node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AKTIP | FAM160A1 | ENSP00000378152 | ENSP00000413196 | AKT-interacting protein; Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Regulates apoptosis by enhancing phosphorylation and activation of AKT1. Increases release of TNFSF6 via the AKT1/GSK3B/NFATC1 signaling cascade; Ubiquitin conjugating enzymes E2 | Protein FAM160A1; Family with sequence similarity 160 member A1; Belongs to the UPF0518 family | 0.916 |
AKTIP | HOOK1 | ENSP00000378152 | ENSP00000360252 | AKT-interacting protein; Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Regulates apoptosis by enhancing phosphorylation and activation of AKT1. Increases release of TNFSF6 via the AKT1/GSK3B/NFATC1 signaling cascade; Ubiquitin conjugating enzymes E2 | Protein Hook homolog 1; Required for spermatid differentiation. Probably involved in the positioning of the microtubules of the manchette and the flagellum in relation to the membrane skeleton (By similarity). Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex) | 0.987 |
AKTIP | HOOK3 | ENSP00000378152 | ENSP00000305699 | AKT-interacting protein; Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Regulates apoptosis by enhancing phosphorylation and activation of AKT1. Increases release of TNFSF6 via the AKT1/GSK3B/NFATC1 signaling cascade; Ubiquitin conjugating enzymes E2 | Protein Hook homolog 3; Probably serves as a target for the spiC protein from Salmonella typhimurium, which inactivates it, leading to a strong alteration in cellular trafficking (By similarity). Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). May regulate clearance of endocytosed receptors such as MSR1. Participates in defining the architecture and localization of the Golgi complex. Acts as an adapter protein linking the dynein motor c [...] | 0.996 |
CCDC64B | FAM160A1 | ENSP00000459043 | ENSP00000413196 | BICD family-like cargo adapter 2; Coiled-coil domain containing 64B | Protein FAM160A1; Family with sequence similarity 160 member A1; Belongs to the UPF0518 family | 0.576 |
CCDC64B | HOOK1 | ENSP00000459043 | ENSP00000360252 | BICD family-like cargo adapter 2; Coiled-coil domain containing 64B | Protein Hook homolog 1; Required for spermatid differentiation. Probably involved in the positioning of the microtubules of the manchette and the flagellum in relation to the membrane skeleton (By similarity). Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex) | 0.551 |
CCDC64B | HOOK3 | ENSP00000459043 | ENSP00000305699 | BICD family-like cargo adapter 2; Coiled-coil domain containing 64B | Protein Hook homolog 3; Probably serves as a target for the spiC protein from Salmonella typhimurium, which inactivates it, leading to a strong alteration in cellular trafficking (By similarity). Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). May regulate clearance of endocytosed receptors such as MSR1. Participates in defining the architecture and localization of the Golgi complex. Acts as an adapter protein linking the dynein motor c [...] | 0.479 |
FAM160A1 | AKTIP | ENSP00000413196 | ENSP00000378152 | Protein FAM160A1; Family with sequence similarity 160 member A1; Belongs to the UPF0518 family | AKT-interacting protein; Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Regulates apoptosis by enhancing phosphorylation and activation of AKT1. Increases release of TNFSF6 via the AKT1/GSK3B/NFATC1 signaling cascade; Ubiquitin conjugating enzymes E2 | 0.916 |
FAM160A1 | CCDC64B | ENSP00000413196 | ENSP00000459043 | Protein FAM160A1; Family with sequence similarity 160 member A1; Belongs to the UPF0518 family | BICD family-like cargo adapter 2; Coiled-coil domain containing 64B | 0.576 |
FAM160A1 | HOOK1 | ENSP00000413196 | ENSP00000360252 | Protein FAM160A1; Family with sequence similarity 160 member A1; Belongs to the UPF0518 family | Protein Hook homolog 1; Required for spermatid differentiation. Probably involved in the positioning of the microtubules of the manchette and the flagellum in relation to the membrane skeleton (By similarity). Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex) | 0.543 |
FAM160A1 | HOOK3 | ENSP00000413196 | ENSP00000305699 | Protein FAM160A1; Family with sequence similarity 160 member A1; Belongs to the UPF0518 family | Protein Hook homolog 3; Probably serves as a target for the spiC protein from Salmonella typhimurium, which inactivates it, leading to a strong alteration in cellular trafficking (By similarity). Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). May regulate clearance of endocytosed receptors such as MSR1. Participates in defining the architecture and localization of the Golgi complex. Acts as an adapter protein linking the dynein motor c [...] | 0.909 |
FAM160A1 | LZTS2 | ENSP00000413196 | ENSP00000359240 | Protein FAM160A1; Family with sequence similarity 160 member A1; Belongs to the UPF0518 family | Leucine zipper putative tumor suppressor 2; Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin; Belongs to the LZTS2 family | 0.546 |
FAM160A1 | NINL | ENSP00000413196 | ENSP00000278886 | Protein FAM160A1; Family with sequence similarity 160 member A1; Belongs to the UPF0518 family | Ninein-like protein; Involved in the microtubule organization in interphase cells. Overexpression induces the fragmentation of the Golgi, and causes lysosomes to disperse toward the cell periphery; it also interferes with mitotic spindle assembly. May play a role in ovarian carcinogenesis; EF-hand domain containing | 0.627 |
FAM160A1 | RIMBP3 | ENSP00000413196 | ENSP00000483386 | Protein FAM160A1; Family with sequence similarity 160 member A1; Belongs to the UPF0518 family | RIMS-binding protein 3A; Component of the manchette, a microtubule-based structure which plays a key role in sperm head morphogenesis during late stages of sperm development. Important for male fertility; Belongs to the RIMBP family | 0.554 |
FAM160A1 | SH3BP4 | ENSP00000413196 | ENSP00000386862 | Protein FAM160A1; Family with sequence similarity 160 member A1; Belongs to the UPF0518 family | SH3 domain-binding protein 4; May function in transferrin receptor internalization at the plasma membrane through a cargo-specific control of clathrin- mediated endocytosis. Alternatively, may act as a negative regulator of the amino acid-induced TOR signaling by inhibiting the formation of active Rag GTPase complexes. Preferentially binds inactive Rag GTPase complexes and prevents their interaction with the mTORC1 complex inhibiting its relocalization to lysosomes and its activation. Thereby, may indirectly regulate cell growth, proliferation and autophagy | 0.535 |
FAM160A1 | SIPA1L1 | ENSP00000413196 | ENSP00000450832 | Protein FAM160A1; Family with sequence similarity 160 member A1; Belongs to the UPF0518 family | Signal-induced proliferation-associated 1-like protein 1; Stimulates the GTPase activity of RAP2A. Promotes reorganization of the actin cytoskeleton and recruits DLG4 to F- actin. Contributes to the regulation of dendritic spine morphogenesis (By similarity); PDZ domain containing | 0.535 |
FAM160A1 | SMCO1 | ENSP00000413196 | ENSP00000380671 | Protein FAM160A1; Family with sequence similarity 160 member A1; Belongs to the UPF0518 family | Single-pass membrane protein with coiled-coil domains 1 | 0.669 |
HOOK1 | AKTIP | ENSP00000360252 | ENSP00000378152 | Protein Hook homolog 1; Required for spermatid differentiation. Probably involved in the positioning of the microtubules of the manchette and the flagellum in relation to the membrane skeleton (By similarity). Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex) | AKT-interacting protein; Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Regulates apoptosis by enhancing phosphorylation and activation of AKT1. Increases release of TNFSF6 via the AKT1/GSK3B/NFATC1 signaling cascade; Ubiquitin conjugating enzymes E2 | 0.987 |
HOOK1 | CCDC64B | ENSP00000360252 | ENSP00000459043 | Protein Hook homolog 1; Required for spermatid differentiation. Probably involved in the positioning of the microtubules of the manchette and the flagellum in relation to the membrane skeleton (By similarity). Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex) | BICD family-like cargo adapter 2; Coiled-coil domain containing 64B | 0.551 |
HOOK1 | FAM160A1 | ENSP00000360252 | ENSP00000413196 | Protein Hook homolog 1; Required for spermatid differentiation. Probably involved in the positioning of the microtubules of the manchette and the flagellum in relation to the membrane skeleton (By similarity). Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex) | Protein FAM160A1; Family with sequence similarity 160 member A1; Belongs to the UPF0518 family | 0.543 |
HOOK1 | HOOK3 | ENSP00000360252 | ENSP00000305699 | Protein Hook homolog 1; Required for spermatid differentiation. Probably involved in the positioning of the microtubules of the manchette and the flagellum in relation to the membrane skeleton (By similarity). Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex) | Protein Hook homolog 3; Probably serves as a target for the spiC protein from Salmonella typhimurium, which inactivates it, leading to a strong alteration in cellular trafficking (By similarity). Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). May regulate clearance of endocytosed receptors such as MSR1. Participates in defining the architecture and localization of the Golgi complex. Acts as an adapter protein linking the dynein motor c [...] | 0.982 |