | ENSP00000413418 | ENSP00000398106 | Zinc finger homeobox protein 2; May be involved in transcriptional regulation; ZF class homeoboxes and pseudogenes | Zinc finger BED-type containing 5 | 0.475 |
| ZFHX2 | ZFYVE27 | ENSP00000413418 | ENSP00000377282 | Zinc finger homeobox protein 2; May be involved in transcriptional regulation; ZF class homeoboxes and pseudogenes | Protrudin; Key regulator of RAB11-dependent vesicular trafficking during neurite extension through polarized membrane transport. Promotes axonal elongation and contributes to the establishment of neuronal cell polarity (By similarity). Involved in nerve growth factor-induced neurite formation in VAPA- dependent manner. Contributes to both the formation and stabilization of the tubular ER network. Involved in ER morphogenesis by regulating the sheet-to-tubule balance and possibly the density of tubule interconnections. Acts as an adapter protein and facilitates the interaction of KIF5A [...] | 0.580 |
