FAM115C protein (human) - STRING database

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FAM115C

TRPM8 channel-associated factor 2; Isoform 2- Negatively regulates the plasma membrane cation channel TRPM8 activity. Involved in the recruitment of TRPM8 to the cell surface. Promotes prostate cancer cell migration stimulation in a TRPM8-dependent manner (845 aa)

Predicted Functional Partners:

CTAGE6

0.588

ENSG00000280178

0.559

EP400NL

0.559

ARHGEF38

0.550

FAM72A

0.544

TISP43

0.543

PYROXD2

0.537

GRHPR

0.487

PTPN20A

0.482

HARS

0.479

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARHGEF38	FAM115C	ENSP00000416125	ENSP00000412724	Rho guanine nucleotide exchange factor 38; May act as a guanine-nucleotide releasing factor; Classical BAR domain containing	TRPM8 channel-associated factor 2; Isoform 2- Negatively regulates the plasma membrane cation channel TRPM8 activity. Involved in the recruitment of TRPM8 to the cell surface. Promotes prostate cancer cell migration stimulation in a TRPM8-dependent manner	0.550
ARHGEF38	PYROXD2	ENSP00000416125	ENSP00000359607	Rho guanine nucleotide exchange factor 38; May act as a guanine-nucleotide releasing factor; Classical BAR domain containing	Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2; Probable oxidoreductase	0.580
CTAGE6	FAM115C	ENSP00000474388	ENSP00000412724	CTAGE family member 6	TRPM8 channel-associated factor 2; Isoform 2- Negatively regulates the plasma membrane cation channel TRPM8 activity. Involved in the recruitment of TRPM8 to the cell surface. Promotes prostate cancer cell migration stimulation in a TRPM8-dependent manner	0.588
CTAGE6	TISP43	ENSP00000474388	ENSP00000387081	CTAGE family member 6	Uncharacterized LOC150527	0.553
ENSG00000280178	FAM115C	ENSP00000485053	ENSP00000412724	PP13850	TRPM8 channel-associated factor 2; Isoform 2- Negatively regulates the plasma membrane cation channel TRPM8 activity. Involved in the recruitment of TRPM8 to the cell surface. Promotes prostate cancer cell migration stimulation in a TRPM8-dependent manner	0.559
EP400NL	FAM115C	ENSP00000374211	ENSP00000412724	EP400 N-terminal-like protein; EP400 N-terminal like	TRPM8 channel-associated factor 2; Isoform 2- Negatively regulates the plasma membrane cation channel TRPM8 activity. Involved in the recruitment of TRPM8 to the cell surface. Promotes prostate cancer cell migration stimulation in a TRPM8-dependent manner	0.559
FAM115C	ARHGEF38	ENSP00000412724	ENSP00000416125	TRPM8 channel-associated factor 2; Isoform 2- Negatively regulates the plasma membrane cation channel TRPM8 activity. Involved in the recruitment of TRPM8 to the cell surface. Promotes prostate cancer cell migration stimulation in a TRPM8-dependent manner	Rho guanine nucleotide exchange factor 38; May act as a guanine-nucleotide releasing factor; Classical BAR domain containing	0.550
FAM115C	CTAGE6	ENSP00000412724	ENSP00000474388	TRPM8 channel-associated factor 2; Isoform 2- Negatively regulates the plasma membrane cation channel TRPM8 activity. Involved in the recruitment of TRPM8 to the cell surface. Promotes prostate cancer cell migration stimulation in a TRPM8-dependent manner	CTAGE family member 6	0.588
FAM115C	ENSG00000280178	ENSP00000412724	ENSP00000485053	TRPM8 channel-associated factor 2; Isoform 2- Negatively regulates the plasma membrane cation channel TRPM8 activity. Involved in the recruitment of TRPM8 to the cell surface. Promotes prostate cancer cell migration stimulation in a TRPM8-dependent manner	PP13850	0.559
FAM115C	EP400NL	ENSP00000412724	ENSP00000374211	TRPM8 channel-associated factor 2; Isoform 2- Negatively regulates the plasma membrane cation channel TRPM8 activity. Involved in the recruitment of TRPM8 to the cell surface. Promotes prostate cancer cell migration stimulation in a TRPM8-dependent manner	EP400 N-terminal-like protein; EP400 N-terminal like	0.559
FAM115C	FAM72A	ENSP00000412724	ENSP00000356096	TRPM8 channel-associated factor 2; Isoform 2- Negatively regulates the plasma membrane cation channel TRPM8 activity. Involved in the recruitment of TRPM8 to the cell surface. Promotes prostate cancer cell migration stimulation in a TRPM8-dependent manner	Protein FAM72A; May play a role in the regulation of cellular reactive oxygen species metabolism. May participate in cell growth regulation; Belongs to the FAM72 family	0.544
FAM115C	GRHPR	ENSP00000412724	ENSP00000313432	TRPM8 channel-associated factor 2; Isoform 2- Negatively regulates the plasma membrane cation channel TRPM8 activity. Involved in the recruitment of TRPM8 to the cell surface. Promotes prostate cancer cell migration stimulation in a TRPM8-dependent manner	Glyoxylate reductase/hydroxypyruvate reductase; Enzyme with hydroxy-pyruvate reductase, glyoxylate reductase and D-glycerate dehydrogenase enzymatic activities. Reduces hydroxypyruvate to D-glycerate, glyoxylate to glycolate oxidizes D-glycerate to hydroxypyruvate	0.487
FAM115C	HARS	ENSP00000412724	ENSP00000425634	TRPM8 channel-associated factor 2; Isoform 2- Negatively regulates the plasma membrane cation channel TRPM8 activity. Involved in the recruitment of TRPM8 to the cell surface. Promotes prostate cancer cell migration stimulation in a TRPM8-dependent manner	Histidine--tRNA ligase, cytoplasmic; Cytoplasmic histidine--tRNA ligase (Probable). Plays a role in axon guidance; Aminoacyl tRNA synthetases, Class II	0.479
FAM115C	PTPN20A	ENSP00000412724	ENSP00000363459	TRPM8 channel-associated factor 2; Isoform 2- Negatively regulates the plasma membrane cation channel TRPM8 activity. Involved in the recruitment of TRPM8 to the cell surface. Promotes prostate cancer cell migration stimulation in a TRPM8-dependent manner	Tyrosine-protein phosphatase non-receptor type 20; Tyrosine-protein phosphatase targeted to sites of actin polymerization in response of varied extracellular stimuli. Has tyrosine phosphatase activity towards various tyrosyl phosphorylated substrates	0.482
FAM115C	PYROXD2	ENSP00000412724	ENSP00000359607	TRPM8 channel-associated factor 2; Isoform 2- Negatively regulates the plasma membrane cation channel TRPM8 activity. Involved in the recruitment of TRPM8 to the cell surface. Promotes prostate cancer cell migration stimulation in a TRPM8-dependent manner	Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2; Probable oxidoreductase	0.537
FAM115C	TISP43	ENSP00000412724	ENSP00000387081	TRPM8 channel-associated factor 2; Isoform 2- Negatively regulates the plasma membrane cation channel TRPM8 activity. Involved in the recruitment of TRPM8 to the cell surface. Promotes prostate cancer cell migration stimulation in a TRPM8-dependent manner	Uncharacterized LOC150527	0.543
FAM72A	FAM115C	ENSP00000356096	ENSP00000412724	Protein FAM72A; May play a role in the regulation of cellular reactive oxygen species metabolism. May participate in cell growth regulation; Belongs to the FAM72 family	TRPM8 channel-associated factor 2; Isoform 2- Negatively regulates the plasma membrane cation channel TRPM8 activity. Involved in the recruitment of TRPM8 to the cell surface. Promotes prostate cancer cell migration stimulation in a TRPM8-dependent manner	0.544
GRHPR	FAM115C	ENSP00000313432	ENSP00000412724	Glyoxylate reductase/hydroxypyruvate reductase; Enzyme with hydroxy-pyruvate reductase, glyoxylate reductase and D-glycerate dehydrogenase enzymatic activities. Reduces hydroxypyruvate to D-glycerate, glyoxylate to glycolate oxidizes D-glycerate to hydroxypyruvate	TRPM8 channel-associated factor 2; Isoform 2- Negatively regulates the plasma membrane cation channel TRPM8 activity. Involved in the recruitment of TRPM8 to the cell surface. Promotes prostate cancer cell migration stimulation in a TRPM8-dependent manner	0.487
HARS	FAM115C	ENSP00000425634	ENSP00000412724	Histidine--tRNA ligase, cytoplasmic; Cytoplasmic histidine--tRNA ligase (Probable). Plays a role in axon guidance; Aminoacyl tRNA synthetases, Class II	TRPM8 channel-associated factor 2; Isoform 2- Negatively regulates the plasma membrane cation channel TRPM8 activity. Involved in the recruitment of TRPM8 to the cell surface. Promotes prostate cancer cell migration stimulation in a TRPM8-dependent manner	0.479
PTPN20A	FAM115C	ENSP00000363459	ENSP00000412724	Tyrosine-protein phosphatase non-receptor type 20; Tyrosine-protein phosphatase targeted to sites of actin polymerization in response of varied extracellular stimuli. Has tyrosine phosphatase activity towards various tyrosyl phosphorylated substrates	TRPM8 channel-associated factor 2; Isoform 2- Negatively regulates the plasma membrane cation channel TRPM8 activity. Involved in the recruitment of TRPM8 to the cell surface. Promotes prostate cancer cell migration stimulation in a TRPM8-dependent manner	0.482

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